Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study

Al-Salahi, Omar Saeed Ali; Ji, Dan; Majid, Amin Malik Shah Abdul; Chan, Kit‐Lam; Abdullah, Wan Zaidah; Zaki, A. K.; Din, Shah Kamal Khan Jamal; Yusoff, Narazah Mohd; Majid, Aman Shah Abdul

doi:10.1371/journal.pone.0083818

Cited by 22 publications

(22 citation statements)

References 51 publications

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“…Their results showed a significant anti-proliferative and growth inhibition activity against K-562 cells treated with various fractions of Eurycoma longifolia. Potent cytotoxicity and anti-proliferative effects were observed after 48 h of treatment with IC 50 value of 1963 and 661 mg/mL, respectively [57]. In this study, authors have also observed a dose-and time-dependent cytotoxicity of K-562 cells at different concentrations of Eurycoma longifolia at various time points [57].…”

Section: Evidence-based Overview Of Anti-proliferative and Anticancersupporting

confidence: 53%

“…Potent cytotoxicity and anti-proliferative effects were observed after 48 h of treatment with IC 50 value of 1963 and 661 mg/mL, respectively [57]. In this study, authors have also observed a dose-and time-dependent cytotoxicity of K-562 cells at different concentrations of Eurycoma longifolia at various time points [57]. They further explored the anti-proliferative and cytotoxicity mechanisms of Eurycoma longifolia.…”

Section: Evidence-based Overview Of Anti-proliferative and Anticancermentioning

confidence: 58%

“…Methanolic extract of Eurycoma longifolia has also been investigated against human leukemia cells (K-562) [57]. In this study, a wide range of in vitro experiments were performed including cell viability, clonogenic assay, annexin V-FITC/PI assay, Hoechst 33342 staining, cell cycle, and RT 2 profiler TM PCR array.…”

Section: Evidence-based Overview Of Anti-proliferative and Anticancermentioning

confidence: 99%

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Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells

Thu

Hussain

Mohamed

et al. 2018

CDT

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Section: Evidence-based Overview Of Anti-proliferative and Anticancersupporting

confidence: 53%

Section: Evidence-based Overview Of Anti-proliferative and Anticancermentioning

confidence: 58%

Section: Evidence-based Overview Of Anti-proliferative and Anticancermentioning

confidence: 99%

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Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells

Thu

Hussain

Mohamed

et al. 2018

CDT

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“…E. longifolia , particularly its roots is traditionally used for improvement of general health and libido. E. longifolia roots have been reported to exhibit various pharmacological and biological activities such as antimicrobial [1-4], anti-diabetic [5], antimalarial [6, 7], aphrodisiac activities [8] and cytotoxicity against cancerous cells [9-11]. The chemical profiling of E. longifolia root extract indicates alkaloids and quassinoids derivatives as the major bioactive compounds found in this plant [12, 28].…”

Section: Introductionmentioning

confidence: 99%

LC-Based Metabolomics and Multivariate Analyses Reveal Metabolite Variations in Different Propagation Methods ofEurycoma longifoliaRoots Harvested at Different Ages and Locations

Alias

Azizan

Basherudin

et al. 2020

Preprint

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28Eurycoma longifolia is a well-known medicinal plant with pharmacological effects and 29 important bioactive compounds such as alkaloids and quassinoids. The suitable age of 30 harvesting E. longifolia root for commercial use is relatively unknown and could influence the 31 overall bioactive compounds present in the plant. In this study, non-targeted liquid 32 chromatography mass spectrometer (LC-MS) and multivariate analyses (MVA) were 33 performed to determine the chemical constituent of aqueous extract of 3-month-old E. 34 longifolia hairy root (HR) culture, 1-, 4-and 11-year-old harvested E. longifolia roots. 35 Unsupervised principle component analysis (PCA) and supervised partial least square 36 discriminant analysis (PLSDA) were applied to evaluate metabolic similarities and differences 37 in E. longifolia roots and hairy root in response to different harvesting age, locations and 38 propagation methods. A total of 34 significant buckets with variable importance in projection 39 (VIP) exceeding 1 were selected and identified. It was found that putatively identified 40 quassinoids were significantly higher in 1-, 4-and 11-year-old E. longifolia roots whereas 41 putative canthin-6-one alkaloids were abundantly present in 3-month-old E. longifolia hairy 42 root (HR). These findings may be applicable to improve the harvesting age and increase the 43 content of bioactive compounds in E. longifolia roots. 44 Introduction 54 Eurycoma longifolia Jack, locally known as Tongkat Ali, is an herbaceous tree of the family 55 Simaroubaceae, commonly found in Southeast Asian countries like Malaysia, Indonesia, 56 Thailand, Myanmar, Cambodia and Laos. E. longifolia, particularly its roots is traditionally 57 used for improvement of general health and libido. E. longifolia roots have been reported to 58 exhibit various pharmacological and biological activities such as antimicrobial [1-4], anti-59 diabetic [5], antimalarial [6, 7], aphrodisiac activities [8] and cytotoxicity against cancerous 60 cells [9-11]. The chemical profiling of E. longifolia root extract indicates alkaloids and 61 quassinoids derivatives as the major bioactive compounds found in this plant [12, 28]. 62 Quassinoids, particularly eurycomanone and their derivatives were reported to be abundant in 63 E. longifolia roots and responsible for various pharmacological properties. 64 The increasing demands of E. longifolia root as herbal medicinal products have been 65 impeded by the slow growth and late maturity of this plant. The suitable harvesting age of E. 66 longifolia roots is unclear, but for commercial use, E. longifolia roots are usually harvested at 67 the age of four years old [13]. Today, approximately 21,000 kg of E. longifolia were harvested 68 to meet a demand of more than 54,000 kg per year [12]. As a result, this practice has led to 69 excessive exploitation, extinction and adulterations in E. longifolia based products. Therefore, 70 there is a need to standardize harvesting age to ensure sufficient supply and sustainability of 71...

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“…The traditional uses or phytochemical properties of E longifolia from several literature reviews are antianxiety,[4546] antibacterial,[2529474849] anticancer,[35385051] antifungal,[28] anti-inflammation,[40415253] antimalarial,[54555657] antioxidant,[52] antiparasitic,[58] antiulcer,[59] ergogenic activities,[6061] and reproductive improvement. [626364656667]…”

Section: Introductionmentioning

confidence: 99%

Review ergogenic effect of long jack, Eurycoma Longifolia

Khanijo

Jiraungkoorskul

2016

Phcog Rev

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Eurycoma longifolia (family: Simaroubaceae) is commonly distributed in the Southeast Asia and Indo-China. In particular, the aqueous extract and decoction of its root are a well-known folk medicine which enhances sexuality, fertility, and antiaging. Furthermore, it has been shown to possess anti-inflammatory, antimalarial, antimicrobial, and antioxidant properties. Its common phytochemical components include alkaloids, flavonoids, phenolics, saponins, tannins, and triterpenes. This plant is rich in various quassinoids including eurycolactone, eurycomalactone, eurycomanol, eurycomanone, and eurycomaoside all of which has been reported to contribute to its remedial properties including increased muscle strength, endurance in cycling time, and reduced anxiety and stress. Based on established literature on the health benefits of E. longifolia, this review article has attempted to compile E. longifolia to be one of the choices of ergogenic plants.

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Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study

Cited by 22 publications

References 51 publications

Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells

Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells

LC-Based Metabolomics and Multivariate Analyses Reveal Metabolite Variations in Different Propagation Methods ofEurycoma longifoliaRoots Harvested at Different Ages and Locations

Review ergogenic effect of long jack, Eurycoma Longifolia

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