Anti-TPO Antibodies Diffusion through the Placental Barrier during Pregnancy

Séror, J; Amand, Gaëlle; Gadrey, Jean; Ceccaldi, Pierre-François; Luton, Dominique

doi:10.1371/journal.pone.0084647

Cited by 47 publications

(33 citation statements)

References 26 publications

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“…In a recent paper, we demonstrated that TSH levels in cord blood at delivery were correlated with FT4 levels in the mother during the third trimester [5]. In view of our present findings, this is probably also the case during foetal life.…”

Section: Discussionsupporting

confidence: 79%

Foetal Thyroid Dysfunction: Treat the Mother First!

Khater¹,

Ceccaldi²,

Poujade³

et al. 2015

Horm Res Paediatr

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A case is presented of foetal compensated hypothyroidism due to persisting low maternal serum FT4 at the beginning of pregnancy. Diagnosis was made by means of foetal ultrasound followed by foetal blood sampling because of atypical findings. Foetal thyroid hypertrophy resolved progressively as exogenous thyroxine was administered to the mother. This case highlights once again the importance of adequate thyroid function during pregnancy.

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Section: Discussionsupporting

confidence: 79%

Foetal Thyroid Dysfunction: Treat the Mother First!

Khater¹,

Ceccaldi²,

Poujade³

et al. 2015

Horm Res Paediatr

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“…Secondly, subclinical hypothyroidism is often accompanied by increased concentrations of anti-thyroid antibodies (e.g. thyroid peroxidase antibodies, TPOAb), which, during pregnancy, are known to pass freely across the placenta into the fetal compartment (Radetti et al, 1999; Seror et al, 2014), and then, consequently, may impair fetal thyroid function and the concentration of circulating THs in the fetal compartment. Most but not all studies indicate that moderate or subclinical hypothyroidism exerts an adverse effect on child brain and cognitive development and increased risk for neurodevelopmental disorders (for review see Moog et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Childhood maltreatment is associated with increased risk of subclinical hypothyroidism in pregnancy

Moog

Heim

Entringer

et al. 2017

Psychoneuroendocrinology

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The critical importance of thyroid hormones for fetal development is well established. The developing fetus is dependent on the mother for adequate thyroid hormone supply, and maternal thyroid dysfunction in pregnancy may result in suboptimal fetal development. Because exposure to childhood maltreatment (CM) has been associated with thyroid dysfunction in the non-pregnant state, we sought to test the hypothesis that exposure to CM may represent a risk factor for the development of maternal hypothyroidism in pregnancy. The study was conducted in a healthy cohort of 102 pregnant mothers who were followed across the entire course of pregnancy. At each trimester thyroid-stimulating hormone (TSH) and free thyroxine (fT4) were measured in maternal serum. Experience of CM was assessed using the Childhood Trauma Questionnaire. After adjusting for potentially confounding variables, CM exposure was associated with increased TSH concentrations across pregnancy (F1,94.6=11.52, p=.001) and with a 4- to 7-fold increased risk of TSH levels above the trimester-specific clinical cut-off values. Women with clinically elevated TSH concentrations did not differ in fT4 concentrations from women with normal TSH concentrations (p > .1), suggesting subclinical hypothyroidism. Our findings suggest that there is a substantial and clinically relevant increased risk for thyroid dysfunction during pregnancy among women exposed to abuse or neglect in their childhood. This could potentially have adverse consequences for fetal brain development. Thus, these findings highlight the critical importance of considering CM exposure as a potential risk factor for (subclinical) hypothyroidism in pregnancy.

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“…Zwykle wykrywana jest w teście przesiewowym, bowiem u dziecka stwierdza się wysokie stężenie TSH oraz niskie stężenie fT4 [11,15,16]. Szybkie włączenie substytucji LT4 u tych dzieci zapewnia ich prawidłowy rozwój psychomotoryczny.…”

Section: Wstępunclassified

Hashimoto thyroiditis in mother and thyroid function in offspring – a prospective study

Zubkiewicz‐Kucharska¹,

Chrzanowska²,

Noczyńska³

2015

Pediatr. Endocrinol.

