Anti-Ulcerative Effect of Curcumin-Galactomannoside Complex on Acetic Acid-Induced Experimental Model by Inhibiting Inflammation and Oxidative Stress

Oxidative Stress Does Not Influence Subjective Pain Sensation in Inflammatory Bowel Disease Patients

“…CAT activity measured in tissue homogenates was not significantly different between CD, UC, and control groups in a study by Bouzid et al [ 32 ]. Sheethal et al performed a study on mice with acetic acid-induced model of UC [ 13 ]. OS developed due to inflammatory condition led to amplified ROS generation in the colonic tissue with significant reduction of SOD, GPX, and CAT due to inefficacious scavenging of free radicals which increases ROS generation.…”

“…In experimental colitis models, induced by dextran sulfate sodium (DSS), GSH levels are decreased and can be restored to normal levels by antioxidants [ 4 ]. Also, in the acetic acid-induced colitis model, treatment with antioxidant formula increased significantly the levels of GSH, which clearly indicates the preventive action against free radicals [ 13 ].…”

“…In acetic acid induced colitis, total COX and COX-2 activity was significantly increased, and antioxidant treatment normalized those levels. In colitis environment, when COX-2 increases, more prostaglandins are produced [ 13 ].…”

“…Yuksel et al in contrary found a positive correlation between the OS index and CRP in CD patients, which indicated a connection between excess OS and higher inflammation [ 18 ]. Moreover, treatment with antioxidants in acetic acid colitis models led to reduction in CRP levels [ 13 ]. Szczeklik et al described a positive correlation between saliva MDA and GSH and CRP and CDAI [ 27 ].…”

“…The marker of this process is Thiobarbituric Acid Reactive Substances (TBARS) level [ 12 ]. Estimation of TBARS reflects the malondialdehyde (MDA) concentration- the final product of lipid peroxidation [ 13 ].…”