Anti-Tumor Effect of Vitamin D Combined with Calcium on Lung Cancer: A Systematic Review and Meta-Analysis

Sun, Kang; Zuo, Minghao; Zhang, Qin; Wang, Keyi; Huang, Dongdong; Zhang, Honghe

doi:10.1080/01635581.2020.1850812

Cited by 10 publications

(21 citation statements)

References 61 publications

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“…The association between serum/plasma 25(OH)D concentration and NMSC risk is most likely due to UV radiation exposure being causally linked to both vitamin D concentration in the blood and NMSC risk. The mild, yet significantly increased BCC risk observed among individuals with higher vitamin D intake in the large study by Park et al is difficult to explain, particularly in light of the growing evidence in favour of a protective effect played by vitamin D supplementation against cancer at several body sites [ 34 , 35 , 36 ]. However, the finding by Park et al was mild, limited to BCC, and not confirmed in any other study, including two vitamin D supplementation RCTs which, because of their experimental design, are expected to be less susceptible to biases (e.g., confounding and misclassification) affecting observational studies.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup

Caini¹,

Gnagnarella

Stanganelli

et al. 2021

Cancers

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We aimed to provide a comprehensive overview of the link between vitamin D and non-melanoma skin cancer (NMSC). For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet and supplements) and blood concentration, polymorphisms of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes, and the risk of NMSC. Random effects meta-analysis models were fitted to merge study-specific risk estimates into summary relative risk (SRR) and corresponding 95% confidence intervals (CI). Twenty-four studies altogether were included. There was a suggestive association between increasing serum/plasma vitamin D concentration and NMSC risk (SRR for highest vs. lowest concentration 1.67, 95%CI 0.61–4.56), although with large heterogeneity across studies (I2 = 91%). NMSC risk was associated with highest vitamin D intake in observational studies but not in clinical trials. Finally, there was no significant association between any polymorphism of the VDR and VDBP genes and NMSC risk. In conclusion, no strong relationship between vitamin D metabolism and NMSC risk appears to exist according to our systematic review and meta-analysis, although some findings are worthy of further investigation.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup

Caini¹,

Gnagnarella

Stanganelli

et al. 2021

Cancers

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“…The full texts of 49 papers were evaluated in detail, including 41 articles in the main search and eight articles in the citation search. After all reviews, 59 reports from 35 papers [12][13][14][18][19][20][21][22][23][24] that ultimately met the inclusion criteria were included in the meta-metaanalysis. The included (Table S6) and excluded meta-analyses and the reasons for excluding the removed studies are summarized in Supp.…”

Section: Search Resultsmentioning

confidence: 99%

“…[12,14,21]. Additionally, high Vit-D intake or high serum 25(OH)D levels were associated with a lower risk of liver cancer [13], ovarian cancer [22], and lung cancer [23,24].…”

Section: Introductionmentioning

confidence: 99%

<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

Arayıcı¹,

Başbınar²,

Ellıdokuz³

2023

Preprint

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It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose of this paper was to elucidate the effects of Vit-D intake and serum 25-hydroxyvitamin-D (25(OH)D) levels on cancer incidence and mortality, the current evidence in this field, and the biases of this evidence using the meta-meta-analysis method. Meta-analyses focusing on Vit-D intake, serum 25(OH)D levels, and cancer risk/mortality were identified. A structured computer literature search was performed in PubMed/Medline, Web of Science (WoS), and Scopus electronic databases using predetermined keyword combinations. Primary and secondary meta-meta-analyses were carried out, combining odds ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) for outcomes reported in selected meta-analyses. A total of 35 eligible meta-analyses assessing the association between Vit-D and cancer incidence and/or mortality were included in this study. In the pooled analysis, higher Vit-D intake and serum 25(OH)D levels were associated with lower cancer risk (OR = 0.93, 95% CI: 0.90-0.96, p < 0.001; OR = 0.80, 95% CI: 0.72-0.89, p < 0.001, respectively) and cancer-related mortality (RR = 0.89, 95% CI: 0.86-0.93, p < 0.001; RR = 0.67, 95% CI: 0.58-0.78, p < 0.001, respectively). When meta-analyses whose primary reports included only randomized controlled trials were pooled, there was no significant association between Vit-D intake and cancer risk (OR = 0.99, 95% CI: 0.97-1.01, p = 0.320). In subgroup analysis, Vit-D consumption was associated with a significant decrease in colorectal and lung cancer incidence (OR = 0.89, 95% CI: 0.83-0.96, p = 0.002; OR = 0.88, 95% CI: 0.83-0.94, p < 0.001, respectively). Taken together, both Vit-D intake and higher 25(OH)D levels may provide remarkable benefits in terms of cancer incidence and mortality, however, careful evaluation according to cancer types is critically important and recommended.

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“…A meta-analysis by Yang et al [ 19 ] combined the results of 32 studies and found no statistical correlation between dairy or calcium intake and LC risk. Nevertheless, the latest large meta-analysis [ 60 ] by Sun et al found that calcium supplementation alone was not significantly associated with the risk of LC. However, calcium and vitamin D supplementation significantly reduced the incidence of LC, suggesting that calcium and vitamin D may synergistically affect tumor inhibition.…”

Section: Discussionmentioning

confidence: 99%

Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study

et al. 2022

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Previous observational studies have suggested that the effect of diet-derived circulating micronutrient concentrations on lung cancer (LC) risk is controversial. We conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between circulating micronutrient concentrations and the overall risk of LC and three LC subtypes (namely lung adenocarcinoma (LA), squamous cell lung cancer (SqCLC), and small cell lung cancer (SCLC)). The instrumental variables (IVs) of 11 micronutrients (beta-carotene, calcium, copper, folate, lycopene, magnesium, phosphorus, retinol, selenium, zinc, and vitamin B6) were screened from the published genome-wide association studies (GWAS). Summary statistics related to LC and its subtypes came from the largest meta-analysis, including 29,266 cases and 56,450 controls. Inverse-variance weighted (IVW) method is used as the main MR analysis, and the sensitivity analysis is carried out to ensure the MR assumptions. This MR study found suggestive evidence that genetically predicted 6 circulating micronutrient concentrations was correlated with the risk of overall LC (odds ratio (OR): 1.394, 95% confidence interval (CI): 1.041–1.868, p = 0.026, phosphorus), LA (OR: 0.794, 95% CI: 0.634–0.995, p = 0.045, beta-carotene; OR: 0.687, 95%CI: 0.494–0.957, p = 0.026, calcium), SqCLC (OR: 0.354, 95% CI: 0.145–0.865, p = 0.023, retinol), and SCLC (OR: 1.267, 95% CI: 1.040–1.543, p = 0.019, copper; OR: 0.801, 95% CI: 0.679–0.944, p = 0.008, zinc). We found no evidence that other micronutrients are associated with the risk of overall LC or its subtypes. Our study suggested that the increase in circulating beta-carotene, calcium, retinol, and zinc concentration may reduce the risk of LC; the increase in circulating copper and phosphorus concentration may be related to the increased risk of LC. In the future, larger replication samples of LC genetic data and larger micronutrient-related GWAS will be needed to verify our findings.

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Anti-Tumor Effect of Vitamin D Combined with Calcium on Lung Cancer: A Systematic Review and Meta-Analysis

Cited by 10 publications

References 61 publications

Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup

Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup

<strong>Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies</strong>

Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study

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