Anti-SARS-CoV-2 Seropositivity Among Children With Newly Diagnosed Type 1 Diabetes Mellitus: A Case-Control Study

Herczeg, Vivien; Luczay, Andrea; Ténai, Nikolett; Czine, Gréta; Tóth-Heyn, Péter

doi:10.1007/s13312-022-2626-y

Cited by 6 publications

(9 citation statements)

References 10 publications

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“…The literature search yielded seventeen studies, of which fifteen were cohort studies and two were case–control studies [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. There were six studies that estimated the incidence of diabetes mellitus type 2 after a SARS-CoV-2 infection, four studies that estimated the incidence of diabetes mellitus type 1, six studies that assessed both types, and one study that did not specify the assessed type ( Table 1 ) [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Diabetes Mellitus after SARS-CoV-2 Infection: An Epidemiological Review

Ilić

2023

Life

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Diabetes mellitus (DM) is among the major global public health issues. According to recent projections, a continued rise in DM prevalence is expected in the following decades. The research has shown that DM is associated with poorer outcomes of coronavirus disease 2019 (COVID-19). However, there is growing evidence suggesting that COVID-19 is associated with new-onset DM type 1 and type 2. This review aims to summarize the current knowledge about the new onset of DM following COVID-19. All identified studies were longitudinal, and they have predominantly shown a significantly increased risk for new-onset DM (both type 1 and type 2) following a SARS-CoV-2 infection. Increased risk of poorer COVID-19 outcomes (mechanical ventilation, death) was noted in persons with new-onset DM following SARS-CoV-2 infection. Studies investigating risk factors for new-onset DM in COVID-19 patients showed that severe disease, age, ethnicity, ventilation, and smoking habits were associated with DM occurrence. The information summarized in this review presents a valuable source of evidence for healthcare policymakers and healthcare workers in the effort of planning prevention measures for new-onset DM after SARS-CoV-2 infection and the timely identification and appropriate treatment of patients with COVID-19 who could be at greater risk for new-onset DM.

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Section: Resultsmentioning

confidence: 99%

Diabetes Mellitus after SARS-CoV-2 Infection: An Epidemiological Review

Ilić

2023

Life

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“…Among the 25 eligible studies, there were 15 (60%) multicenter or nationwide studies ( 7 , 10 , 11 , 13 , 19 , 20 , 24 , 26 , 28 , 30 , 31 , 33 - 36 ). New-onset type 1 diabetes incidence was reported in 13 manuscripts (52%) ( 8 , 10 , 13 , 20 , 21 , 23 - 27 , 32 , 35 , 36 ) from countries other than Hungary ( 37 ) and Turkey ( 38 ), which are not included in Table 1 . Eighteen studies reported DKA incidence or severity ( 7 - 13 , 21 - 27 , 29 , 30 , 32 , 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…COVID-19 and T1D Incidence. The incidence of NT1D in children was increased in England ( 35 ), Germany ( 20 ), Hungary ( 37 ), Romania ( 25 ), Turkey ( 27 ), and USA ( 32 , 36 ) but not in Australia ( 8 ), Israel ( 21 ), Poland ( 13 , 23 , 24 ), Saudi Arabia ( 26 ), and Turkey ( 38 ) during the COVID-19 pandemic. Furthermore, there was no significant increase in new-onset autoantibody-negative T1D in children, adolescents, and young adults in Germany ( 10 ); nevertheless, NT1D and autoantibody positivity were higher in Turkey ( 27 ) during the pandemic.…”

Section: Resultsmentioning

confidence: 99%

Type 1 Diabetes and COVID-19: A Literature Review and Possible Management

Kashfi,

Anbardar,

Asadipooya

et al. 2023

Int J Endocrinol Metab

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Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection normally damages the respiratory system but might likewise impair endocrine organs’ function. Thyroid dysfunction and hyperglycemia are common endocrine complications of SARS-CoV-2 infection. The onset of type 1 diabetes (T1D) and associated complications, including diabetic ketoacidosis (DKA), hospitalization, and death, are thought to have increased during the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to review the available data about the incidence rate of T1D and accompanying complications since the beginning of the COVID-19 pandemic. Evidence Acquisition: A literature review was conducted using the electronic databases PubMed and Google Scholar. The keywords “T1D, T1DM, Type 1 DM or Type 1 Diabetes”, “Coronavirus, SARS-CoV-2 or COVID-19” were used to search these databases. Titles and abstracts were screened for selection, and then relevant studies were reviewed in full text. Results: A total of 25 manuscripts out of 304 identified studies were selected. There were 15 (60%) multicenter or nationwide studies. The data about the incidence rate of T1D, hospitalization, and death are not consistent across countries; however, DKA incidence and severity seem to be higher during the COVID-19 pandemic. The present study’s data collection demonstrated that COVID-19 might or might not increase the incidence of T1D. Nevertheless, it is associated with the higher incidence and severity of DKA in T1D patients. This finding might indicate that antivirals are not fully protective against the endocrine complications of SARS-CoV-2 infection, which promotes the application of an alternative approach. Conclusions: Combining medications that reduce SARS-CoV-2 entry into the cells and modulate the immune response to infection is an alternative practical approach to treating COVID-19.

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“…Several studies report a clear increase in the incidence of T1D since the beginning of the worldwide spread of the SARS-CoV-2 virus [ 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. According to a meta-analysis by Rahmati et al [ 114 ], the global new-onset of childhood T1D rate in 2020 was 32.39 per 100,000 children, clearly higher in comparison with 2019 (19.73 per 100,000 children) [ 114 ].…”

Section: Diabetesmentioning

confidence: 99%

“…Similar results were reported in a study conducted on subjects aged <16 years in Belgium, in whom SARS-CoV-2 serology was tested within the first month from diabetes onset [ 117 ]. Conversely, other centers have reported a previous coronavirus infection or precise exposure to the virus in most of their patients newly diagnosed with T1DM [ 112 , 113 ].…”

Section: Diabetesmentioning

confidence: 99%

Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review

Calcaterra

Tagi

Santis

et al. 2023

JCM

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Since the advent of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increased incidence of several endocrinological anomalies in acute-phase and/or long-term complications has been described. The aim of this review is to provide a broad overview of the available literature regarding changes in the worldwide epidemiology of endocrinological involvement in children since December 2019 and to report the evidence supporting its association with coronavirus disease 2019 (COVID-19). Although little is known regarding the involvement of endocrine organs during COVID-19 in children, the current evidence in adults and epidemiological studies on the pediatric population suggest the presence of a causal association between the virus and endocrinopathies. Untreated transient thyroid dysfunction, sick euthyroid syndrome, nonthyroidal illness syndrome, and hypothalamic–pituitary–adrenal (HPA) axis and central precocious puberty have been observed in children in acute infection and/or during multisystem inflammatory syndrome development. Furthermore, a higher frequency of ketoacidosis at onset in children with a new diagnosis of type 1 diabetes is reported in the literature. Although the direct association between COVID-19 and endocrinological involvement has not been confirmed yet, data on the development of different endocrinopathies in children, both during acute infection and as a result of its long-term complications, have been reported. This information is of primary importance to guide the management of patients with previous or current COVID-19.

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Anti-SARS-CoV-2 Seropositivity Among Children With Newly Diagnosed Type 1 Diabetes Mellitus: A Case-Control Study

Cited by 6 publications

References 10 publications

Diabetes Mellitus after SARS-CoV-2 Infection: An Epidemiological Review

Diabetes Mellitus after SARS-CoV-2 Infection: An Epidemiological Review

Type 1 Diabetes and COVID-19: A Literature Review and Possible Management

Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review

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