Anti-TJa Alloimmunization (anti-PP1Pk)

Abstract

Anti-TJa alloimmunization is an extremely rare condition which can cause miscarriages during the first and second terms of pregnancy. At 20-year-old female patient, an anti-TJa carrier, was given plasma transfusions in the course of her first two pregnancies. The cordocentesis, which was the main follow-up test during the first pregnancy, could not be carried out during the second pregnancy due to the presence of a huge subchorionic hematoma. Both pregnancies were characterized by fetal growth retardation, which was particularly considerable in one. Due to chronic fetal distress, both infants were delivered prematurely by cesarean section. The immunohematological data concerning anti-TJa alloimmunization and the different palliative treatments available to date are reviewed.

Recurrent miscarriage associated with rare anti-PP1Pk antibody: a case series and literature review

“…Plasmapheresis can reduce the anti-PP1Pk antibody titer to prevent miscarriage. Trophoblast cells can express antigens in the rst trimester, so plasmapheresis should be started at 5-7 weeks gestation to reduce the antibody titer to between 1:16 and 1:32 [22]. Plasmapheresis is usually performed using a centrifugal plasma separator for simple plasmapheresis, while some studies have found that double-ltration plasmapheresis is safer for pregnant women [26].…”

Multiple miscarriages in two sisters of Thai origin with the rare Pk phenotype caused by a novel nonsense mutation at the B3GALNT1 locus

“…Several studies have reported the successful therapeutic use of plasmapheresis in removing cytotoxic anti‐P from maternal plasma (Yoshida et al, ; Rock et al, ). However, this line of treatment is most successful if started as early as possible in the first trimester, when P antigens first appear on the trophoblastic tissue, and is continued throughout the second trimester (Haentjens‐Verbeke et al, ). Plasmapheresis has to be undergone several times a week, making it hard to manage in remote areas.…”