2024
DOI: 10.1002/cti2.1525
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Anti‐signal recognition particle antibodies induce cardiac diastolic dysfunction via oxidative stress injury

Hao Zhang,
Yunjing Shi,
Yingze Fan
et al.

Abstract: ObjectivesAnti‐signal recognition particle (SRP) antibodies, markers of immune‐mediated necrotising myopathy, are reportedly related to cardiac involvement; however, whether they are pathogenic to the myocardium remains unclear. We aimed, therefore, to explore the pathogenicity of anti‐SRP antibodies against the myocardium through in vivo and in vitro studies.MethodsTotal immunoglobulin G (IgG), purified from patients with positive anti‐SRP antibodies, was passively transferred into C57BL/6 mice. Cardiac funct… Show more

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