Anti-Staphylococcus aureus activity of methanol extracts of 12 plants used in Cameroonian folk medicine

Fonkeng, Leonard Sama; Mouokeu, Raymond Simplice; Tume, Christopher; Njateng, Guy Sedar Singor; Kamcthueng, Monique Odette; Ndonkou, Nfozon Jinette; Kuiaté, Jules-Roger

doi:10.1186/s13104-015-1663-1

Cited by 15 publications

(12 citation statements)

References 22 publications

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“…Works in the literature have reported C. erecta extracts showed inhibition of the growth Staphylococcus aureus, Escherichia coli, Bacillus subtillis and Pseudomonas aeruginosa. [7][8][9][10][11] In the SciFinder database no reports were found on chemical composition and antioxidant activity of the ethyl acetate and ethanolic extracts from C. erecta stems. In our continuous search for bioactive compounds, this work describes for the first time the phytochemical investigation from the stems of C. erecta.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Study and Antioxidant Evaluation of Commelina erecta (Commelinaceae) Stems

Bezerra¹,

Corrêa²,

Salomé³

et al. 2019

Rev. Virtual Quim.

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Estudo Fitoquímico e Avaliação Antioxidante dos Caules de Commelina erecta (Commelinaceae) Resumo: O estudo fitoquímico dos extratos em acetato de etila e em etanol dos caules de Commelina erecta levou à identificação de luteolina (1), isoquercitrina (7) quercitrina (8), lactona do ácido sacarínico (2), três esteroides glicosilados (3-5) e ácido chiquímico (6). A caracterização química desses compostos foi realizada com base nos dados de EM e RMN, bem como em comparação com a literatura. O presente trabalho é o primeiro relato dessas substâncias em C. erecta. Adicionalmente, revelou esta espécie como uma interessante fonte natural de ácido chiquímico. O teor de fenois totais, juntamente com os ensaios de DPPH e ABTS dos extratos foram também avaliados.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Study and Antioxidant Evaluation of Commelina erecta (Commelinaceae) Stems

Bezerra¹,

Corrêa²,

Salomé³

et al. 2019

Rev. Virtual Quim.

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“…Most of the researchers interpreted the susceptibility results using their in-house standards. For instance, Fonkeng et al mentioned active plant extracts generally possessed MIC range of 500 to 1500 μg/mL against the tested microorganism ( Fonkeng et al, 2015 ). However, Aliyu et al, considered MIC as high as 3000 μg/mL to be active ( Aliyu et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial potential of Malaysian ethnomedicinal plants against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)

Xin

Min

Zin

et al. 2021

Saudi Journal of Biological Sciences

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This study aimed to evaluate the antibacterial activities of 61 plant extracts from 49 Malaysian ethnomedicinal plants and to investigate the interaction of the active plant extracts in combination with synthetic antibiotics against the MSSA and MRSA strains. The minimum inhibitory concentration ( MIC) and minimum bactericidal concentration (MBC) of the plant extracts were determined using a microdilution method against MSSA and MRSA strains. The interaction between active plant extracts and the antibiotics was assessed using the checkerboard method. The total fractional inhibitory concentration (∑FIC) indices from the combination were calculated to determine the nature of the interaction. Out of the 61 plant extracts tested against the MSSA strain, 7 plant extracts (~ 11%) showed MIC values of less than 200 μg/mL, 17 extracts (~ 28%) showed MIC between 200 and 800 µg/mL and seed extracts of Areca catechu showed MBC values of 400 μg/mL. The seed extract of A. catechu showed MIC and MBC of 400 μg/mL against the MRSA strains while leaf extract of Cocos nucifera showed MIC of 400 μg/mL against MRSA NCTC 12493. When the active plant extracts (MIC ≤ 200 µg/mL for MSSA, and ≤ 400 µg/mL for MRSA) were tested in combination with vancomycin and ciprofloxacin, they showed no interaction against both MSSA and MRSA with ∑FIC between 1.06 and 2.03. These findings provide a preliminary overview of the anti-MSSA and anti-MRSA properties of Malaysian ethnobotanical plants to combat Staphylococcal infections. Further research is needed to establish an antibacterial profile of the tested plant extracts.

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“…The hexane leaves crude extract and ethylacetate stem bark showed moderate activity on S. aureus with MIC of 1250 µg/ml (Table 2). Acalypha fruticosa used in treatment of skin infection and diarrhea showed MIC of 512 µg/ml against S. aureus for methanolic leaves extract (Sama Fonkeng et al, 2015).…”

Section: Antimicrobial Assay In Vitromentioning

confidence: 99%

Isolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)

Okwemba¹,

Tarus²,

Machocho³

et al. 2018

J. Med. Plants Res.

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A novel prenylfuroquinoline alkaloid capensenin (1), an alkaloid confusameline (2), two furanocoumarins psolaren (3) and bergapten (4), were isolated from hexane and dichloromethane crude extracts of stem bark, leaves and fruit pericarp of Calodendrum capense. Limonin (5) was also isolated from the stem bark, while limonin diosphenol (6) was isolated from the seeds. Capensenin (1) showed weak antimicrobial activity against Bacillus subtilis, while the leaves, stem bark and fruit pericarp crude extracts exhibited activity against Staphylococcus aureus, B. subtilis and P. citrinum. Hexane pericarp extract showed slight cytotoxicity to Vero cell E199 in 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay. The structures of the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and infra-red spectroscopy.

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Anti-Staphylococcus aureus activity of methanol extracts of 12 plants used in Cameroonian folk medicine

Cited by 15 publications

References 22 publications

Phytochemical Study and Antioxidant Evaluation of Commelina erecta (Commelinaceae) Stems

Phytochemical Study and Antioxidant Evaluation of Commelina erecta (Commelinaceae) Stems

Antibacterial potential of Malaysian ethnomedicinal plants against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)

Isolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)

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