Anti-tumor immune potentiation targets-engineered nanobiotechnologies: Design principles and applications

Jiao, Rong; Lin, Xia; Zhang, Qian; Zhang, Yan; Qin, Wen; Yang, Qiaoling; Xu, Chuan; Chen, Fubo; Zhang, Kun

doi:10.1016/j.pmatsci.2023.101230

Cited by 16 publications

(2 citation statements)

References 295 publications

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“…Nanoscale materials have attracted much attention and research in various fields recently. − Due to the small radius of neovascularization in diabetic microangiopathy, nanoscale UCAs have obtained significant attention. The newly developed nanosized UCA would have superior advantage in early quantitative diagnosis of diabetic microvasculature complications in the future …”

Section: Discussionmentioning

confidence: 99%

Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges

Liu,

Wang,

Qiu

et al. 2024

ACS Appl. Bio Mater.

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Diabetes vasculopathy is a significant complication of diabetes mellitus (DM), and early identification and timely intervention can effectively slow the progression. Accumulating studies have shown that diabetes causes vascular complications directly or indirectly through a variety of mechanisms. Direct imaging of the endothelial molecular changes not only identifies the early stage of diabetes vasculopathy but also sheds light on the precise treatment. Targeted ultrasound contrast agent (UCA)-based ultrasound molecular imaging (UMI) can noninvasively detect the expression status of molecular biomarkers overexpressed in the vasculature, thereby being a potential strategy for the diagnosis and treatment response evaluation of DM. Amounts of efforts have been focused on identification of the molecular targets expressed in the vasculature, manufacturing strategies of the targeted UCA, and the clinical translation for the diagnosis and evaluation of therapeutic efficacy in both micro-and macrovasculopathy in DM. This review summarizes the latest research progress on endothelium-targeted UCA and discusses their promising future and challenges in diabetes vasculopathy theranostics.

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Section: Discussionmentioning

confidence: 99%

Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges

Liu,

Wang,

Qiu

et al. 2024

ACS Appl. Bio Mater.

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“…23,24 Nevertheless, its main drawback lies in its inadequate sensitivity. 25 Near-infrared fluorescence imaging (NIR) has emerged as a prevalent technique for assessing pathophysiological microenvironments, owing to its noninvasive detection, easy operation, and real-time monitoring capabilities, 26–29 whereas albeit with the disadvantage of limited penetration depth, while this limitation can be mitigated by integrating with US molecular imaging, thereby effectively compensating for the restricted penetration depth. Hence, the incorporation of NIR with US molecular imaging through the development of a US/NIR multimodal molecular probe can provide facilitating rapid, high-resolution imaging with a deep penetration depth, therefore enabling the effectively evaluation of myocardial fibrosis.…”

Section: Introductionmentioning

confidence: 99%

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis

Zhao,

Qin,

Wang

et al. 2024

Nanoscale Adv.

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Tumor Microenvironment‐Selective Sol–Gel Mineralization of ROS‐Responsive Stretchable and Conductive Hydrogel

Robby,

Yang,

Jin

et al. 2024

Adv Funct Materials

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Cancer cell‐triggered sol–gel transformation of mineralized hydrogel (PAA‐MnO2) is designed as a facile strategy for cancer detection by manipulating the mineralization process in the presence of cancer cells. The mineralization of polyacrylic acid (PAA) with calcium phosphate via carboxyl‐Ca2+ complex is initially inhibited by the incorporation of reactive oxygen species (ROS)‐sensitive manganese oxide (MnO2) with polymer dots (PDs). In this system, the mineralization can be induced after cleaving MnO2 into Mn2+ by high ROS levels in cancer cells, forming a PAA‐MnO2 mineralized hydrogel and resulting in a naked‐eye system for cancer monitoring. Naked‐eye monitoring of ROS‐responsive sol–gel transformation is performed using a circulator device containing circulating cells to discriminate cancer (HeLa, PC‐3, B16F10) from normal cells (CHO‐K1). With the incorporation of PDs, PAA‐MnO2 mineralized hydrogel not only provides physical transformation (stretchability, viscosity) but also fluorescence‐recovery and electroconductivity changes at different cancer‐cell concentrations (104–106 cells mL−1), including distinct strain–pressure responses that can be wirelessly monitored via smartphones. Furthermore, in vivo, experiments suggest that PAA‐MnO2 mineralized hydrogel can be formed in tumor‐bearing mice owing to its excellent ROS‐scavenging activity at the tumor site, as confirmed by SOD2 and gene‐expression analysis. Thus, this unique approach can potentially enable simple and effective cancer detection in future point‐of‐care diagnostics.

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Anti-tumor immune potentiation targets-engineered nanobiotechnologies: Design principles and applications

Cited by 16 publications

References 295 publications

Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges

Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis

Tumor Microenvironment‐Selective Sol–Gel Mineralization of ROS‐Responsive Stretchable and Conductive Hydrogel

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