Anti-pruritic Effect of Ethanol Extracts from Platycodon grandiflorum and its fermented production in Scratching Behavior Mouse Models

Ha, Mi-Ae; Kim, Jin-Woo; Lee, Shin-Woo; Chun, Hyun-Sik; Cho, Young-Son; Shin, Yong-Wook

doi:10.6116/kjh.2014.29.6.165.

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Kim et al (2012) reported that fermented BF by Lactobacillus plantarum (LP), up regulate Th1 cytokines, IL-12, p40 and IFN-γ while the levels of the Th2 cytokines IL-4 and 5 were down-regulated. Ha et al (2014) reported that fermented with Saccharomyces cerevisae decreased the serum levels of Ig E, MDA and reducing Itching reactions in mouse. Oh et al (2010) demonstrate that BF Ext.…”

Section: Post Harvest Processingmentioning

confidence: 98%

Current Research Trends on Improvement of Balloon Flower Production and Processing

Lee¹,

Cho²,

Shin³

2014

J. Korean Soc. People Plants Environ.

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Balloon flower (BF, Platycodon grandiflorum (Jacq.) A.DC.) is a monotypic species of the bellflower family (Campanulaceae), which is native to Asia. In terms of popular culture of east asian country, BF has been in the limelight as flowers, medicine and food. Platycosides (saponins) from the roots of BF are reported to have a wide range of efficacy and characterized by a structure containing a triterpenoid aglycone and two sugar chains. Saponins from BF are of pharmaceutical significance, and their applications are increasing with evidence of their efficacy. As the cultivation area of BF is continually increased in Korea, research for preventing root rot incidence and nitogen fertilizer application on yield of saponin are reported and also storaging, steam heating and bio-transformational method are developed. There are several biological effects of compounds from BF. saponin from BF has cholesterol lowering effects, neuroprotective activity, cytotoxic effects against cancer cells, and polysaccharide has immuno-boosting effects and pheolic compounds from aerial part of BF has anti-oxidative effects. However, The purchase decision factor of consumers in market is cultivate year of BF and producing country are also important as contents of platycodins in BF. This paper reviews the origin of plants, harvest and post harvest processing methods that maximize the value in terms of efficacy of extracts and platicoside from BF.

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Section: Post Harvest Processingmentioning

confidence: 98%

Current Research Trends on Improvement of Balloon Flower Production and Processing

Lee¹,

Cho²,

Shin³

2014

J. Korean Soc. People Plants Environ.

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Nine Repetitive Steamed Platycodon grandiflorum Root Restores Th1/Th2 Cytokine Imbalance in an Ovalbumin-Induced Asthmatic Mouse Model

Kim¹,

Ha²,

Shin³

2016

J. Korean Soc. People Plants Environ.

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This study was performed to compare the effect of Platycodi Radix (PG) and Black Platycodi Radix (BPG; developed from fresh Platycodon grandiflorum root by steaming nine times at 80°C for 36 hr and drying nine times at 30°C for 24 hr , at which point it becomes black in color.) on anti-oxidant effect, anti-bacterial properties and ovalbumin (OVA)-induced allergic asthma mouse model by calculating serum cytokines and IgE. To induce the allergic asthma, in the control group and the sample treated group, mice of each group were sensitized intraperitoneally with OVA solution at the 1st, the 7th and the 14th day. Sensitization was performed by aerosol allergen challenges with 1% OVA solution intratracheally at the 21th, the 23th, the 25th and the 27th day. At the 29th day, the mice were killed and the levels of interferon-γ, interleukin-4, 5 and 10, total IgE and OVA-specific IgE were measured. IFN-γ was not different among the PG, BPG, and control groups. IL-4, IL-5, IL-13, total IgE, and OVA-specific IgE were significantly in the BPG group compared with the control group. Considering the above experimental results, this study showed that nine times-repitative steaming process on the roots of Platycodon grandiflorum could enhance reduction of the allergic reaction by reducing level of OVA specific IgE and immune cell infiltration and restoring Th1/Th2 cytokine imbalance.

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Anti-pruritic Effect of Ethanol Extracts from Platycodon grandiflorum and its fermented production in Scratching Behavior Mouse Models

Cited by 2 publications

References 43 publications

Current Research Trends on Improvement of Balloon Flower Production and Processing

Current Research Trends on Improvement of Balloon Flower Production and Processing

Nine Repetitive Steamed Platycodon grandiflorum Root Restores Th1/Th2 Cytokine Imbalance in an Ovalbumin-Induced Asthmatic Mouse Model

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