Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles

Targeted Nanoparticles for Cancer Therapy

“…Results showed the cytotoxicity and cellular uptake of PTX-loaded NPs against human cervical carcinoma (HeLa) cells for their tumor-targeting effects [135].…”

“…For instance, PTX-loaded NPs based on Herein, an hyperbranched amphiphilic poly[(amine-ester)-co-(D,L-lactide)]/1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer (HPAE-co-PLA/DPPE), which was modified with two targeting ligands, RGD and Tf were synthesized [135]. Thus, these dual-targeting NPs may achieve more accumulation and improved lethality of the PTXloaded NPs in tumors.…”

Dual-targeting delivery system for bone cancer: synthesis and preliminary biological evaluation

“…Chemotherapy is essential in the treatment of malignant tumors; however, its efficacy is usually limited due to the poor physiochemical properties, low stability, short circulating half-life, and the toxicity to normal tissues associated with the antitumor drugs (Xu et al, 2012).…”

“…Recently, dual-targeting delivery has been widely developed and played an important role in a variety of areas (Alpizar et al, 2011;Petkau et al, 2011;Yogev et al, 2011;Jackson et al, 2012), including cancer therapy (Shao et al, 2012;Xu et al, 2012). Which primary usually delivered anticancer drug to the diseased tissue, then to the tumors with some targeting moieties (Petkau et al, 2011).…”

“…In addition, the conjugate of paclitaxel (PTX) with cyclic RGD and transferrin conjugated nanoparticles also had dual-targeting function (Xu et al, 2012).…”