Anti-tuberculosis drugs adverse reactions: a review of the Iranian literature

Kargar, Mona; Mansouri, Ava; Hadjibabaie, Molouk; Javadi, Mohammadreza; Radfar, Mohammad Hadi; Gholami, Kheirollah

doi:10.1517/14740338.2014.925443

Cited by 11 publications

(7 citation statements)

References 28 publications

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“…Previous reports of some notable adverse drug reactions include weight increase and hepatotoxicity [29] , [45] , reproductive toxicity [29] , exanthema, hematological [46] among others when RIPE is used either as the sole agent or together. In fact, antituberculosis drug-induced hepatotoxicity has been reviewed [47] . According to WHO report on the Global project on antituberculous drug Resistance Surveillance, adverse effects of RIPE have chopped up into diminishing treatment effectiveness because they significantly contribute to treatment failure while relapse or the emergence of drug-resistance are now routinely encountered [48] .…”

Section: Discussionmentioning

confidence: 99%

The combined fixed-dose antituberculous drugs alter some reproductive functions with oxidative stress involvement in wistar rats

et al. 2016

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The reproductive toxicity of combined fixed-dose first-line antituberculosis (CFDAT) regimen was assessed in rats. Thirty-two (32) Wistar rats weighing 168.1 ± 8.0 g were divided into four groups of eight rats per group. Two groups of male and female rats were administered oral distilled water (1.6 ml) and CFDAT drugs containing rifampicin, isoniazid, pyrazinamide and ethambutol (RIPE, 92.5 mg/m2 per body surface area) respectively for forty-five days. Serum follicle stimulating hormone, luteinizing and testosterone were reduced significantly (p < 0.05) in the treated male rats. Similarly, sperm count levels were decreased by 27.3% when compared with control. RIPE elevated serum oestrogen (p < 0.05), progesterone (p < 0.05) as well as prolactin (p > 0.05) levels in the treated females. In addition, RIPE reduced (p < 0.05) total proteins levels and increased (p < 0.05, 53%) catalase levels in male but not female animals. Superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, reduced glutathione levels as well as lipid peroxidation were unaltered in all rats respectively. Histopathological studies revealed congested peritesticular vessels and no changes in the ovary when compared with control. Overall, our results demonstrate reproductive toxicity potentials of RIPE in the rat, thus, suggesting that these reproductive parameters be monitored during antituberculous chemotherapy.

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Section: Discussionmentioning

confidence: 99%

The combined fixed-dose antituberculous drugs alter some reproductive functions with oxidative stress involvement in wistar rats

et al. 2016

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“…These uncured patients are vulnerable to relapse and may even develop multi-drug resistant TB 1 3 . The lack of a uniform standard method for the determination of cured TB may also lead to over-treatments of some TB patients, causing the augmentation of drug-related mortality 4 . Moreover, chest X-rays and CT scans are subjective tests, and sputum smear cannot distinguish dead from viable bacteria (sensitivity = 19.6%, specificity = 87.0%) 5 , and sputum cultures require 4 to 8 weeks of incubation time (sensitivity = 91.8%, specificity = 57.8%) 6 .…”

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confidence: 99%

Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis

Wang

Wei

Shi

et al. 2015

Sci Rep

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Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking. A total of 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) analysis (fold change >1.50 or <0.60, P < 0.05). We validated albumin (ALB), Rho GDP-dissociation inhibitor 2 (ARHGDIB), complement 3 (C3), ficolin-2 (FCN2), and apolipoprotein (a) (LPA) using the enzyme-linked immunosorbent assay (ELISA) method. Significantly increased ALB and LPA levels (P = 0.036 and P = 0.012, respectively) and significantly reduced ARHGDIB, C3, and FCN2 levels (P < 0.001, P = 0.035, and P = 0.018, respectively) were observed in cured TB patients compared with untreated TB patients. In addition, changes in ALB and FCN2 levels occurred after 2 months of treatment (P < 0.001 and P = 0.030, respectively). We established a cured TB model with 87.10% sensitivity, 79.49% specificity, and an area under the curve (AUC) of 0.876. The results indicated that ALB, ARHGDIB, C3, FCN2, and LPA levels might serve as potential biomarkers for cured TB. Our study provides experimental data for establishing objective indicators of cured TB and also proposes potential markers for evaluating the efficacy of anti-TB drugs.

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“…Hepatic injury was the most common adverse reaction caused by anti-tuberculosis drugs, as described in other publications [24]. The incidence reported in previous studies vary greatly, from 2 to 28% [27], possibly due to differences in the criteria used to evaluate liver dysfunction, population characteristics and treatment regimens. The rate of drug withdrawal due to liver damage in this study was 22.7%, similar to that reported previously [43].…”

Section: Discussionmentioning

confidence: 86%

“…Adverse reactions caused by anti-tuberculosis drugs are important factors affecting the success of standard therapy for tuberculosis. Previous studies have reported that the total incidence of adverse reactions caused by anti-tuberculosis drugs is 12.6% in China [24], 12.5% in Portugal [25], 17.1% in Korea [26], and 33.6% in Iran [27]. The apparent variation between studies may be related to differences in the incidence of tuberculosis, treatment strategies used or definitions of adverse reactions, as well as other factors.…”

Section: Discussionmentioning

confidence: 99%

APACHE-II score for anti-tuberculosis tolerance in critically ill patients: a retrospective study

et al. 2019

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BackgroundTo investigate the status of anti-tuberculosis treatment in critically ill patients, and to explore the value of APACHE-II score in guiding anti-tuberculosis treatment.MethodsThis analysis included critically ill patients with tuberculosis. The utility of APACHE-II score for predicting drug withdrawal was evaluated using receiver operating characteristic (ROC) curve analysis.ResultsAmong 320 patients enrolled (58 ± 22 years; 256 males), 147 (45.9%) had drugs withdrawn. The drug withdrawal group had higher APACHE-II score (median [interquartile range]: 21 [3–52] vs. 17 [4–42] points), higher CD4%, lower hemoglobin level, higher rates of chronic obstructive pulmonary disease (COPD) and chronic renal failure, and lower rate of extrapulmonary tuberculosis (P < 0.05). Logistic regression identified APACHE-II score > 18 (odds ratio [95% confidence interval]: 2.099 [1.321–3.334], P < 0.01), COPD (1.913 [1.028–3.561], P < 0.05) and hemoglobin level (0.987 [0.977–0.997], P < 0.05) as independent factors associated with drug withdrawal. At an optimal cutoff of 18.5, the sensitivity, specificity, positive predictive value and negative predictive value of APACHE-II score for predicting drug withdrawal was 59.2, 61.8, 56.9 and 64.1%, respectively.ConclusionsAPACHE-II score > 18 points might predict patient tolerance of anti-tuberculosis treatment.

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Anti-tuberculosis drugs adverse reactions: a review of the Iranian literature

Abstract: The pattern of ADRs in Iranian articles was found to be similar to many other studies in the present review. We suggest that future studies resolve the confounding factors in this area that are mentioned in this review.

Cited by 11 publications

References 28 publications

The combined fixed-dose antituberculous drugs alter some reproductive functions with oxidative stress involvement in wistar rats

The combined fixed-dose antituberculous drugs alter some reproductive functions with oxidative stress involvement in wistar rats

Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis

APACHE-II score for anti-tuberculosis tolerance in critically ill patients: a retrospective study

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