Anti-ulcer Activity of Ethanol Root Extracts of Cassia sieberiana D.C. in Albino Rats

Bello, H.; Mohammed, Z.; Katsayal, UA

doi:10.9734/ejmp/2016/22655

Cited by 5 publications

(4 citation statements)

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“…The pharmacological activity (analgesic and anti-inflammatory) of the C. siebieriana used in the preparation of NPK 500 were evaluated in animal model using the acetic acid induced and carrageenan-induced oedema models. Aqueous extract from the root of C. siebieriana showed comparable analgesic and anti-inflammatory activity relative to the acetylsalicylic acid standard [ 240 ]. A study conducted on the anti-ulcer potential of the C. siebieriana produced significant and dose dependent anti-ulcer activity [ 240 ].…”

Section: Resultsmentioning

confidence: 99%

“…Aqueous extract from the root of C. siebieriana showed comparable analgesic and anti-inflammatory activity relative to the acetylsalicylic acid standard [ 240 ]. A study conducted on the anti-ulcer potential of the C. siebieriana produced significant and dose dependent anti-ulcer activity [ 240 ]. In another anti-ulcer study in rat model, the extract remarkably prevented the ethanol induced reduction in function levels of some enzymes like superoxide dismutase, catalase and glutathione peroxidase.…”

Section: Resultsmentioning

confidence: 99%

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A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Kumadoh

Archer

Yeboah

et al. 2021

Heliyon

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Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and invitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Kumadoh

Archer

Yeboah

et al. 2021

Heliyon

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“…They are potential sources in the discovery and development of new therapeutic agents (Blunt et al, 2018). Ethnobotanical claims show some plants that have been used as antiulcer; these include bulbs of Allium sativum, root extracts of Cassia sieberiana, stem bark extract of Anogiesuss leiocarpus, seedpods of Acacia nolitica (Bello et al, 2016, Datok et al, 2022, Abdulazeez & Balogun, 2023. The plant investigated in this study is Anogeissus leiocarpus belongs to the family Combretaceae and is widely distributed in Central, East, and West African countries.…”

Section: Introductionmentioning

confidence: 99%

Preliminary physicochemical evaluation of effervescent granules of Anogiessius leocarpus stem bark extract

Olayemi,

Morka,

Adesola

2023

jcbr

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The plant Anogeissus leiocarpus is traditionally used in the treatment of ulcers including gastric ulcers. Effervescent granules are unique, pleasant-tasting oral formulations which are ingested as liquids. This study is a preliminary development and evaluation of effervescent granules of the aqueous extract of the stem bark of Anogeissus leiocarpus. The extract was obtained by drying the filtrate gotten from maceration of the dried, crushed stem bark in water. The acids (citric and tartaric acid) were each combined with the base (sodium bicarbonate) in 1:1 and 1:2 ratios and these were mixed with the extract using either the fusion or wet granulation method of preparation of effervescent granules. The granules were evaluated for their flow properties, moisture content, pH after dissolution, effervescent time and in vitro dissolution. Results show that granules prepared by the fusion method possessed better flow properties than those prepared by wet granulation. Moisture content of the granules was similar. Granules containing higher base content had higher pH (7.29 and 7.30) and faster effervescent time (86 -99 sec) than those containing equal ratio of acid and base with pH of 5.85 and 5.96 and effervescent time of 104 -150 sec. In vitro release was faster release from formulations containing higher base content (100 and 90.32 % respectively) than the other batches. Aqueous extract of the stem bark of Anogeissus leiocarpus can be suitably formulated into effervescent granules.

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“…The body parts are obtained, sometimes dried, and crushed into powder for oral ingestion, application on skin surfaces, or boiled with water before drinking [6,7]. Plants obtained from the forest treat fevers, respiratory infections, stomach aches, headaches, backaches, toothaches, and male sexual dysfunctions [8][9][10]. The traditional approach to treating and managing diseases with herbs and plants is widespread in Africa and Asia [11,12].…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolite Composition and Bioactivity of Genus Albizia: A Review

Sowe

2023

JSMARTech

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Traditional medicine is being revalued all around the world because of considerable research on various plant species and their therapeutic properties. Traditional medicinal beliefs and practices are deeply rooted in The Gambia, and forest resources are a source of plants for medicine. A study has estimated the presence of one hundred and fifty ( 150) plant species in The Gambia, distributed between 28 different plant families. Among the plant species, Albizia seems to possess numerous pharmacological properties. Albizia plants are high in secondary metabolites, according to phytochemical investigations, and pharmacological tests of plant extracts have demonstrated antibacterial, anti-inflammatory, and analgesic effects. Albizia plant components are used in traditional medicine to cure a variety of diseases like lung infections, asthma, pile, diarrhea, gonorrhea, ulcers, hemorrhoids, anxiety, depression, and insomnia. Different solvent extracts of the genus Albizia have demonstrated excellent efficacy against S

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Anti-ulcer Activity of Ethanol Root Extracts of Cassia sieberiana D.C. in Albino Rats

Cited by 5 publications

References 0 publications

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Preliminary physicochemical evaluation of effervescent granules of Anogiessius leocarpus stem bark extract

Secondary Metabolite Composition and Bioactivity of Genus Albizia: A Review

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