Anti-toxoplasmosis Effects of Oleuropein Isolated from Fraxinus rhychophylla

Jiang, Jeng Kai; Jin, Chi; Kim, Youn‐Chul; Kim, Hun-Soo; Park, Won-Cheol; Park, Hyun

doi:10.1248/bpb.31.2273

Cited by 38 publications

(17 citation statements)

References 13 publications

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“…Diverse compounds have been isolated from the plant. Among them, ferulaldehyde and scopoletin have inhibitory activity against induction of inducible NO synthase (66), and antitoxoplasmosis effect of oleuropein was reported (57). During the course of characterizing biologically active compounds from natural products, two major coumarins were isolated, esculetin and fraxetin (Fig.…”

Section: Other Compounds and Plant Extractsmentioning

confidence: 99%

Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

Barbagallo

Galvano

Frigiola

et al. 2013

Antioxidants & Redox Signaling

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Significance: Many physiological effects of natural antioxidants, their extracts or their major active components, have been reported in recent decades. Most of these compounds are characterized by a phenolic structure, similar to that of a-tocopherol, and present antioxidant properties that have been demonstrated both in vitro and in vivo. Polyphenols may increase the capacity of endogenous antioxidant defenses and modulate the cellular redox state. Such effects may have wide-ranging consequences for cellular growth and differentiation. Critical Issues: The majority of in vitro and in vivo studies conducted so far have attributed the protective effect of bioactive polyphenols to their chemical reactivity toward free radicals and their capacity to prevent the oxidation of important intracellular components. One possible protective molecular mechanism of polyphenols is nuclear factor erythroid 2-related factor (Nrf2) activation, which in turn regulates a number of detoxification enzymes. Recent Advances: Among the latter, the heme oxygenase-1 (HO-1) pathway is likely to contribute to the established and powerful antioxidant/anti-inflammatory properties of polyphenols. In this context, it is interesting to note that induction of HO-1 expression by means of natural compounds contributes to prevention of cardiovascular diseases in various experimental models. Future Directions: The focus of this review is on the role of natural HO-1 inducers as a potential therapeutic strategy to protect the cardiovascular system against various stressors in several pathological conditions. Antioxid. Redox Signal. 18, 000-000.

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Section: Other Compounds and Plant Extractsmentioning

confidence: 99%

Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

Barbagallo

Galvano

Frigiola

et al. 2013

Antioxidants & Redox Signaling

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“…Antiviral activity against herpes mononucleosis, hepatitis virus, rotavirus, respiratory syncytial virus and parainfluenza type 3 virus is also attributed to oleuropein (4). In terms of antiparasitic effects, oleuropein has been found to show leishmanicidal activity as well as anti-toxoplasmic activity (14,15). To the best of our knowledge, this study is the first in which oleuropein is isolated and used as a single active ingredient in terms of protoscolicidal activity.…”

Section: Discussionmentioning

confidence: 85%

Protoscolicidal effect of oleuropein: an in vitro study

Arslan¹,

Özant²,

Özçay³

et al. 2019

Turk J Surg

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Objective: Hydatid disease is a parasitic disease caused by Echinococcus granulosus and is still endemic in many parts of the world. Scolicidal solutions are generally used in any type of intervention, either surgical or percutaneous, to neutralize the cyst contents, although completeness of their effect is obscure and solid evidence is scarce. On the other hand, the use of these scolicidal solutions is not devoid of complications and many serious complications such as caustic sclerosing cholangitis may be seen in relation with their usage. Recent investigations proved protoscolicidal properties of olive leaf extract although the active ingredient has not been attributed to any component. The aim of this experimental study was to isolate oleuropein and test for in vitro protoscolicidal activity. Material and Methods: Oleuropein, a phenolic compound found in olive leaves, is extracted and prepared in different concentrations. Echinococcal cyst containing livers of sheep are obtained from the government slaughterhouse. Cysts were punctured and live protoscolex suspensions were prepared under aseptic conditions. Different concentrations of oleuropein solutions were prepared and protoscolicidal property is analyzed and compared with positive and negative controls for different exposure times. Results: Oleuropein 2% concentration was found to be protoscolicidal in all exposure times starting from 5 minutes. Conclusion: 2% oleuropein is a powerful, natural protoscolicidal agent which should be evaluated clinically before its application in routine treatment practice.

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“…Particularly in the case of Zingiber officinale, the value of EC 50 (half maximal effective concentration) determined for T. gondii was ten times lower than EC 50 for HeLa cells [75]. In other studies, two Eurycoma longifolia fractions [76], Dictamnus dasycarpus extract [77] as well as oleuropein isolated from Fraxinus rhynchopchylla [78] revealed significant anti-Toxoplasma activity. A Dictamnus dasycarpus extract exhibited even higher selectivity than recommended and widely used anti-toxoplasmic medicine, sulfadiazine.…”

Section: Compounds Of Natural Originmentioning

confidence: 81%