Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells

Pagnan, Ana Lígia; Pessôa, Adriano de Souza; Tokuhara, Cíntia Kazuko; Fakhoury, Vanessa Svizzero; Oliveira, Gabriela Silva Neubern de; Sanches, Mariana Liessa Rovis; Inacio, Kelly Karina; Ximenes, Valdecir Farias; Oliveira, Rodrigo Cardoso de

doi:10.1016/j.tice.2021.101705

Cited by 9 publications

(6 citation statements)

References 35 publications

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“…CA phenethyl ester showed greater selectivity towards tumor cells, thus protecting normal cells. These results illustrate the potential anticancer properties of CA phenethyl ester, and they highlight ways in which incorporating a phenethyl ester could lead to improved drug performance over its CA predecessor [ 40 ].…”

Section: Dietary Phenolic Compounds As Anticancer Drugs: Targeted Mec...mentioning

confidence: 94%

“…To find new treatments for osteosarcoma, Pagnan et al explored the anticancer effect of CA phenethyl ester, and its precursor CA, on murine osteosarcoma UMR-106. CA phenethyl ester (IC 25 = 1.3 μM/IC 50 = 2.7 μM) was found to diminish mitochondrial ROS production, cell migration, and cell viability when compared with CA alone (IC 25 = 91.0 μM/IC 50 = 120.0 μM) [ 40 ]. CA phenethyl ester showed greater selectivity towards tumor cells, thus protecting normal cells.…”

Section: Dietary Phenolic Compounds As Anticancer Drugs: Targeted Mec...mentioning

confidence: 99%

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Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Bakrim

Omari

Bakri

et al. 2022

Foods

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Given the stochastic complexity of cancer diseases, the development of chemotherapeutic drugs is almost limited by problems of selectivity and side effects. Furthermore, an increasing number of protective approaches have been recently considered as the main way to limit these pathologies. Natural bioactive compounds, and particularly dietary phenolic compounds, showed major protective and therapeutic effects against different types of human cancers. Indeed, phenolic substances have functional groups that allow them to exert several anti-cancer mechanisms, such as the induction of apoptosis, autophagy, cell cycle arrest at different stages, and the inhibition of telomerase. In addition, in vivo studies show that these phenolic compounds also have anti-angiogenic effects via the inhibition of invasion and angiogenesis. Moreover, clinical studies have already highlighted certain phenolic compounds producing clinical effects alone, or in combination with drugs used in chemotherapy. In the present work, we present a major advance in research concerning the mechanisms of action of the different phenolic compounds that are contained in food medicinal plants, as well as evidence from the clinical trials that focus on them.

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Section: Dietary Phenolic Compounds As Anticancer Drugs: Targeted Mec...mentioning

confidence: 94%

Section: Dietary Phenolic Compounds As Anticancer Drugs: Targeted Mec...mentioning

confidence: 99%

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Bakrim

Omari

Bakri

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…Furthermore, phenols are able to optimize the tumor microenvironment via eliminating ROS [ 154 ]. Ana Lígia Pagnan et al found that caffeic acid and caffeic acid phenethyl ester functioned of scavenging endogenous ROS, effectively restrained the cell proliferation and angiogenesis in tumors [ 155 ]. Moreover, the epithelial-mesenchymal transition (EMT) is a key pre-process that enables tumor cells to migrate and invade.…”

Section: Phenols Ameliorate the Microenvironment Of Bone Regenerationmentioning

confidence: 99%

Plant molecules reinforce bone repair: Novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects

Chen,

Gan,

Cheng

et al. 2024

Materials Today Bio

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“…In another study, CAPE was found to be more effective than its derivative, caffeic acid (CA), in reducing the viability of osteosarcoma cells (UMR‐106) and reducing cell migration. Moreover, CAPE has been shown to exhibit 44‐fold higher toxicity than CA for half‐maximum inhibitory concentration calculated after 72 h of treatment (Pagnan et al, 2022). In addition, the efficacy of CAPE for head and neck squamous carcinoma was 2 times higher than CA (Dziedzic, Kubina, Kabala‐Dzik, & Tanasiewicz, 2017), the same trend was found using triple‐negative breast adenocarcinoma cells (MDA‐MB‐231) (Kabala‐Dzik et al, 2017) and breast cancer cells (MCF‐7) (Kabala‐Dzik et al, 2018).…”

Section: Cape As Anticancermentioning

confidence: 99%

Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy

Taysı

Algburi

Taysi

et al. 2022

Phytotherapy Research

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Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti‐proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID‐19).

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Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells

Cited by 9 publications

References 35 publications

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Plant molecules reinforce bone repair: Novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects

Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy

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