Anti‐T Agglutinin in Cirrhosis of the Liver

Boccardi, V; Attinà, Domenico; Bigliocchi, S.; Girelli, Gabriella

doi:10.1111/j.1423-0410.1974.tb02670.x

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…However, all pneumococcal infections do not result in Tactivation. Individual variations in the anti-T titer in patients compared with normal individuals have been reported [36,37]. This was attributed to the presence or absence of intestinal flora able to express a molecule either identical or very similar to the T-antigen, thereby stimulating anti-T antibody production [38,39,40].…”

Section: Discussionmentioning

confidence: 95%

Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia

Cochran

Panzarino

Maes

et al. 2004

Pediatric Nephrology

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The hemolytic uremic syndrome (HUS) is most commonly associated with Escherichia coli, but has been associated with other infections such as Streptococcus pneumoniae. Pneumococcus-induced HUS carries an increased risk of mortality and renal morbidity compared with E. coli-induced HUS. The pneumococcal organism produces an enzyme, which can expose an antigen (T-antigen) present on erythrocytes, platelets, and glomeruli. Antibodies to the T-antigen, normally found in human serum, bind the exposed T-antigen, and the resultant antigen-antibody reaction (T-activation) can lead to HUS and anemia. Clinicians need to be aware to request specific testing when pneumococcus-induced HUS/anemia is suspected, as current blood banking techniques do not routinely test for the presence of the T-antigen. Once this association is documented, washing all blood products and avoiding plasma products, if possible, is recommended. Plasmapheresis can be considered for the more critically ill patient. The incidence of pneumococcus-induced HUS may be increasing. We report six cases of pneumococcus-induced HUS/anemia presenting at our hospital.

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Section: Discussionmentioning

confidence: 95%

Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia

Cochran

Panzarino

Maes

et al. 2004

Pediatric Nephrology

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“…Assuming that most y-globulins are antibodies, both hypotheses would explain the hypergammaglobulinaemia frequently encountered in chronic liver disease. We have recently observed in cirrhotic patients raised levels of anti-T agglutinin, the antibody directed against a cryptoantigenic structure of red blood cells [4]; in the present study we determined anti-T titre in normal subjects and in some cirrhotic patients…”

mentioning

confidence: 86%

“…Titrations were carried out in double saline dilutions, with macroscopic readings after 2 h incubation at room temperature. All samples were tested simultaneously and before testing they were kept stored at -3O"C, as previous work [4] had shown that anti-T titre remains unmodified after some months preservation at such temperature. Serum protein and y-globulin levels were also estimated in all subjects.…”

Section: ~~mentioning

confidence: 99%

Influence of Orally Administered Antibiotics on anti-T Agglutinin of Normal Subjects and of Cirrhotic Patients

Boccardi¹,

Attinà²,

Girelli³

1974

Vox Sanguinis

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Anti-T agglutinin was studied in normal healthy subjects and in cirrhotic patients before and after oral administration of antibiotics depressing intestinal microbial flora. After antibiotic treatment anti-T levels were significantly reduced. These observations show that bacterial antigens of intestinal origin are likely to be responsible for anti-T production and that there must be common determinants between them and T antigen of red blood cells. It is not sure whether the previously reported increase of anti-T levels in liver cirrhosis is in favour of the hypothesis that hypergammaglobulinaemia in this condition is due to failure of diseased liver to trap gut-derived antigens.

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Detection of lung- and breast carcinoma by quantitating serum anti-T IgM levels with a sensitive, solid-phase immunoassay

Springer

Desai

1982

Naturwissenschaften

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Anti‐T Agglutinin in Cirrhosis of the Liver

Abstract: Anti-T agglutinin has been studied in 44 cases of liver cirrhosis and 2 of chronic active hepatitis. The antibody titre was sisnificantly higher than in normal controls. No correlation was found between anti-T titre and y-globulin level or clinical conditions.

Cited by 5 publications

References 9 publications

Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia

Pneumococcus-induced T-antigen activation in hemolytic uremic syndrome and anemia

Influence of Orally Administered Antibiotics on anti-T Agglutinin of Normal Subjects and of Cirrhotic Patients

Detection of lung- and breast carcinoma by quantitating serum anti-T IgM levels with a sensitive, solid-phase immunoassay

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