Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery

Ivanovska, Iva; Muhoro, Clare N.; Irusta, Pablo M.

doi:10.2174/138955706778195216

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…Apoptosis is a result of cell cycle arrest and its rate may be used to predict the cytotoxicity of anti-cancer agents (36,37). In the presence of pro-death stimuli, including cytotoxic agents, cells respond by initiating programmed death, characterized by certain detectable morphological alterations, including nuclear fragmentation, chromatin condensation, cell shrinkage, membrane blebbing and formation of apoptotic bodies (26,38). The aforementioned morphological alterations serve as indicators of cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells

Zhang

Chen

et al. 2018

Mol Med Report

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Glioblastoma is a common primary brain tumor with aggressive malignancy, which results in poor outcomes, short survival time and high mortality. Vitexin, an active ingredient from natural products, has been reported to inhibit cell growth and induce cell apoptosis in various cancer cell lines including hepatocellular carcinoma, oral and esophageal cancer. To the best of the authors knowledge, the present study was the first to investigate anticancer effects of vitexin on human glioblastoma cells and potential underlying mechanisms. The present study demonstrated that vitexin inhibited cell viability in a dose‑ and time‑dependent manner. In the present study, vitexin induced G2/M cell cycle arrest, as demonstrated by flow cytometry. Induction of cell apoptosis following vitexin treatment, was further indicated by observation of morphological alterations, flow cytometry analysis and detection of cleaved‑poly (ADP‑ribose) polymerase. The present study also demonstrated that vitexin inhibited RAC‑alpha serine/threonine‑protein kinase (Akt)/mechanistic target of rapamycin kinase (mTOR) signaling in human glioblastoma cells. Collectively, the results of the present study demonstrated that vitexin induced G2/M cell cycle arrest and apoptosis by inhibiting Akt/mTOR signaling in human glioblastoma cells. Vitexin may in the future be used as a therapeutic agent for treatment of malignant glioblastoma.

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Section: Discussionmentioning

confidence: 99%

Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells

Zhang

Chen

et al. 2018

Mol Med Report

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“…It is generally assumed that tumor suppression is at least in part due to p53induced apoptosis and that, during tumor formation, a selection for p53 loss of function takes place [3]. These anti-apoptotic proteins are often over-expressed as a result of chromosomal translocations in various tumors, for instance, leukemia, lymphoma, and breast cancer [6,7]. Contrarily, the anti-apoptotic protein Bcl-2 and some Bcl-2-related proteins such as Bcl-X L are *Address correspondence to this author at Biological Chemistry, Leiden University; Einsteinweg 55, 2333 CC Leiden, The Netherlands.…”

Section: Imbalance Of Rescue and Apoptosismentioning

confidence: 99%

Viral Elements Sense Tumorigenic Processes:Approaching Selective Cancer Therapy

Kooistra

Zhang²,

Noteborn³

2007

MRMC

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Viruses can produce viral oncoproteins that drive multiple genetic alterations as the consequence of neoplastic transformation. Viral proteins encoded by onco-related viruses such as polyomavirus SV40 or Epstein-Barr virus are involved in cellular processes resulting in imbalance between proliferation and cell death, knowledge of which continues to be crucial for combating cancer. On the other hand, viruses also generate viral components that, from a cold viral protein, can become a tumor-selective killer by sensing cellular tumorigenic hallmarks. For instance, the avian virus derived apoptin protein has been proven to induce tumor-regression in various pre-clinical animal models without showing detectable side effects. In particular, apoptin-interacting protein partners such as components of the anaphase promoting complex were identified as potential anticancer drug targets. The adenovirus-derived protein E4orf4, another viral protein with tumor-specific apoptosis characteristics, has been proven to interact with the tumor-suppressor protein phosphatase 2A. This review aims to describe recent studies with representative viral elements that have contributed to our understanding of critical tumorigenic processes and have conferred an impact on the development of novel anti-cancer therapies.

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Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery

Cited by 2 publications

References 61 publications

Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells

Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells

Viral Elements Sense Tumorigenic Processes:Approaching Selective Cancer Therapy

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