Anti-Retinal Autoimmunity and Circulating Immune Complexes in Patients With Retinal Vasculitis

Dumonde, D. C.; Graham, Elizabeth; Kasp-Grochowska, E.; Sanders, Michael; Faure, Jean‐Pierre; Kozak, Y. de; Tuyen, VV

doi:10.1016/s0140-6736(82)92679-4

Cited by 82 publications

(30 citation statements)

References 11 publications

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“…Fundus fluorescein angiography (FFA) was performed at the beginning of CSA therapy, then in the first, third and sixth months, followed by six month intervals and whenever necessary. The severity of inflammatory activity was graded according to the criteria which were described earlier by Dumonde et al (1982). Patients were followed-up by weekly intervals in the first month, and monthly thereafter.…”

Section: Methodsmentioning

confidence: 99%

Cyclosporin‐A therapy in severe uveitis of Behçet's disease

Süllü

Öge

Erkan

et al. 1998

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Cyclosporine-A (CSA) combined with corticosteroid therapy was administered to 12 patients with severe Behçet's uveitis who were resistant to colchicine or cytotoxic therapy. Methods: Previous colchicine or cytotoxic therapies were tapered off one month before CSA therapy. All patients were started on an initial oral dose of 5 mg/ kg/day of CSA. After the first three months, the CSA dose was reduced to a maintenance dose according to the intraocular inflammatory response. Results: The average follow-up period was 20 (12-36) months. Visual acuity remained the same in 12 (%54.5) and improved in 8 (%36.4) eyes. There was a decrease in the frequency (p∞0.01) and severity (p∞0.01) of ocular attacks and in the maintenance steroid dose (p∞0.01) when compared with conventional therapy. The frequent side effects were paraesthesia-hyperesthesia, fatigue, nausea, hirsutism and dose-related nephrotoxicity in one patient. Conclusion:The results of the study suggest that low dose CSA combined with low dose corticosteroid may be an effective therapeutic alternative in the treatment of severe refractory Behçet's uveitis.

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Section: Methodsmentioning

confidence: 99%

Cyclosporin‐A therapy in severe uveitis of Behçet's disease

Süllü

Öge

Erkan

et al. 1998

Acta Ophthalmologica Scandinavica

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“…1 However, in spite of intensive investigation, specific <etiological agent(s) have rarely been demonstrated, and associa tions with other systemic diseases have been shown in only 50% of cases.2-4 A large prop ortion of these cases present evidence of an immunological disturbance indicating that immune mechanisms are involved in initiat ing and/or establishing the chronicity of the disease and its tendency to recur. [5][6][7][8][9] Experi mental autoimmune uveitis (EAU) induced by retinal antigens, particularly S-antigen is a useful animal model of chronic intraocular inflammation. Besides uveitis, S-antigen in duces an inflammatory reaction in the pineal gland thereby demonstrating another link between the pineal gland and the eye.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulation of Experimental Autoimmune Uveitis using a rat anti retinal S-antigen specific monoclonal antibody: Evidence for a species difference

Dua

Liversidge²,

Forrester³

1989

Eye

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SummaryExperimental Autoimmune Uveitis (EAU) induced by retinal antigens, particularly S-antigen, forms a useful model of human chronic intraocular inflammation particularly endogenous post erior uveitis. It provides a means of assessing the efficacy of various agents used in the control of such inflammation. We induced an autoimmune uveitis and its associated pinealitis in Dun kin-Hartley guinea pigs and Lewis rats by inoculating them with bovine retinal S-antigen. In rats, induction of EAU but not of Experimental Autoimmune Pinealitis (EAP) could be pre vented by the administration of S-antigen specific rat monoclonal antibody simultaneously with the S-antigen. Inhibition of EAU was accompanied by significantly raised levels of anti-S antibodies during the first two weeks post-immunisation. In contrast, the same monoclonal antibody failed to inhibit both EAU and EAP in guinea pigs. Immunocytochemical staining of rat tissues for lymphocyte subsets, monocytes and macrophages showed that eyes of monoc lonal antibody treated animals contained no immunocompetent inflammatory cells unless they also had clinical signs of inflammation. In contrast, the inflammatory exudate in the pineal glands of both treated and untreated animals contained equal numbers of infiltrating lympho cytes and monocytes in the same relative proportions. These results indicate that the inhibitory effect of the monoclonal antibody S2.4.CS is directed towards the effector arm of the immune mediated cytotoxic response. A possible mechanism by which the antibody may be preferen tially inhibiting the inflammatory response in the eyes but not in the pineal glands of rats, is suggested.Chronic intraocular inflammation is an important cause of ocular morbidity and vis ual loss particularly among young adults. Several exogenous and endogenous factors have been identified in the

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“…12 These findings differentiate patients with ocular lymphoma from patients with uveitis due to other causes such as sar coidosis where colour vision and visual fields are usually preserved and macular oedema is the main reason for loss of central vision. 13 The clinical features of reduced colour vision and constricted visual fields suggest early involvement of the optic nerve and ret ina as the cause of visual loss. These obser vations are supported by histopathological evidence: tumour cells are condensed between the pigment epithelium and Bruch's membrane and infiltrating the optic nerve head to the level of the lamina cribrosa.1.I4.15.1 6 ,17 Perivascular cuffing is fre quently seen in the retinal blood vessels 6 but tumour cells rarely infiltrate the vessel walls.…”

Section: Discussionmentioning

confidence: 99%

Intraocular involvement of T and B cell lymphomas

Graham

1987

Eye

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Anti-Retinal Autoimmunity and Circulating Immune Complexes in Patients With Retinal Vasculitis

Cited by 82 publications

References 11 publications

Cyclosporin‐A therapy in severe uveitis of Behçet's disease

Cyclosporin‐A therapy in severe uveitis of Behçet's disease

Immunomodulation of Experimental Autoimmune Uveitis using a rat anti retinal S-antigen specific monoclonal antibody: Evidence for a species difference

Intraocular involvement of T and B cell lymphomas

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