Anti-pyretic, anti-infl ammatory, and analgesic effects of leaf extract of drumstick tree

Abstract

Objectives:The aim was to investigate the antipyretic, anti-infl ammatory and analgesic activity of ethanolic leaf extract of Moringa oleifera, commonly known as drumstick tree. Materials and Methods: The study is a randomized controlled experimental study. The experiments were carried out dividing the animals in six groups, each containing six animals. Ethanolic extract of Moringa M. oleifera (EMO was administered at 50, 100, 200, 400 mg/kg doses orally to the respective four groups. Control was normal saline (orally at 2 ml/kg body weight). Antipyretic activity was done in albino rats using the Brewer's yeast induced pyrexia model, standard used was paracetamol (100 mg/kg). Anti-infl ammatory action was screened using carrageenan induced paw edema model in albino rats. Analgesic actions was evaluated using acetic acid induced writhing test and Eddy's hot plate test for the peripheral and central analgesic actions respectively using albino mice. Results: The ethanolic leaf extract of M. oleifera showed signifi cant (P < 0.05) antipyretic and anti-infl ammatory activities at 100, 200, 400 mg/kg. The percentage inhibition of paw edema at 3 rd h was 64.77% for aspirin and EMO 400 mg/kg showed 56.81% comparing with the control. Signifi cant (P < 0.01) analgesic activity was exhibited by ethanolic leaf extract of M. oleifera at 100, 200, 400 mg/kg in both the acetic acid induced writhing test and the Eddy's hot plate test in comparison with control. Dose-dependent increase in the percentage inhibition of writhes was noted with EMO 100, 200, 400 mg/kg showing 26%, 51% and 81%, respectively. Conclusion: Thus, our study concludes that EMO leaves has antipyretic, anti-infl ammatory, and both central and peripheral analgesic actions.

Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition

“…This activity was indeed demonstrated using the acetic acid induced convulsion test and the Eddy hot plate test for peripheral and central analgesic actions respectively using albino mice. The ethanolic leaf extract of M. oleifera showed significant analgesic activity at 100, 200, 400 mg / kg in both tests compared to the control group (Bhattacharya et al, 2014).…”

Scientific Basis of Ethno-pharmacological Claims of Moringa Oleifera Lam.

“…19 In the Sultanate of Oman, the seeds of this plant are the most widely used to treat diabetes. 32,33 Convulsions or infantile paralysis are treated using pod oil in the northern region of Oman, where it is utilised to cure the condition. 34 Additionally, it is widely used in the Indian subcontinent to treat diabetes-related symptoms such as hyperlipidemia and hyperglycemia, among other things.…”

Chemical Analysis, Antioxidant, Anti-Inflammatory and Antinociceptive Effects of Acetone Extract of Algerian Solenostemma Argel (Delile) Hayne Leaves

“…AESA at the highest dose (400 mg/kg) showed a nociceptive effect comparable to that of indomethacin (10 mg/kg), which served as a standard in this case. The intraperitoneal injection of acetic acid causes the release of prostanoids, particularly PGE2, PGF2, bradykinin, serotonin, lipoxygenase in the in peritoneal fluids [10]. Prostaglandins activate and sensitize peripheral chemo sensitive nociceptive receptors, leading to the induction of abdominal constrictions that are accompanied by extension of the forelimbs and elongation of the body [52].…”

“…Steroidal and non-steroidal anti-inflammatory drugs are widely prescribed because of their effectiveness in the management of pain and inflammation but their prolonged administration is known to be associated with various side effects. Traditional medicine, which is based on the natural plants use, has already been declared by WHO as promotive, preventive, curative and rehabilitative [10]. In this context, the use of natural resources, and more particularly of medicinal plants, becomes a promising research voice to explore and discover effective drugs with fewer side effects.…”