Anti-thyroid antibodies and cerebrospinal fluid findings in neuromyelitis optica spectrum disorders

Li, Haiyan; Dai, Yongqiang; Wu, Ai-Min; Sun, Xiaobo; Lin, Yinyao; Lv, Kefeng; Liu, Zhengqi

doi:10.1016/j.jneuroim.2015.02.014

Cited by 17 publications

(5 citation statements)

References 35 publications

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“…Intriguingly, we found that TPO-Ab and TG-Ab positivity were less frequently observed in MOGAD patients (13.9%, 13.9%). What is noteworthy is that the existing studies have highlighted that a significant difference in the incidence of positive ATAbs between NMOSD patients and healthy subjects and indicated that a potential association between ATAbs status and various clinical outcomes, including disability status, EEG abnormalities, and longitudinally extensive spinal cord lesions (Li et al, 2015 ; Huo et al, 2022 ). However, our study did not replicate these findings.…”

Section: Discussionmentioning

confidence: 99%

Low T3 syndrome is associated with the severity of myelin oligodendrocyte glycoprotein antibody-associated disease exacerbation

Wu,

Zhou,

et al. 2024

Front. Neurosci.

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BackgroundMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare autoimmune inflammatory disease of the central nervous system, (CNS) different from multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). While numerous studies have delved into the involvement of thyroid antibodies (ATAbs) and thyroid function in NMOSD and MS. The objective of this study is to explore the clinical significance of thyroid dysfunction and ATAbs abnormalities in adult patients with MOGAD.Methods36 adult inpatients diagnosed with MOGAD and 47 sex- and age-matched healthy controls were enrolled. Patients were divided into two groups based on the presence or absence of low T3 syndrome. Demographics, clinical characteristics, and results of auxiliary examinations were compared across the subgroups. Moreover, an analysis was conducted to explore the correlations between thyroid hormone levels and Expanded Disability Status Scale (EDSS) scores.ResultsThyroid dysfunction was notably more frequent in MOGAD patients than healthy controls (p < 0.0001), particularly low T3 syndrome (p=0.03). Furthermore, subgroup analyses revealed that the low T3 syndrome group exhibited higher EDSS scores and a higher proportion of individuals with EDSS scores > 3, in comparison to the non-low T3 syndrome group (p = 0.014, p = 0.046). However, no significant differences were observed in demographic characteristics, annual relapse rates, clinical phenotypes, laboratory and MRI results, and EEG abnormalities between the two groups. Additional Spearman's analysis showed significantly negative correlations between the TT3 and FT3 levels with EDSS scores (r = −0.367, p = 0.028; r = −0.377, p = 0.024). Typical brain lesions and paralateral ventricle lesions were significantly rare in patients with positive ATAbs compared to those with negative ATAbs (p = 0.0001, p = 0.03), although the incidence of ATAbs abnormalities did not differ significantly between MOGAD patients and healthy controls.ConclusionsOverall, this study confirmed thyroid dysfunction, especially low T3 syndrome, is frequent in adult MOGAD patients. Patients with low T3 syndrome exhibited elevated EDSS scores and a significantly higher incidence of unfavorable condition. additionally, the correlation analysis model manifests that FT3 and TT3 levels were negatively correlated with EDSS scores. These evidences indicate that low T3 syndrome is associated with the severity of MOGAD exacerbation.

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Section: Discussionmentioning

confidence: 99%

Low T3 syndrome is associated with the severity of myelin oligodendrocyte glycoprotein antibody-associated disease exacerbation

Wu,

Zhou,

et al. 2024

Front. Neurosci.

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“…The intact ellipsoid zone of the patient's fovea indicates other causes for the VA decrease. The suspicion of optic neuritis was raised by the rapid progression of the VA decrease, the demyelinating foci on the MRI, and the abnormality of the autoantibodies [ 12 ]. The rapid response to corticosteroid therapy and the recovery of VEP further confirmed the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Retinitis Pigmentosa and Bilateral Idiopathic Demyelinating Optic Neuritis in a 6-Year-Old Boy with OFD1 Gene Mutation

Wang

Zheng

et al. 2017

Case Reports in Ophthalmological Medicine

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To identify the cause of a sudden binocular vision decrease in patients with retinitis pigmentosa and bilateral idiopathic demyelinating optic neuritis is difficult, but early diagnosis and treatment significantly improve the prognosis. Here, we report a 6-year-old boy with a progressive binocular vision decrease in 38 days. The patient had a history of night blindness, a mottled retina without pigmentation, extinguished electroretinographic response, tritanopia, and an absent ellipsoid zone outside the macula fovea by optical coherence tomography in both eyes. His condition was diagnosed as retinitis pigmentosa (RP) with idiopathic demyelinating optic neuritis (IDON). After corticosteroid therapy, visual acuity recovered to OD: 0.5 and OS: 0.4. Genetic analysis revealed a G985S variant in the oral-facial-digital syndrome 1 gene. Ophthalmologists should pay attention to the existence of other complications in patients with RP who suffer a sudden decrease in vision. A gene survey can help clarify this diagnosis. To our knowledge, this is the first report of a patient with RP and ON, as well as genetic testing results. Nevertheless, the pathogenicity of the variant needs further confirmation.

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“…В качестве подобных аутоантител при РС и АИТ рассматривают перекрестно-реагирую-щие аутоантитела к липидам миелина [77]. Косвен-ным доказательством сходства патогенеза РС с АИЗ ЩЖ и различия с системными заболеваниями со-единительной ткани является более легкое течение демиелинизирующих заболеваний при наличии ан-тинуклеарных антител и более тяжелое их течение при наличии антитиреоидных антител [78][79][80].…”

Section: аутоиммунные заболевания возникающие на фоне применения разunclassified

Comorbid autoimmune pathology in patients treated with disease modifying drugs

Гончарова

Sizyakinа

Belovolova

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Anti-thyroid antibodies and cerebrospinal fluid findings in neuromyelitis optica spectrum disorders

Cited by 17 publications

References 35 publications

Low T3 syndrome is associated with the severity of myelin oligodendrocyte glycoprotein antibody-associated disease exacerbation

Low T3 syndrome is associated with the severity of myelin oligodendrocyte glycoprotein antibody-associated disease exacerbation

Retinitis Pigmentosa and Bilateral Idiopathic Demyelinating Optic Neuritis in a 6-Year-Old Boy with OFD1 Gene Mutation

Comorbid autoimmune pathology in patients treated with disease modifying drugs

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