Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress

Kojima, Hiroshi; Yao, Xin‐Sheng; Nagai, Hirokazu; Tsuruoka, Nobuo; Shibata, Hiroshi; Kiso, Yoshinobu; Fukami, Hironobu

doi:10.1248/jhs.52.252

Cited by 17 publications

(20 citation statements)

References 20 publications

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“…In research, different types of stress have been applied on animals to study their influences on glucose metabolisms, including endoplasmic reticulum stress, oxidative stress, restraint stress, and so on (34 -36). The present study employed a 20-h restraint stress to study its effects on glucose metabolism in mice (26). Results showed that restraint stress lead to glucose metabolism disorder in mice, which was reflected by abnormal glucose tolerance level, lowered glucose elimination rate, and decreased hepatic and muscle glycogen contents.…”

Section: Discussionmentioning

confidence: 87%

Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice

Tsoi

Yang

et al. 2011

J Pharmacol Sci

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Abstract. Carnosine is a natural dipeptide that has shown multiple benefits in the treatment of various diseases. This study investigated the ameliorative effects of carnosine on glucose metabolism in restraint-stressed mice. Our results showed that restraint stress could significantly influence glucose metabolism, as reflected by lowered glucose tolerance, hepatic and muscle glycogen content, and increased plasma corticosterone concentration in mice. Oral administration of carnosine (150 and 300 mg/kg) not only reverted stress-induced decline in glucose tolerance and glycogen content in liver and muscle, but also reduced plasma corticosterone level. Carnosine has also significantly suppressed mRNA expression of glucose-6-phosphatase, while elevating glycogen synthase 2, glucokinase and glucose transporter 2 expressions in the liver. The obtained results demonstrated the harmful effects induced by restraint stress, while proving that carnosine could ameliorate stress-induced glucose metabolism disturbance. It is presumable that carnosine exerts its anti-stress effects by indirectly affecting the histaminergic neuron system, modulating the stress-activated hypothalamic-pituitary-adrenal axis and improving glucose metabolism through regulation of the enzymes in the glucose metabolic pathways.

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Section: Discussionmentioning

confidence: 87%

Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice

Tsoi

Yang

et al. 2011

J Pharmacol Sci

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“…Moreover, Ricart-Jané's study (3) indicated that stress caused lipid energy-substrate redistribution between tissues, which was required for the fight-or-flight response. Other studies also indicated that stress limited the supply of energy, which lead to poor utilization of biological energy sources, neurological or tissue dysfunctions, and resulted in tiredness and various other physiological disorders (4,5). Stress is also well known for its direct influences on the central nervous system (6).…”

Section: Introductionmentioning

confidence: 99%

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Yao

Wang

et al. 2009

J Pharmacol Sci

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Abstract. The present study was conducted to investigate the effects of histamine on the lipid metabolic disorder in mice loaded with restraint stress. When Kun Ming (KM) mice were exposed to restraint stress for 20 h, the histamine level in both plasma and cerebral regions significantly increased (P<0.01). Moreover, when a lipid emulsion (10% Intralipid ® ) was injected intravenously into the mice, the elimination period of plasma triglyceride was prolonged in the restraint group. Plasma triglyceride was 523 ± 44 mg/dl at 35 min after the Intralipid ® administration in the restraint stress group, while it was 436 ± 41 mg/dl in the restrained mice given histamine at a dose of 50 mg/kg. The improved plasma triglyceride metabolism was well explained by the observations of the significantly up-regulated hepatic triglyceride lipase (HTGL) activity and mRNA expression in response to histamine. These results suggested that the effects of stress-induced histamine on lipid metabolic disorder in mice loaded with restraint stress arose from its anti-stress action and promotion of lipase activity.

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“…Human study demonstrated such effects as improvement of nasal mucus secretion, 3) sustaining strength in strenuous, repetitive exercise, 4) enhancement of the metabolic rate, 5,6) improvement of the serum iron level recovery after blood donation, 7) increases in beneficial contents in maternal milk, 8) and improvement of skin conditions. 9) Furthermore, in animal studies, inhibition of blood pressure increase 10,11) and attenuation of stress-induced response such as a decrease in blood glucose and lipid metabolism 12,13) have been reported. Thus, scientific evidence on the healthful effects of chicken soup or extract is gradually accumulating.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chicken Soup Intake on Mood States and Peripheral Blood Flow in Humans

Midoh

Noguchi

2009

JOURNAL OF HEALTH SCIENCE

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Chicken soup has long been considered anecdotally healthful in Western and Southeast Asian countries. In this study, we examined the effects of a 2-week intake of chicken soup on mood states and of a single and 2-week intake on peripheral blood flow. Thirty healthy volunteers (7 men and 23 women aged 20.5 ± 1.4 years) participated in a randomized, double-blind, placebo-controlled crossover study with 2 weeks treatment and washout periods. They were randomly assigned to two groups, and daily received either chicken soup or placebo soup. Mood states by the Profile of Mood States (POMS) questionnaire and peripheral blood flow by a laser-Doppler blood flow imaging system were assessed before and after each treatment period. On the first day of the treatment periods, the effect of single intake on peripheral blood flow was investigated. The 2-week intake of chicken soup significantly reduced the tension-anxiety (T-A) score compared to the placebo soup (p < 0.05). The single intake of chicken soup significantly increased peripheral blood flow as compared with the base value (20 min after intake p < 0.01; 25, 30 and 45 min after intake p < 0.001) and that of the placebo soup (25, 30 and 60 min after intake p < 0.05; 45 min after intake p < 0.01). The 2-week intake of chicken soup also significantly increased peripheral blood flow over that of the placebo soup (p < 0.001). Chicken soup was considered to have improved mood states such as tension and anxiety and increased peripheral blood flow.

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Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress

Cited by 17 publications

References 20 publications

Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice

Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Effect of Chicken Soup Intake on Mood States and Peripheral Blood Flow in Humans

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