Anti-quorum sensing and antibiofilm potential of 1,8-cineole derived from Musa paradisiaca against Pseudomonas aeruginosa strain PAO1

Vijayakumar, K. R.; Thirunanasambandham, Ramanathan; Gunasekaran, Thangaraj

doi:10.1007/s11274-021-03029-y

Cited by 18 publications

(14 citation statements)

References 42 publications

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“…In agreement with previous reports on several chemical constituents of the same EOs [ 16 , 17 ], it could be speculated that eucalyptol and linalool could be listed as common chemical compounds that reduce biofilms in both S. aureus and P. aeruginosa reference and clinical isolates strains. Indeed, Karuppia and coworkers, and Kifer and coworkers in two independent reports demonstrate that eucalyptol plays an antibiofilm role in S. aureus and P. aeruginosa [ 49 , 50 ], while linalool was independently pointed to by Lahiri and Kerekes as an important regulator of S. aureus and P. aeruginosa biofilm formation [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

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Essential Oils Biofilm Modulation Activity and Machine Learning Analysis on Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

et al. 2022

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The opportunistic pathogen Pseudomonas aeruginosa is often involved in airway infections of cystic fibrosis (CF) patients. It persists in the hostile CF lung environment, inducing chronic infections due to the production of several virulence factors. In this regard, the ability to form a biofilm plays a pivotal role in CF airway colonization by P. aeruginosa. Bacterial virulence mitigation and bacterial cell adhesion hampering and/or biofilm reduced formation could represent a major target for the development of new therapeutic treatments for infection control. Essential oils (EOs) are being considered as a potential alternative in clinical settings for the prevention, treatment, and control of infections sustained by microbial biofilms. EOs are complex mixtures of different classes of organic compounds, usually used for the treatment of upper respiratory tract infections in traditional medicine. Recently, a wide series of EOs were investigated for their ability to modulate biofilm production by different pathogens comprising S. aureus, S. epidermidis, and P. aeruginosa strains. Machine learning (ML) algorithms were applied to develop classification models in order to suggest a possible antibiofilm action for each chemical component of the studied EOs. In the present study, we assessed the biofilm growth modulation exerted by 61 commercial EOs on a selected number of P. aeruginosa strains isolated from CF patients. Furthermore, ML has been used to shed light on the EO chemical components likely responsible for the positive or negative modulation of bacterial biofilm formation.

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Section: Discussionmentioning

confidence: 99%

“…In spite of reports supporting the above hypothesis on biofilm inhibition [ 12 , 49 , 50 , 51 ], further investigations on ad hoc selected EOs or their isolated chemical compounds are required to confirm the role of single molecules and their synergistic or anti-synergistic effects.…”

Section: Discussionmentioning

confidence: 99%

Essential Oils Biofilm Modulation Activity and Machine Learning Analysis on Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

et al. 2022

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“…The monoterpene 1,8-cineole, the major component of EOCC, inhibits various microbial strains [ 35 , 36 , 37 ] including MRSA strains [ 38 ]. It shows antibiotic activity both toward the bacteria, such as Escherichia coli , Klebsiella pneumoniae and Pseudomonas aeruginosa , and the biofilms of pathogenic yeasts, such as Candida albicans [ 39 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic and Antibiofilm Effects of the Essential Oil from Croton conduplicatus (Euphorbiaceae) against Methicillin-Resistant Staphylococcus aureus

et al. 2022

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Bacterial resistance refers to the ability of bacteria to resist the action of some antibiotics due to the development of adaptation and resistance mechanisms. It is a serious public health problem, especially for diseases caused by opportunistic bacteria. In this context, the search for new drugs, used alone or in combination, appears as an alternative for the treatment of microbial infections, and natural products, such as essential oils, are important in this process due to their structural diversity, which increases the probability for antimicrobial action. The objective of this study was to extract and identify the chemical components of the essential oil from Croton conduplicatus (EOCC), to evaluate the antimicrobial activity, to investigate the effect of the interaction between the EOCC and different antibiotics and to evaluate its antibiofilm potential. The EOCC was obtained by hydrodistillation. Based on chemical characterisation, 70 compounds were identified, with 1.8 cineole (13.15%), p-cymene (10.68%), caryophyllene (9.73%) and spathulenol (6.36%) being the major constituents. The minimum inhibitory concentration (MIC) values of EOCC were 256 and 512 µg mL−1 for methicillin-sensitive and -resistant Staphylococcus aureus strains (MSSA and MRSA), respectively. The combinations of EOCC with the antibiotics oxacillin and ampicillin were synergistic (OXA/EOCC and AMP/EOCC combined decreased the OXA MIC and AMP MIC to 0.5 and 0.25 for MSSA, respectively, and OXA/EOCC and AMP/EOCC combined decreased the OXA MIC and the AMP MIC to 1 and 0.5 for MRSA, respectively) and could modify the resistance profile of MSSA and MRSA strains. The results indicated that EOCC was also able to partially inhibit biofilm formation. Our study presents important information about the chemical composition of EOCC and its antimicrobial potential and provides a reference to determine the mechanisms of action of EOCC and its use in pharmaceutical formulations.

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“…Nevertheless, by means of both methods, R-EO, T-EO and TT-EO in their liquid forms can be pointed out as the most potent against the pseudomonal biofilm, which is in line with the results of other research teams. It was reported that above 90% reduction of P. aeruginosa biofilm was obtained after the incubation with T-EO and that 1,8-cineole, the main component of R-EO, greatly affected P. aeruginosa biofilm formation and disrupted the mature biofilm [18,[22][23][24]. The volatile fractions of R-EO and TT-EO also displayed high effectiveness against P. aeruginosa biofilm, which may result from their multiple mechanisms of anti-biofilm activity.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity of Liquid and Volatile Phase of Essential Oils against Planktonic and Biofilm-Forming Cells of Pseudomonas aeruginosa

et al. 2022

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Pseudomonas aeruginosa is an opportunistic pathogen causing life-threatening, hard-to-heal infections associated with the presence of a biofilm. Essential oils (EOs) are promising agents to combat pseudomonal infections because of the alleged antimicrobial activity of their volatile fractions and liquid forms. Therefore, the purpose of this paper was to evaluate the antibacterial efficacy of both volatile and liquid phases of seven EOs (thyme, tea tree, basil, rosemary, eucalyptus, menthol mint, lavender) against P. aeruginosa biofilm and planktonic cells with the use of a broad spectrum of analytical in vitro methods. According to the study results, the antibacterial activity of EOs in their liquid forms varied from that of the volatile fractions. Overall, liquid and volatile forms of rosemary EO and tea tree EO displayed significant antibiofilm effectiveness. The outcomes indicate that these particular EOs possess the potential to be used in the therapy of P. aeruginosa infections.

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Anti-quorum sensing and antibiofilm potential of 1,8-cineole derived from Musa paradisiaca against Pseudomonas aeruginosa strain PAO1

Cited by 18 publications

References 42 publications

Essential Oils Biofilm Modulation Activity and Machine Learning Analysis on Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

Essential Oils Biofilm Modulation Activity and Machine Learning Analysis on Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

Synergistic and Antibiofilm Effects of the Essential Oil from Croton conduplicatus (Euphorbiaceae) against Methicillin-Resistant Staphylococcus aureus

Chemical Composition and Antibacterial Activity of Liquid and Volatile Phase of Essential Oils against Planktonic and Biofilm-Forming Cells of Pseudomonas aeruginosa

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