Anti-steroidogenic activity of the two Indian medicinal plants in mice

Gupta, Malaya; Mazumder, Upal Kanti; Vamsi, Madgula Lakshmi Mohan; Sivakumar, T.; Kandar, C.C

doi:10.1016/j.jep.2003.09.002

Cited by 41 publications

(22 citation statements)

References 16 publications

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“…The plant has antifertility, analgesic and antidiabetic properties (Erenmemisoglu et al 1995). Used for antifertility (Gupta et al 2004). Betulinic acid is an antibiotic and antitumor agent (Maurya et al 1989).…”

Section: Indigenous Use (Present Study)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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Section: Indigenous Use (Present Study)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

View full text Add to dashboard Cite

show abstract

“…by the local folks and in many parts of India [3] including SBR, which is one of the grand repository of medicinal plants from eastern part of the country. Looking at the limited studies on bioactivity medicinal plants from SBR [4], an attempt has been made to evaluate the antibacterial and antioxidant properties viz.…”

mentioning

confidence: 99%

In Vitro Antibacterial and Antioxidant Studies of Croton roxburghii L., from Similipal Biosphere Reserve

et al. 2011

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In vitro antibacterial activities of acetone, ethanol, methanol and water extracts of leaves and bark of Croton roxburghii L. studied against ten human pathogenic bacterial strains showed significantly higher activity in acetone extract and least activity in case of aqueous. Minimal inhibitory concentration (MIC) values of all extracts ranged between 0.62 and 10 mg/ml, while minimal bactericidal concentration (MBC) values ranged from 1.25 to values greater than 10 mg/ml. The antioxidant assays viz. DPPH, hydrogen peroxide scavenging, iron reducing and iron chelating assays along with total phenol and ascorbic acid content were carried out with aqueous extracts of leaves and bark. While the total phenol contents in leaves and bark extracts were 0.766 ± 0.014 and 0.735 ± 0.028% respectively their ascorbic acid contents were found to be 0.252 ± 0.019 and 0.431 ± 0.013% respectively. DPPH activities in both (leaves and bark) extracts increased with the increase in concentrations. Iron chelating capacity of leaves extract is significantly higher than that of the bark. Leaves extract showed an increase in percentage of scavenging property with the increase in concentrations. Plant extracts showed low amount of iron reducing property at all concentrations. Hydrogen peroxide scavenging properties of bark was low than that of the leaves.

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“…Ascorbic acid, an easily diffusible water-soluble reductant is found abundantly in testis (Gupta et al, 2004) where it plays an important role in testicular hormonogenesis and the elevation of ascorbic acid content is responsible for inhibition of steroidogenesis. To substantiate these facts, the estimation of G-6-PDH and Δ5-3β-HSD, the two key enzymes involved in steroidogenesis was performed.…”

Section: Discussionmentioning

confidence: 99%

Effects of methanol extracts of Cuscuta reflexa Roxb. stem and Corchorus olitorius Linn. seed on male reproductive system of mice

Pal¹,

Gupta²,

Mazumder³

2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe antifertility activity of methanol extract of Cuscuta reflexa Roxb. stem (MECR) and Corchorus olitorius Linn. seed (MECO) were studied on male Swiss albino mice. The extracts were found to decrease sperm count, percentage of motile sperm and testosterone level in treated mice when compared with vehicle control after 17 days of treatment. The weight of gonads, epididymis were decreased whereas no significant changes of the body weight of mice were observed after methanol extract treatments. The fertility test showed 100% negative result in MECR and MECO treated mice at medium and high dose level of treatment. MECR and MECO in low (25 mg/kg and 15 mg/kg, respectively), medium (50 mg/kg and 20 mg/kg, respectively) and high (75 mg/ kg and 25 mg/kg, respectively) dose level caused a simultaneous fall in testicular Δ5-3β-hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase activities which are involved in testicular steroidogenesis. Total cholesterol and ascorbic acid content in testis were increased significantly in gonads. The activities of lactate dehydrogenase, malic dehydrogenase and ascorbic acid oxidase were reduced whereas that of carbonic anhydrase was increased significantly in the testis of MECR and MECO treated mice. All these observations indicate that the methanol extract of C. reflexa stem and C. olitorius seed produced antifertility activity in sexually matured male mice, which may be due to inhibition of gonadal steroidogenesis. This activity may be attributed due to the presence of flavonoids and steroids, respectively.

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Anti-steroidogenic activity of the two Indian medicinal plants in mice

Cited by 41 publications

References 16 publications

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

In Vitro Antibacterial and Antioxidant Studies of Croton roxburghii L., from Similipal Biosphere Reserve

Effects of methanol extracts of Cuscuta reflexa Roxb. stem and Corchorus olitorius Linn. seed on male reproductive system of mice

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