2022
DOI: 10.1016/j.bioactmat.2022.03.007
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Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells

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Cited by 12 publications
(10 citation statements)
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“…Macrophages can be divided into activated macrophages (M1 phenotype) and alternatively activated macrophages (M2 phenotype). [ 45 ] The transformation of pro‐inflammatory M1 macrophages into reparative M2 macrophages is a key step in promoting wound healing, leading to the regression of inflammation and the promotion of tissue repair. CD86, the main synergistic factor that induces T lymphocyte proliferation and interleukin‐2 (IL‐2) production, is a characteristic marker of M1 macrophages.…”
Section: Resultsmentioning
confidence: 99%
“…Macrophages can be divided into activated macrophages (M1 phenotype) and alternatively activated macrophages (M2 phenotype). [ 45 ] The transformation of pro‐inflammatory M1 macrophages into reparative M2 macrophages is a key step in promoting wound healing, leading to the regression of inflammation and the promotion of tissue repair. CD86, the main synergistic factor that induces T lymphocyte proliferation and interleukin‐2 (IL‐2) production, is a characteristic marker of M1 macrophages.…”
Section: Resultsmentioning
confidence: 99%
“…The results suggested that the surface functionalization procedures employed in this study would not induce undesirable morphological changes. The peptide-modified scaffolds could also provide a favorable fibrous structure for cell growth and mechanical support …”
Section: Resultsmentioning
confidence: 99%
“…The peptide-modified scaffolds could also provide a favorable fibrous structure for cell growth and mechanical support. 35 Cell Adhesion and Proliferation on Peptide-Functionalized Electrospun Membranes. The cell adhesion, proliferation, and morphology of HUVECs cultured on various peptide-functionalized membranes with a similar grafting density of approximately 0.16 nmol/cm 2 were evaluated to study the cell−biomaterial interactions.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…Vascular injury, caused by blood flow shear stress, inflammation and fibrosis, is the pathological foundation and causes of multi-cardiovascular diseases. Meanwhile, vascular injury usually occurs after the surgery of arterial occlusive disease, such as carotid endarterectomy, balloon dilatation surgeries and so on [ 12 , 13 ]. The regeneration of injured vascular is a complex but orderly process.…”
Section: The Molecular Mechanism Of Vascular Regeneration After Injurymentioning
confidence: 99%
“…These systems have obvious advantages for systematic delivery of drugs in cardiovascular diseases, e.g. membrane encapsulating drugs at nanoscale can protect them from immune system and increase drug delivery efficiency with low toxicity [ 13 , 70 ]. Due to different cell-derived EVs playing distinct roles in the process of vascular regeneration, it is important to select suitable EV systems for the therapy of vascular injured diseases.…”
Section: The Different Derived Evs For Vascular Therapymentioning
confidence: 99%