Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines

Lee, Do Kyung; Jang, Seok; Kim, Mi Jin; Kim, Jung Hyun; Chung, Myung Jun; Kim, Kyung Jae; Ha, Nam Joo

doi:10.1186/1471-2407-8-310

Cited by 110 publications

(62 citation statements)

References 41 publications

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“…Probiotics such as lactic acid bacteria help maintain health in numerous ways: (a) preventing overgrowth of pathogenic bacteria, (b) assisting in digestion, (c) protecting and enhancing immune function, (d) strengthening the intestinal mucosal barrier function and (e) neutralizing food mutagens produced in the colon (Fuller, 1989;Fernandes and Shahani, 1990;Lee et al, 2008). Bifidobacterias are generally considered beneficial for health and have been widely used, individually and/or in combination with lactobacilli, probiotic foods and products to increase the probiotic content in the human GI tract (Salminen et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

The combination of mixed lactic acid bacteria and dietary fiber lowers serum cholesterol levels and fecal harmful enzyme activities in rats

et al. 2011

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Probiotics such as lactic acid bacteria (LAB) and prebiotics such as fiber are generally considered beneficial for health. These affect the microflora composition and fermentation metabolites and consequently contribute to local and systemic effects in humans. The beneficial effects of probiotics can be improved when combined with prebiotics. Here we investigated the effects of a mixed LAB supplement combined with dietary fiber on the population of LAB in the gut, as well as on serum cholesterol levels, fecal water content and microbial harmful enzyme activities. For animal studies, 0.2 mL of mixed LAB (Bifidobacterium longum SPM1205, Lactobacillus acidophilus, and SAFELAC isolated from Pediococcus pentosaceus) supplement (10(7) ∼ 10(8) colony forming units per day) was orally administered to male Sprague-Dawley rats every day for 2 weeks along with a diet containing 5% or 10% cellulose. The mixed LAB supplement combined with dietary cellulose significantly (p < 0.05) reduced serum total cholesterol and LDL levels. This combination also significantly (p < 0.05) increased the population of LAB and the fecal water content and significantly (p < 0.05) reduced microbial harmful enzyme (β-glucosidase, β-glucuronidase and tryptophanase) activities. These effects of LAB were particularly improved by its combination with 5% cellulose compared to the control (a diet without cellulose), and the 5% cellulose combination was more effective than the 10% cellulose combination. In conclusion, the incorporation of a fibrous diet such as cellulose with lactic acid bacteria improved the population of LAB, and daily consumption of this combination could reduce the serum cholesterol levels and activities of harmful enzymes such as β-glucosidase, β-glucuronidase, tryptophanase, urease in rats.

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Section: Discussionmentioning

confidence: 99%

The combination of mixed lactic acid bacteria and dietary fiber lowers serum cholesterol levels and fecal harmful enzyme activities in rats

et al. 2011

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“…Thirabunyanon et al (2009) relatam que a aplicação de probióticos como um alimento funcional é importante para aumentar continuamente a saúde humana a cada ano. Embora os mecanismos precisos pelos quais BAL inibem cân-cer de cólon não sejam completamente conhecidos, vários mecanismos têm sido propostos: (a) o aumento da resposta imune do hospedeiro, (b) potenciais agentes cancerígenos degradantes, (c) alterações na microbiota intestinal que produzem carcinógenos, (d) a produção de compostos anti--tumorigênicos ou anti-mutagênicos no cólon, e (e) alteração das atividades metabólicas intestinal (Lee et al 2008). A utilização de modelo celular de câncer de cólon como as células caco-2 e HT-29 vêm sendo experimentadas para elucidar os mecanismos de ação das BAL frente à doença.…”

Section: Discussionunclassified

“…Até 75% dos casos estão associados com a alimentação, indicando que uma pessoa pode reduzir o seu risco simplesmente através de modificação na dieta (Chen et al 2012). De acordo com Lee et al (2008) apesar dos avanços recentes na compreensão dos processos biológicos resultantes do desenvolvimento do câncer, continua a existir uma necessidade de agentes novos e eficazes para controlar a doença.…”

