Anti-rheumatic, and analgesic effects by the parent tuberous roots of Aconitum jaluense in adjuvant induced arthritis rats

Lee, Ji Suk; Bae, YoungChul; Kim, Nam Jae; Lim, Sabina; Kim, Youngmi; Kim, Jinwoong; Chin, Young‐Won

doi:10.1016/j.jep.2021.114518

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…These alterations were observed in the present study, as well as in previous research using the same inflammatory agent [10,39,40]. The irritant impact of CFA is what causes the initial increase in edema, a characteristic observed in all animals, along with the thickening of the soft tissue [32].…”

Section: Size Of Edema (Mm)supporting

confidence: 89%

“…Therefore, using the same sample, we evaluated the treatment effect of PgEO on a model of chronic inflammation induced by Complete Freund's Adjuvant (CFA). The mouse model with CFA-induced arthritis is a well-known example of a painful arthritic joint that results in inflammationrelated behaviors, such as increased edema, pro-inflammatory cytokines, reduced weight, and decreased use of the arthritic joint [32,33]. Joint edema is a common and significant manifestation in the context of arthritis, a chronic inflammatory condition that affects millions of people worldwide.…”

Section: Resultsmentioning

confidence: 99%

“…inflammation induced by Complete Freund's Adjuvant (CFA). The mouse model with CFA-induced arthritis is a well-known example of a painful arthritic joint that results in inflammation-related behaviors, such as increased edema, pro-inflammatory cytokines, reduced weight, and decreased use of the arthritic joint [32,33].…”

Section: Resultsmentioning

confidence: 99%

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Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Costa,

Alves,

Fonseca

et al. 2024

DDC

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Rheumatoid arthritis (RA) is a chronic and debilitating condition that affects a significant number of individuals worldwide. Unfortunately, the currently available therapeutic approaches often yield unsatisfactory results and may be accompanied by harmful side effects. A medicinal plant called Psidium glaziovianum Kiaersk has potential benefits in the treatment of this condition due to its anti-inflammatory and analgesic properties. In this study, our objective was to investigate the potential therapeutic effects of P. glaziovianum essential oil (PgEO) in alleviating arthritis symptoms in mice induced by Complete Freund’s Adjuvant (CFA). The effect of P. glaziovianum essential oil was evaluated in mice with Complete Freund’s Adjuvant (CFA)-induced arthritis. Edema sizes, macroscopic and radiographic images, cytokine levels, and oxidative stress were evaluated. Administration of PgEO at dosages of 50 and 100 mg/kg effectively prevented CFA-induced osteoarticular changes in arthritic mice, resulting in a significant reduction in joint damage. Additionally, the PgEO treatment exhibited the ability to minimize edema, a common symptom associated with arthritis. Furthermore, PgEO can modulate the levels of pro-inflammatory cytokines and oxidative stress, both of which play crucial roles in the progression of the disease. In conclusion, our study suggests that PgEO holds great potential as a natural therapeutic agent for rheumatoid arthritis.

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Section: Size Of Edema (Mm)supporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

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Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Costa,

Alves,

Fonseca

et al. 2024

DDC

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“…As the primary botanical drugs of FFXHL, AC and AK contain aconitine, benzoylaconine, and aconine, exhibiting anti-inflammatory ( Lee et al, 2022 ; Yu et al, 2020 ), analgesic ( Wang et al, 2012 ), and immunomodulatory effects ( Deng et al, 2018 ). Benzoylaconine, found in AC, has been shown to suppress IL-1β-induced expression of IL-6 and IL-8 by inhibiting the activation of MAPKs, Akt, and NF-κB pathways, suggesting its potential as a therapeutic agent for synovial inflammation in RA ( Yu et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-rheumatoid arthritis effects of traditional Chinese medicine Fufang Xiaohuoluo pill on collagen-induced arthritis rats and MH7A cells

Yin,

Huang,

Zhang

et al. 2024

Front. Pharmacol.

