Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line

Jiang, Chenyang; Liu, Xin; Li, Chunxue; Qian, Hao-cheng; Chen, Di; Lai, Chao‐Qiang; Shen, Lirong

doi:10.1631/jzus.b1800257

Cited by 21 publications

(21 citation statements)

References 88 publications

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“…MRJP1 is the most abundant among all MRJPs [ 37 , 55 , 56 ]. Due to their high content of amino acids (up to 578), MRJPs are reported to prevent senescence of human cells in vitro [ 57 ] as they promote cell proliferation, cell adhesion, cell growth, and immunity [ 58 , 59 ]. The rest of the protein fraction of RJ comprises antioxidative peptides, free amino acids (including at least eight essential amino acids) [ 55 ], and small amounts of royalisin, jelleines, and aspimin—proteins, which express strong antimicrobial and bactericidal activities even against drug resistant bacteria [ 31 , 32 ].…”

Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Ali

2020

Oxidative Medicine and Cellular Longevity

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The vast increase of world’s aging populations is associated with increased risk of age-related neurodegenerative diseases such as Parkinson’s disease (PD). PD is a widespread disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra, which encompasses a wide range of debilitating motor, emotional, cognitive, and physical symptoms. PD threatens the quality of life of millions of patients and their families. Additionally, public welfare and healthcare systems are burdened with its high cost of care. Available treatments provide only a symptomatic relief and produce a trail of noxious side effects, which increase noncompliance. Hence, researchers have recently focused on the use of nutraceuticals as safe adjunctive treatments of PD to limit its progress and associated damages in affected groups. Propolis is a common product of the beehive, which possesses a large number of therapeutic properties. Royal jelly (RJ) is a bee product that is fed to bee queens during their entire life, and it contributes to their high physical fitness, fertility, and long lifespan. Evidence suggests that propolis and RJ can promote health by preventing the occurrence of age-related debilitating diseases. Therefore, they have been used to treat various serious disorders such as diabetes mellitus, cardiovascular diseases, and cancer. Some evolving studies used these bee products to treat PD in animal models. However, a clear understanding of the collective effect of propolis and RJ as well as their mechanism of action in PD is lacking. This review evaluates the available literature for the effects of propolis and RJ on PD. Whenever possible, it elaborates on the underlying mechanisms through which they function in this disorder and offers insights for fruitful use of bee products in future clinical trials.

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Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Ali

2020

Oxidative Medicine and Cellular Longevity

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“…Other Important Mechanisms in the Management of OA Decreased Cell Aging Rate Different studies have shown that in OA, there is a severe shortening of telomere length [74]. Royal jelly prevents the entry into senescence of different cell groups [75]. Regular consumption of beehive products such as honey, pollen, and propolis reduces the speed with which telomere shortening occurs [76].…”

Section: Mechanisms Of Honey and Pollen In Oamentioning

confidence: 99%

Apitherapy for Osteoarthritis: Perspectives from Basic Research

2020

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Osteoarthritis is one of the most common rheumatic disease in the world and one of the leading causes of disability in the elderly. There is still no curative management for the disease, so the search for new therapeutic alternatives continues. Apitherapy is a therapeutic tool based on the use of beehive products used since ancient times and, at present, their mechanism of action begins to be known. Many of the mechanisms of action of the beehive products are useful for chronic articular pathophysiological processes such as those described in osteoarthritis. This article presents a review of the current state of understanding of the mechanisms through which bee venom, propolis, honey, pollen, and royal jelly may act on osteoarthritis. © 2020 S. Karger AG, Basel Apitherapie bei Osteoarthritis: Perspektiven aus der GrundlagenforschungSchlüsselwörter Apitherapie · Osteoarthritis · Bienengift · Bienenprodukte · Komplementär-und Alternativmedizin ZusammenfassungOsteoarthritis ist eine der weltweit häufigsten rheumatischen Erkrankungen und eine der führenden Ursachen für körperliche Beeinträchtigung im Alter. Eine kurative Behandlungsoption steht bis heute nicht zur Verfügung, daher wird weiter nach therapeutischen Alternativen gesucht. Die Apitherapie ist ein therapeutisches Instrument, das auf der Anwendung von Bienenprodukten beruht, die seit dem Altertum verwendet werden und deren Wirkmechanismen wir gerade beginnen zu verstehen. Viele dieser Mechanismen, über die die Bienenprodukte ihre Wirkung entfalten, spielen eine nützliche Rolle in pathophysiologischen Prozessen von chronischen Gelenkerkrankungen wie zum Beispiel der Osteoarthritis. Dieser Artikel gibt einen Überblick über den aktuellen Kenntnisstand der Mechanismen, über die Bienengift, Propolis, Honig, Pollen und Gelée royale bei Osteoarthritis wirken könnten.

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“…Research documents anti-senescence activity of MRJPs for human cells in vitro [39]. MRJP1 is the most dominant among all MRJPs; essential amino acids constitute 48% of its content.…”

Section: Chemical Composition Of Rjmentioning

confidence: 99%

“…MRJP-treated cells showed the highest proliferation activity, the lowest senescence, and the longest telomeres. Such effects were associated with upregulation of SOD1 and downregulation of mTOR , catenin beta like-1, and tumor protein p53 [39]. Apart from these limited in vitro studies, we could not locate any study that investigated the effect of RJ on lifespan in humans in vivo.…”

Section: Rj Might Enhance Longevity In Humans By Promoting Generalmentioning

confidence: 99%

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

Kunugi

Ali

2019

IJMS

152

154

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Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective natural interventions that can promote healthy aging and extend lifespan. Royal jelly (RJ) is a natural product that is fed to bee queens throughout their entire life. Thanks to RJ, bee queens enjoy an excellent reproductive function and lengthened lifespan compared with bee workers, despite the fact that they have the same genome. This review aimed to investigate the effect of RJ and/or its components on lifespan/healthspan in various species by evaluating the most relevant studies. Moreover, we briefly discussed the positive effects of RJ on health maintenance and age-related disorders in humans. Whenever possible, we explored the metabolic, molecular, and cellular mechanisms through which RJ can modulate age-related mechanisms to extend lifespan. RJ and its ingredients—proteins and their derivatives e.g., royalactin; lipids e.g., 10-hydroxydecenoic acid; and vitamins e.g., pantothenic acid—improved healthspan and extended lifespan in worker honeybees Apis mellifera, Drosophila Melanogaster flies, Gryllus bimaculatus crickets, silkworms, Caenorhabditis elegans nematodes, and mice. The longevity effect was attained via various mechanisms: downregulation of insulin-like growth factors and targeting of rapamycin, upregulation of the epidermal growth factor signaling, dietary restriction, and enhancement of antioxidative capacity. RJ and its protein and lipid ingredients have the potential to extend lifespan in various creatures and prevent senescence of human tissues in cell cultures. These findings pave the way to inventing specific RJ anti-aging drugs. However, much work is needed to understand the effect of RJ interactions with microbiome, diet, activity level, gender, and other genetic variation factors that affect healthspan and longevity.

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Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line

Cited by 21 publications

References 88 publications

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Apitherapy for Osteoarthritis: Perspectives from Basic Research

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

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