Anti-TNF therapy: Safety aspects of taking the risk

Rosenblum, Hemda; Amital, Howard

doi:10.1016/j.autrev.2011.04.010

Cited by 111 publications

(77 citation statements)

References 79 publications

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“…For example, vitamin D3 stimulation of osteoclasts in vitro is enhanced by T-cell depletion (30); removing T cells would also remove any OX40 expressed by them. CD8 + T cells are also antiosteoclastogenic (15,31) and express high levels of OX40 during infections (32-34) associated with arthritic disease flare (35).…”

Section: Resultsmentioning

confidence: 99%

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

Findlay

Danks²,

Madden

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance Current therapies to alleviate autoimmune conditions use global strategies that affect large compartments of the immune response. These strategies mop up the excesses of disease without slowing disease progression and carry a significant risk of infection. This article describes the selective inhibition of autoaggressive T cells with the ability to regress established arthritis and reveals an unexpected role for an immune receptor–ligand pair in bone homeostasis.

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Section: Resultsmentioning

confidence: 99%

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

Findlay

Danks²,

Madden

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Özellikle RA hastalar›nda yap›lan baz› çal›flmalar anti-TNF-α tedavisi alan hastalarda malignite s›kl›¤›nda art›fl bildirmifl ancak bu durum kesin olarak do¤rulanamam›fl-t›r. [1,6,20,[28][29][30] Buna karfl›n ço¤u çal›flma melanoma d›fl› cilt kanserlerinin bu ilaçlar› kullanan hastalarda artt›¤› konusunda hemfikirdir. [30][31][32][33] Bizim çal›flmam›zda 2 hastada malignite gözlendi.…”

Section: Tart›flmaunclassified

The analysis of ankylosing spondylitis patients receiving biological therapies: data from TURKBIO registry

Güllüoğlu¹

2014

RAED Derg

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“…Background TNF-alpha inhibitors brought a new era for treatment of severe patients with psoriasis. However, a significant percentage shows disease relapse during long-term therapy (1,2). Preventing unnecessary treatment failure with biologics necessitates reliable predictive markers of long-term therapy effectiveness.…”

Section: Supporting Informationmentioning

confidence: 99%

Cutaneous lymphocyte‐associated antigen as a novel predictive marker of TNF‐alpha inhibitor biological therapy in psoriasis

Jókai

Szakonyi

Kontár

et al. 2013

Experimental Dermatology

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system and IL-13, IL-17E/IL-25 as well as COX-2 might be key factors to aggravate Ag-induced AD-like symptoms. AcknowledgementsThis study was supported by a grant from the Korean Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A091121). Author contributionsJi-Yun Kim performed the research, designed the research study, analysed the data and wrote the paper; Mi Sook Jeong performed the research and analysed the data; Kui Young Park designed the research study and analysed the data; Seong Jun Seo designed the research study, analysed the data and wrote the paper. Ethics approval for animal careAll experiments with mice were performed in accordance with the regulations and the approval of the Institutional Animal Care and Use Committee of Chung-Ang University (Approval No. 10-1011) and Korea Conformity Laboratories (KCL). Conflict of interestsThe authors have declared no conflicting interests. Supporting InformationAdditional Supporting Information may be found in the online version of this article: Data S1. Supplementary Materials and Methods. Figure S1. Effects of FA inhalation on the clinical skin severity score and the infiltration of inflammatory cells in ear skin of NC/Nga mice. Table S1. Effect of FA inhalation on the production of total levels of immunoglobulin (Ig) isotypes in plasma. Table S2. Effect of FA inhalation on the protein expressions of cytokines in splenocytes. Abstract: A considerable number of patients with psoriasis show secondary resistance during long-term TNF-alpha inhibitor therapy, necessitating the identification of reliable predictive markers. Predictive role of cutaneous lymphocyte-associated antigen (CLA) was investigated. Thirty-eight severe patients with psoriasis were treated for a 24-week-long study period. Clinical responsiveness (PASI) and changes in flow cytometry-measured peripheral lymphocyte CLA expression (week 0-2-6) were statistically analysed. Regarding 24-week-long treatment outcome patients were divided into two groups: During the first 6 weeks, mean CLA expression showed significant (P = 0.034604) increase among responders (32/38), while after a preliminary increase, it was significantly (P = 0.012539) decreasing in the relapsing group (6/38). Pearson's correlation analysis showed significant negative correlation between PASI and CLA changes. Responders showed (not significantly) lower initial CLA expression than relapsing patients. Our observations suggest change in CLA expression during the first 6 weeks of induction period to serve as a potential predictive marker of TNF-alpha inhibitor therapy in psoriasis.

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Anti-TNF therapy: Safety aspects of taking the risk

Cited by 111 publications

References 79 publications

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis

The analysis of ankylosing spondylitis patients receiving biological therapies: data from TURKBIO registry

Cutaneous lymphocyte‐associated antigen as a novel predictive marker of TNF‐alpha inhibitor biological therapy in psoriasis

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