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Autoimmune thyroid disease (AITD) is diagnosed in 5-20% of pregnant women. Autoimmune thyroid disease in mother may be a cause of thyroid dysfunction in child. Hypothyroidism induced by thyrotropin receptor blocking antibodies (TRBAb) is present in 1-2% of children with congenital hypothyroidism. The aim of this paper was to evaluate thyroid function and presence of antithyroid antibodies in children of mothers with Hashimoto thyroiditis in the first year of life. Material and methods. 367 children were included into the study (185 boys, 182 girls, two twin pregnancies) of mothers with Hashimoto thyroiditis. The first visit in endocrinology out-patient clinic was done in 1 st -2 nd month of life, the follow-up visit at 6 th -9 th month of life. Anthropometrics were taken as well as blood samples for TSH, fT3, fT4, ATPO and ATG. Mothers had all proper thyroid function during the whole pregnancy. Results. 339 children (92,4%) were born on term, 281 (76,6%) with normal vaginal delivery, in good condition and with proper body mass. In three patients trisomy 21 was diagnosed. The neurological development of all children was not concerning. Thyroid function was proper (mean TSH 5,41±0,90 μIU/ml, fT3 8,00±1,24 pg/ml, fT4 16,89±2,09 pmol/l). None of the observed child had elevated titer of antithyroid antibodies. Conclusions. 1. Malfunction of the thyroid gland in children of mothers with Hashimoto thyroiditis is rare, therefore no further diagnostic procedures except screening test is required. 2. In preterm babies as well as in children presenting chaSłowa kluczowe choroba Hashimoto, autoimmunizacyjna choroba tarczycy, wrodzona niedoczynność tarczycy StreszczenieAutoimmunizacyjną chorobę tarczycy (AITD, autoimmune thyroid disease) rozpoznaje się u 5-20% ciężarnych. AITD u matki może być przyczyną dysfunkcji tarczycy u dziecka. Niedoczynność tarczycy wywołana przez przeciwciała blokujące receptor TSH (TRBAb, thyrotropin receptor blocking antibodies) występuje u 1-2% dzieci z wrodzoną niedoczynnością tarczycy. Celem pracy była ocena funkcji tarczycy oraz obecności przeciwciał przeciwtarczycowych u dzieci matek chorujących na przewlekłe limfocytarne zapalenie tarczycy typu Hashimoto w pierwszym roku ich życia. Materiał i metody. Badaniem objęto 367 dzieci (185 chłopców oraz 182 dziewczynki, dwie ciąże bliźniacze) urodzonych przez matki chorują-ce na chorobę Hashimoto. Odbyły się dwie wizyty w poradni endokrynologicznej: w 1-2 miesiącu życia i w 6-9 miesiącu życia. Wykonano pomiary antropometryczne oraz pobrano krew w celu oceny stężenia TSH, fT3, fT4, ATPO, ATG. Funkcja tarczycy u matek była wyrównana w czasie całej ciąży. Wyniki. 339 dzieci (92,4%) było urodzonych o czasie, 281 (76,6%) siłami natury, wszystkie w stanie dobrym i z prawidło-wą masą ciała. U trojga rozpoznano trisomię 21. Rozwój psychomotoryczny w czasie obserwacji nie budził niepokoju. Funkcja tarczycy u wszystkich dzieci była prawidłowa (średnie TSH 5,41±0,90 μIU/ml, fT3 8,00±1,24 pg/ml, fT4 16,89±2,09 pmol/l). U żadne-go dziecka nie stwierdzono ...

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Anti-TPO Antibodies Diffusion through the Placental Barrier during Pregnancy

Cited by 47 publications

References 26 publications

Foetal Thyroid Dysfunction: Treat the Mother First!

Foetal Thyroid Dysfunction: Treat the Mother First!

Childhood maltreatment is associated with increased risk of subclinical hypothyroidism in pregnancy

Hashimoto thyroiditis in mother and thyroid function in offspring – a prospective study

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