2019
DOI: 10.1155/2019/4038619
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Anti-TNF-α Monoclonal Antibody Therapy Improves Anemia through Downregulating Hepatocyte Hepcidin Expression in Inflammatory Bowel Disease

Abstract: Anemia is one of the most common complications in patients with inflammatory bowel disease (IBD). Hepcidin as a key regulator of iron metabolism is pivotal in mediating the occurrence of anemia of chronic disease. Herein, we analyzed the levels of hepcidin in sera from IBD patients by enzyme-linked immunosorbent assay and investigated its potential role in regulating the anemia in IBD. We observed that the levels of serum hepcidin were increased in active IBD patients compared with those in remitted IBD patien… Show more

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Cited by 21 publications
(34 citation statements)
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“…HAMP expression is also downregulated by hypoxia and erythropoietin (EPO) through erythroferrone (ERFE) to allow iron mobilization for erythropoiesis, while it is upregulated by inflammation. IL-6 is the main signal that induce HAMP during inflammation, through the JAK/STAT3 pathway in association with the BMP/SMAD pathway, but also IL-1β and TNF-α have a direct role on HAMP regulation [95,128,129]. As stated above, CQ/HCQ not only interfere with cellular iron inducing its starvation in alveolar macrophages [122,123], then possibly resulting in a switch to M2 anti-inflammatory state, but also inhibit IL-6, IL-1β and TNF-α release, possibly reducing local HAMP release by macrophages.…”
Section: Cq/hcq May Induce Cellular Iron Starvation: a Potential Benementioning
confidence: 99%
“…HAMP expression is also downregulated by hypoxia and erythropoietin (EPO) through erythroferrone (ERFE) to allow iron mobilization for erythropoiesis, while it is upregulated by inflammation. IL-6 is the main signal that induce HAMP during inflammation, through the JAK/STAT3 pathway in association with the BMP/SMAD pathway, but also IL-1β and TNF-α have a direct role on HAMP regulation [95,128,129]. As stated above, CQ/HCQ not only interfere with cellular iron inducing its starvation in alveolar macrophages [122,123], then possibly resulting in a switch to M2 anti-inflammatory state, but also inhibit IL-6, IL-1β and TNF-α release, possibly reducing local HAMP release by macrophages.…”
Section: Cq/hcq May Induce Cellular Iron Starvation: a Potential Benementioning
confidence: 99%
“…Factors affecting iron levels in IBD patients are shown in Figure 1 below. The effect of inflammation in IBD (inflammatory bowel disease) is mainly mediated by hepcidin [24]. Hepcidin is a peptide hormone produced in the liver.…”
Section: Iron Metabolismmentioning
confidence: 99%
“…It is a direct inhibitor of ferroportin-a protein that transports iron beyond the cells that store it. The hepcidin-FPN (ferroportin) axis is considered to be the main regulator of iron homeostasis [24]. Inhibited ferroportin, present on enterocytes and macrophages, inhibits the transport of iron from enterocytes to the hepatic portal vein system, thus reducing iron absorption.…”
Section: Iron Metabolismmentioning
confidence: 99%
See 1 more Smart Citation
“…The invading pathogens and the hosts compete for the use of iron [6]. In acute infectious diseases, including bacteria (such as S. Typhi [8]), fungi [7] (such as C.glabrata, C.albicans, A.fumigatus and C.neoformans) and virus (such as coronavirus disease 2019, COVID-19 [9]), in ammatory factors, such as IL-6, could increase the expression of hepcidin to promote the degradation of the iron exporter ferroportin in duodenal enterocytes and macrophages [10][11][12][13][14], which could decrease the serum iron concentration by restricting iron uptake and macrophage iron release [15]. The dysregulation of iron release by macrophages could contribute to the survival of intracellular, macrophage-tropic bacteria [13], but could be detrimental to the extracellular pathogens [8,16,17].…”
Section: Introductionmentioning
confidence: 99%