Section: Introductionunclassified

Podem as bactérias ácido lácticas probióticas apresentarem efeito antitumoral em modelo animal de câncer de cólon? Uma revisão da literatura

et al. 2017

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ABSTRACT.-Calaça P.R.A., Bezerra R.P., Porto A. Colon cancer is one of the most common types of cancer in the world and the second leading cause of death related to the disease in developed countries. Up to 75% of cases are associated with eating, indicating that a person can reduce their risk simply through dietary modification. Studies in animals show that various strains of lactic acid bacteria protect against colon cancer in rodents although data in humans are limited and conflicting. The aim of this study was to investigate the efficacy of acid lactic bacteria in the treatment and reduction of colon cancer in animal models. Systematic searches were conducted in electronic databases reaching 1079 related articles, only six articles were elected according instead of to the eligibility criteria for analysis. All reviewed articles showed satisfactory results on the inhibition of colon cancer in rats and mice when using predominantly Lactobacillus strains. This study can answer hypothesis that acid lactic bacteria has antitumor effect against colon cancer.INDEX TERMS: Acid lactic bacteria, probiotics, colon câncer, antitumoral effect, animal model, literature review.

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“…Research studies also speculated that incorporation of probiotics in the diet can also have substantial impact on cell signaling system. L. reuteri may prevent carcinogenesis via downregulating NF-κB-dependent genes which regulate cell proliferation (Cox-2, cyclin D1) and survival (Bcl-2, Bcl-xL) [144]. In addition to that L. reuteri suppressed tumor necrosis factors (TNF)-induced NF-κB activation including NF-κB dependent reporter gene expression in a dose-and time-dependent manner to slow down cancer cell growth.…”

Section: Effect Of Probiotics On Modulation Of Immune Systemmentioning

confidence: 99%

Role of Probiotics in Pancreatic Cancer Prevention: The Prospects and Challenges

Singhal¹,

Mukherjee²

2016

ABB

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Pancreatic cancer is expressed as a disorder of chaos that leads to impairment in biochemical and metabolic physiology of pancreas. It is considered as the most intractable and fatal among all gastrointestinal (GI) cancers. The early occurrence of metastatic spread and the development of intrinsic and acquired resistance during drug treatment limit its prognosis at the right time. The universalized treatment involves surgical resection in which only a minority (<20%) of patients qualify due to advanced stage of disease at the time of diagnosis. Despite the rigorous technological developments in understanding the molecular mechanism of pancreatic cancer, no significant advances in efficacy of chemotherapeutic treatment have been arisen till date and still present challenges to overcome. That leads to the scientists to undergo exhaustive research to find an alternative treatment and increasing focus have been given on the studies of symbiotic relationships between microbiota and host which confers benefits to the host in many key aspects of life and form a synergistic harmony so called "super-organism". The perturbations in the regulatory circuits of the host that control homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and favors carcinogenesis in the pancreas. Research studies speculating convincing evidence that, among the gut microbiota, probiotics have demonstrated their potential role in the prevention of all stages of cancer development, but the critical question has been arisen that Can probiotics be used as preventive targets for pancreatic cancer? Thus, the efforts have been directed towards to summarize the prospective and challenging role of probiotics as preventive approach for pancreatic cancer. Though prospects of probiotics in prevention of pancreatic cancer are being great challenge among research community therefore, more rigorous and well-designed in vitro, animal and clinical studies are required for worthy manifestations.

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Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines

Cited by 110 publications

References 41 publications

The combination of mixed lactic acid bacteria and dietary fiber lowers serum cholesterol levels and fecal harmful enzyme activities in rats

The combination of mixed lactic acid bacteria and dietary fiber lowers serum cholesterol levels and fecal harmful enzyme activities in rats

Podem as bactérias ácido lácticas probióticas apresentarem efeito antitumoral em modelo animal de câncer de cólon? Uma revisão da literatura

Role of Probiotics in Pancreatic Cancer Prevention: The Prospects and Challenges

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