Anti-ulcer effect of Ranunculus millefoliatus on absolute alcohol-induced stomach ulceration

Abdoulrahman, Kamaran K.

doi:10.1016/j.sjbs.2023.103711

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The experimental results showed that the MDA content in mice increased significantly when ethanol caused gastric mucosal barrier damage, and the presence of WP prevented the excessive accumulation of MDA. It has been demonstrated that wheat peptides can downregulate MDA levels in mice with alcoholic gastric ulcers, and our findings are consistent with them [5,33]. In summary, WP can alleviate the oxidative stress of alcohol-induced gastric mucosal injury by promoting the expression of GSH, GSSG, and T-AOC and reducing the expression of MDA.…”

Section: Discussionsupporting

confidence: 89%

“…Under normal circumstances, the gastric mucosal barrier is composed of factors such as the mucus-bicarbonate-phospholipid barrier, the epithelial barrier, and the endothelial barrier, which work together to protect the integrity and functionality of the gastric mucosa [2]. When ingested in high concentrations, ethanol can directly erode the gastrointestinal tract, causing acute gastritis and gastric ulcers, which can further result in lesions such as perforation and cancer [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Gastroprotective Effect of Walnut Peptides: Mechanisms and Impact on Ethanol-Induced Acute Gastric Mucosal Injury in Mice

Yuan,

Wang,

Wang

et al. 2023

Nutrients

View full text Add to dashboard Cite

The objective of this research was to explore the protective impact of walnut peptides (WP) against ethanol-induced acute gastric mucosal injury in mice and to investigate the underlying defense mechanisms. Sixty male BALB-c mice were divided into five groups, and they were orally administered distilled water, walnut peptides (200 and 400 mg/kg bw), and omeprazole (20 mg/kg bw) for 24 days. Acute gastric mucosal injury was then induced with 75% ethanol in all groups of mice except the blank control group. Walnut peptides had significant protective and restorative effects on tissue indices of ethanol-induced gastric mucosal damage, with potential gastric anti-ulcer effects. Walnut peptides significantly inhibited the excessive accumulation of alanine aminotransferase (ALT), aspartate transferase (AST), and malondialdehyde (MDA), while promoting the expression of reduced glutathione (GSH), total antioxidant capacity (T-AOC), glutathione disulfide (GSSG), and mouse epidermal growth factor (EGF). Furthermore, the Western blot analysis results revealed that walnut peptides significantly upregulated the expression of HO-1 and NQO1 proteins in the Nrf2 signaling pathway. The defensive impact of walnut peptides on the gastric mucosa may be achieved by mitigating the excessive generation of lipid peroxides and by boosting cellular antioxidant activity.

show abstract

Section: Discussionsupporting

confidence: 89%