Anti-Tick Vaccines: Current Advances and Future Prospects

Muhanguzi, Dennis; Ndekezi, Christian; Nkamwesiga, Joseph; Kalayou, Shewit; Ochwo, Sylvester; Lobb, Kevin A.; Kimuda, Magambo Phillip

doi:10.1007/978-1-0716-1888-2_15

Cited by 13 publications

(12 citation statements)

References 53 publications

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“…Modern methods for vaccine production, for example using recombinant proteins, mRNA-or DNA-based techniques [212,213], can also be used for the development of vaccines against ticks [214].…”

Section: Using Innate and Adaptive Immunity For Vaccine Developmentmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

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Summary Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the pharmacological importance of which is increasingly being recognized. Many bioactive substances in tick saliva are being considered as the basis of new drugs. For example, components of tick cement can be developed into tissue adhesives or wound closures. Analgesic and antipruritic salivary components inhibit histamine or bradykinin, while other tick‐derived molecules bind opioid or cannabinoid receptors. Tick saliva inhibits the extrinsic, intrinsic, or common pathway of blood coagulation with implications for the treatment of thromboembolic diseases. It contains vasodilating substances and affects wound healing. The broad spectrum of immunomodulatory and immunosuppressive effects of tick saliva, such as inhibition of chemokines or cellular immune responses, allows development of drugs against inflammation in autoimmune diseases and/or infections. Finally, modern vaccines against ticks can curb the spread of serious infections. The medical importance of the complex tick‐host interactions is increasingly being recognized and translated into first clinical applications. Using selected examples, an overview of the mutual adaptations of ticks and hosts is given here, focusing on their significance to medical advance.

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Section: Using Innate and Adaptive Immunity For Vaccine Developmentmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

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“…The research applications in proteomics range from early growth and development to postmortem events important for meat quality (Yarmush and Jayaraman, 2002;Bendixen, 2005). One of the major areas of interest in proteomics is finding out robust protein biomarkers that could be useful in disease surveillance, monitoring the health and wellbeing of animals, elucidating disease mechanisms, and assessing pharmacologic response to therapeutics (Oskoueian et al, 2016) (Muhanguzi et al, 2022). Proteomics can also be applied for different animal products post-harvest like meat, milk, cheese, etc., to identify genetic variants with desirable traits for selection and breeding (Almeida et al, 2015).…”

Section: Proteomicsmentioning

confidence: 99%

Applications of Omics Technology for Livestock Selection and Improvement

et al. 2022

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Conventional animal selection and breeding methods were based on the phenotypic performance of the animals. These methods have limitations, particularly for sex-limited traits and traits expressed later in the life cycle (e.g., carcass traits). Consequently, the genetic gain has been slow with high generation intervals. With the advent of high-throughput omics techniques and the availability of multi-omics technologies and sophisticated analytic packages, several promising tools and methods have been developed to estimate the actual genetic potential of the animals. It has now become possible to collect and access large and complex datasets comprising different genomics, transcriptomics, proteomics, metabolomics, and phonemics data as well as animal-level data (such as longevity, behavior, adaptation, etc.,), which provides new opportunities to better understand the mechanisms regulating animals’ actual performance. The cost of omics technology and expertise of several fields like biology, bioinformatics, statistics, and computational biology make these technology impediments to its use in some cases. The population size and accurate phenotypic data recordings are other significant constraints for appropriate selection and breeding strategies. Nevertheless, omics technologies can estimate more accurate breeding values (BVs) and increase the genetic gain by assisting the section of genetically superior, disease-free animals at an early stage of life for enhancing animal productivity and profitability. This manuscript provides an overview of various omics technologies and their limitations for animal genetic selection and breeding decisions.

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“…The use of proteomic approaches for studying reproductive problems has dramatically increased in the past decade ( Peddinti, Memili & Burgess, 2011 ). Targeting robust protein markers is useful in disease monitoring, surveillance, health monitoring, and overall well-being of the animal which will help assess pharmacologic response to therapeutics ( Muhanguzi et al., 2022 ). Proteomics is used to identify genetic variants with traits desirable for breeding and selection for various animal products post-harvest like milk, meat, cheese, etc.…”

Section: Nutrigenomics In the Livestock Sectormentioning

confidence: 99%