Anti-steroidogenic activity of the petroleum ether extract and fraction 5 (fatty acids) of carrot (Daucus carota L.) seeds in mouse ovary

Majumder, Paramita; Dasgupta, Sudip; Mukhopadhaya, Rupa; Mazumdar, Upal Kanti; Gupta, Malaya

doi:10.1016/s0378-8741(97)00056-1

Cited by 23 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cholesterol and ascorbic acid content in ovaries were significantly elevated by the extract and fraction 5 of carrot seeds. A significant inhibition of delta 5,3-betahydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase (the two key enzymes involved in ovarian steroidogenesis) were also recorded in mouse ovaries after 15 days of treatment [139]. The petroleum ether, alcoholic, and aqueous extracts of Daucus carota were evaluated for their possible antiovulatory activity in rabbits with copper-induced ovulation.…”

Section: Effects On Reproductive Systemsmentioning

confidence: 99%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

View full text Add to dashboard Cite

Abstract:-Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, chlorogenic acid, flavonoids, phenols, essential oil, terpenoid and coumarin. The nutritional analysis of carrot juice showed that the juice contained: protein 1.067 ± 0.058%, crude fat 0.367 ± 0.089%, crude fibre 1.167 ± 0.153%, carbohydrates 6.100 ± 0.346%, many vitamins and minerals. The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastro-protective, nephro-protective, hepato-protective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. The current review highlights the chemical constituents, nutritional and pharmacological effects of Daucus carota.

show abstract

Section: Effects On Reproductive Systemsmentioning

confidence: 99%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

View full text Add to dashboard Cite

show abstract

“…The most abundant phytonutrients present in carrot are phenolics, polyacetylenes, carotenoids, ascorbic acid, and tocopherol. [ 9 ] It was documented that this plant had the potentials of hypotension,[ 10 ] antifertility,[ 11 ] hepatoprotective,[ 12 ] antispasmodic,[ 13 ] antibacterial,[ 14 ] monoamine oxidase inhibition,[ 15 ] and cyclooxygenase enzyme inhibition. [ 16 ] However, traditionally, it was used in the treatment of nephrosis as a nephroprotective agent.…”

Section: Introductionmentioning

confidence: 99%

Carrot (Daucus carota L.): Nephroprotective against gentamicin-induced nephrotoxicity in rats

Sodimbaku¹,

Pujari²,

Mullangi³

et al. 2016

Indian J Pharmacol

View full text Add to dashboard Cite

Objectives:Daucus carota L.(DC) commonly known as carrot, folkorically used as ethnomedicine to treat nephrosis and other urinary disorders. Hence, the present study was aimed to investigate the nephroprotective effects of ethanolic root extract of DC against gentamicin-induced nephrotoxicity in Albino Wistar rats.Methods:Nephrotoxicity in rats was induced by intraperitoneal administration of gentamicin (100 mg/kg/day) for 8 days. Rats of either sex were divided into four groups (n = 6). Group 1 served as control that received normal saline (i.p.) whereas Group 2 (GM) was treated with gentamicin which served as gentamicin-intoxicated group. Group 3–4 (DC200, DC 400) were pretreated with DC at doses of 200 mg/kg and 400 mg/kg (p.o.), respectively, 1 h before the gentamicin intoxication. Following treatment, the nephroprotective effects of DC were evaluated by using serum levels of urea, blood urea nitrogen (BUN), uric acid, and creatinine levels; change in body weight and wet kidney weight along with the histological observations among the experimental groups.Results:Gentamicin intoxication induced elevated serum urea, BUN, uric acid, and creatinine levels which was found to be significantly (P < 0.01) decreased in a dose-dependent manner in groups received DC which was also evidenced by the histological observations.Conclusion:DC showed a significant nephroprotective effect in a dose-dependent manner by ameliorating the gentamicin-induced nephrotoxicity and thus authenticates its ethnomedicinal use.

show abstract

“…Daucus carota L. ssp. carota (wild carrot) is indigenous to Europe and is used as antibacterial, stimulant (Emilio, 1994), antiseptic, carminative, diuretic, hepatoprotective (Bishayee et al, 1995), antisteroidogenic (Majumder et al, 1997), anti-inflammatory (Porchezhian et al, 2000) and in treatment of jaundice and stomach disorders. The seeds of D. carota are used for the treatment of swelling and tumors, while the roots are used as poultice in mammary and uterine carcinoma as well as skin cancer.…”

Section: Introductionmentioning

confidence: 99%