Anti-tumor effect of M2000 (β-
            <scp>d</scp>
            -mannuronic acid) on the expression of inflammatory molecules in the prostate cancer cell

Mohsenzadegan, Monireh; Moghbeli, Fatemeh; Mirshafiey, Abbas; Farajollahi, Mohammad M

doi:10.1080/08923973.2021.1931301

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Treated cells with high concentration of mannuronic acid showed lower gene expression of COX-2 and IL-8 and decreased expression of the MMP-9 gene was observed at both doses. These authors concluded that mannuronic acid in both high and low concentrations are able to down-regulate the inflammatory molecules in the PCa cells [66].…”

Section: Anti-cancer Effect Of Mannuronic Acid and Its Molecular Mech...mentioning

confidence: 98%

An Insight into the Health Benefits of Sodium Alginate and its Derivatives

Mirshafiey

2024

BJSTR

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Owing to safety and unique properties, alginates are widely used in Biomedicine, food industry and pharmaceutics products. The multifaceted properties of alginate make it a captivating topic for extra scientific exploration in the anti-inflammatory and anti-tumoral areas. This paper describes the biological properties including anti-cancer and anti-inflammatory functions of sodium alginate and its components, mannuronic acid and guluronic acid, as alginate derivatives. However, the wide application of alginates as polysaccharides is limited due to their high molecular weight and low solubility; therefore, its degraded monomers, mannuronic acid and guluronic acid as products of alginate hydrolysate can be a solution in this case. In conclusion, these natural non-toxic, biocompatible, biodegradable, and quite cost-effective materials are totally operative for cancer management and control of inflammation, as their important biological effects and health benefits, in addition to their wide applications in food industry.

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Section: Anti-cancer Effect Of Mannuronic Acid and Its Molecular Mech...mentioning

confidence: 98%

An Insight into the Health Benefits of Sodium Alginate and its Derivatives

Mirshafiey

2024

BJSTR

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“…Study on the effect of Mannuronic acid on PC3 cells explained that it had no cytotoxicity effect on this cell line at the concentration of ≤200 μg/ml. Additionally, Mannuronic acid could reduce the gene expression of inflammatory molecules in prostate cancer cells, including MYD-88, NF-kB, IL-8, MMP-9, and COX-2 [41].In a rat model study related to Alzheimer's disease was shown that Mannuronic acid has the potential to change the behavior of these rats, which causes a significant halt in amyloid plaque production pathway. In addition, the amount of Bax/Bcl2, P53, MDA, SOD, and procaspase-3 were normalized in treated experimental rats [42].…”

Section: Toxicology Assessment Of Mannuronic Acidmentioning

confidence: 99%

"Safety Assessment for Mannuronic and Guluronic Acids, as Alginate Residues in Toxicology Studies"

Mirshafiey

2023

BJSTR

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Objective: The present study aims to search the safety assessment for Mannuronic and Guluronic acids as Alginate residues in toxicology examinations. Concerning the fact that Alginate is a safe agent and is vastly used in the food industry, many investigations were conducted to evaluate the safety property of Mannuronic(M) and Guluronic (G) acids as the natural uronic acids and Alginate residues.Material and Method: In the major studies, for the acute toxicity assessment, the BALB/c mice and Wistar rats received orally five different single doses of (M) in one study and (G) in another study and were then kept under observation for 14 days. In the chronic study, the animals were divided into four groups and treated orally once daily with (M) and/or (G) at dose levels of 0, 50, 250, and 1250 mg/kg body weight for at least 63 and 90 days. The mortality, clinical signs, biochemical and hematological parameters, body weight changes, gross findings, organ weights, and histopathological determinations were monitored during this evaluation. In the minor studies, the safety property of (M) and (G) was assessed indirectly using in vitro and in vivo examinations. Results:In these studies, the results of acute toxicity revealed that the LD50 for Mannuronic and Guluronic acids are 4600 and 4800 mg/kg, respectively. The findings of these investigations showed no mortality, morbidity, or abnormality in the chronic study of any animal's body weight, organ weight, or necropsy. Moreover, the accumulated data showed no significant difference in these animals' biochemical, hematological, and histopathological determinants. Conclusions:The results of toxicology studies show that Mannuronic acid and Guluronic acid have high safety when administered orally in animals.

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“…However, some studies have shown that the oligosaccharide products obtained from sodium alginate degradation have excellent biological and pharmacological activities. Polymannuronic acid (PM) (nonsulfated polysaccharide, Figure 1 ), an active fragment of sodium alginate, possesses more pharmacological activities than sodium alginate itself, including anti-tumor [ 4 ], antioxidant [ 5 ], anticoagulation [ 6 ], immune regulation [ 7 ], anti-inflammatory [ 8 ], neuroprotection [ 9 ], and hypolipidemic [ 10 ], and other properties [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Labeling of Polymannuronic Acid and Its Distribution in Mice by Tail Vein Injection

et al. 2022

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Polymannuronic acid (PM) possesses more pharmacological activities than sodium alginate, but there have been few studies on its absorption mechanism, tissue distribution, and pharmacokinetics. Studies of pharmacokinetics and tissue distribution are necessary to elucidate the pharmacological effects of PM. Thus, we used fluorescein isothiocyanate (FITC) to produce fluorescently labeled PM (FITC-PM) and detected the distribution and pharmacokinetics of PM in vivo via tail vein injection. The results demonstrate that the FITC-PM showed high stability in different pH solutions. After the tail vein injection, FITC-PM tended to be distributed in the kidney, followed by the liver and in the heart, spleen, and lungs at lower concentrations. Pharmacokinetic analysis showed that the elimination rate constant of FITC-PM was 0.24, the half-life time was 2.85 h, the peak concentration was 235.17 μg/mL, the area under the curve was 631.48 μg/mL·h, the area under the curve by statistical moment was 1843.15 μg/mL·h2, the mean residence time was 2.92 h, and the clearance rate was 79.18 mL/h. These results indicate that FITC-PM could be used for PM distribution and pharmacokinetic studies, and the studies of pharmacokinetics and tissue distribution provided basic information that can be used to further clarify PM pharmacodynamic mechanisms.

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Anti-tumor effect of M2000 (β- d -mannuronic acid) on the expression of inflammatory molecules in the prostate cancer cell

Cited by 5 publications

References 31 publications

An Insight into the Health Benefits of Sodium Alginate and its Derivatives

An Insight into the Health Benefits of Sodium Alginate and its Derivatives

"Safety Assessment for Mannuronic and Guluronic Acids, as Alginate Residues in Toxicology Studies"

Fluorescent Labeling of Polymannuronic Acid and Its Distribution in Mice by Tail Vein Injection

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