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BackgroundFufang Xiaohuoluo pill (FFXHL) is a commonly used prescription in clinical practice for treating rheumatoid arthritis in China, yet its specific mechanism remains unclear. This study aims to elucidate the pharmacological mechanisms of FFXHL using both in vivo and in vitro experiments.MethodsThe collagen-induced arthritis (CIA) rat model was established to evaluate FFXHL’s therapeutic impact. Parameters that include paw swelling, arthritis scores, and inflammatory markers were examined to assess the anti-inflammatory and analgesic effects of FFXHL. Human fibroblast-like synoviocytes (MH7A cells) is activated by tumour necrosis factor-alpha (TNF-α) were used to explore the anti-inflammatory mechanism on FFXHL.ResultsOur findings indicate that FFXHL effectively reduced paw swelling, joint pain, arthritis scores, and synovial pannus hyperplasia. It also lowered serum levels of TNF-α, interleukin-1β (IL1β), and interleukin-6 (IL-6). Immunohistochemical analysis revealed decreased expression of nuclear factor-kappa B (NF-κB) p65 in FFXHL-treated CIA rat joints. In vitro experiments demonstrated FFXHL’s ability to decrease protein secretion of IL-1β and IL-6, suppress mRNA expression of matrix metalloproteinases (MMP) −3, −9, and −13, reduce reactive oxygen species (ROS) levels, and inhibit NF-κB p65 translocation in TNF-α stimulated MH7A cells. FFXHL also suppressed protein levels of extracellular signal-regulated kinase (ERK), c-Jun Nterminal kinase (JNK), p38 MAP kinase (p38), protein kinase B (Akt), p65, inhibitor of kappa B kinase α/β (IKKα/β), Toll-like receptor 4 (TLR4), and myeloid differentiation primary response 88 (MyD88) induced by TNF-α in MH7A cells.ConclusionThe findings imply that FFXHL exhibits significant anti-inflammatory and antiarthritic effects in both CIA rat models and TNF-α-induced MH7A cells. The potential mechanism involves the inactivation of TLR4/MyD88, mitogen-activated protein kinases (MAPKs), NF-κB, and Akt pathways by FFXHL.

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“…Aconite and its components have been found to conduct bidirectional regulation of immune status in diseases, including chronic glomerulonephritis, rheumatic arthritis, osteoarthritis, and allergic rhinitis [35][36][37]. Tis efect can be explained by both immune stimulation and antiinfammation efects.…”

Section: Discussionmentioning

confidence: 99%

The Immunoregulatory Effect of Aconite Treatment on H22 Tumor‐Bearing Mice via Modulating Adaptive Immunity and Natural Killer‐Related Immunity

Wang

Jia³

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and, in its advanced stages, has a 5-year survival rate of only 3% to 5%. Despite novel mechanisms and treatments being uncovered over the past few years, effective strategies for HCC are currently limited. Previous studies have proven that aconite can suppress tumor growth and progression and prevent the recurrence and metastasis of multiple cancers, but the underlying molecular mechanisms are largely unknown. In this study, different doses of aconite were applied to mice bearing subcutaneous HCC tumors. It was found that aconite had a therapeutic effect on H22 tumor-bearing mice in a dose-dependent manner by reducing tumor volumes and prolonging survival times, which could be attributed to the immunoregulatory effect of aconite. Furthermore, results showed that high-dose administration of aconite could enhance adaptive immunity and natural killer (NK) cell-mediated immunity by regulating the secretion of interferon-γ, upregulating T cells and NK cells, and modulating the expression of the NK cytotoxicity biomarker CD107a and the inhibitory receptor TIGIT. This study revealed a novel mechanism through which aconite exerts antitumor effects, not merely through apoptosis induction pathways, providing more sound evidence that aconite has the potential to be developed into an effective anti-HCC agent.

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Anti-rheumatic, and analgesic effects by the parent tuberous roots of Aconitum jaluense in adjuvant induced arthritis rats

Cited by 6 publications

References 62 publications

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Anti-rheumatoid arthritis effects of traditional Chinese medicine Fufang Xiaohuoluo pill on collagen-induced arthritis rats and MH7A cells

The Immunoregulatory Effect of Aconite Treatment on H22 Tumor‐Bearing Mice via Modulating Adaptive Immunity and Natural Killer‐Related Immunity

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