Anti-Ulcerogenic Efficacy and Mechanisms of Edible and Natural Ingredients in Nsaid-Induced Animal Models

Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models. Methods: A systematic literature search was conducted on PubMed, using the terms "herbal medicines" and "gastric ulcer", "herbal medicines" and "peptic ulcer", "food" and "peptic ulcer", "food" and "gastric ulcer", "natural ingredient" and "peptic ulcer", "natural ingredient" and "gastric ulcer", "alternative medicine" and "peptic ulcer", "alternative medicine" and "gastric ulcer", "complementary medicine" and "peptic ulcer", "complementary medicine" and "gastric ulcer" in papers published in English between January 1, 1960 and January 31, 2016, resulting in a total of 6146 articles containing these terms. After exclusion of studies not related prevention, not in NSAID model or using non-edible natural ingredients, 54 articles were included in this review.Results: Numerous studies have demonstrated that edible natural ingredients exhibit antiulcerogenic benefit in NSAIDinduced animal models. The mechanisms by which edible, ingredient-induced anti-ulcerogenic effects include stimulation of mucous cell proliferation, antioxidation, inhibition of gastric acid secretion, as well as inhibition of H(+), K(+)-ATPase activities. Utilization of edible, natural ingredients could be a safe, valuable alternative to prevent the development of NSAID-induced gastric ulcer, particularly for the subjects who are long-term users of NSAIDs.

Targeting NF‐κB/COX‐2 signaling by soyasaponin I alleviates diclofenac‐induced gastric ulceration in male albino rats

“…Although the NSAIDs‐induced complications can be largely avoided by the concurrent use of H2 receptor blockers and proton pump inhibitors, their use may still be associated with serious but uncommon adverse effects, including microscopic colitis, eosinophilic esophagitis, galactorrhea, hypergastrinemia, decreased bone density and osteoporosis 4 . On the other hand, previous studies have reported that natural constituents can successfully interfere with the occurrence of peptic ulcers in different animal models of NSAIDs exposure, suggesting the potential use of these products as an alternative remedy for protection against gastric ulcer in chronic NSAIDs‐using individuals 5 …”

“…4 On the other hand, previous studies have reported that natural constituents can successfully interfere with the occurrence of peptic ulcers in different animal models of NSAIDs exposure, suggesting the potential use of these products as an alternative remedy for protection against gastric ulcer in chronic NSAIDs-using individuals. 5 In recent decades, phytochemicals have been a focus of intense research because they have various health-promoting actions. 6 Soyasaponins are a class of phytocompounds commonly derived from legumes such as soya beans, lentils, and peas.…”

Study of the antiulcer activity of garden cabbage extract on the chronic acetic ulcer model in rats

“…It is difficult to overestimate the importance of plant preparations during periods of remission or stabilization of the pathological process, when they act as supportive ones, preventing exacerbations. Taking into account the effectiveness, tolerability and cost-effectiveness, phytotherapeutic drugs are not competing, but complementary to modern pharmacotherapy for the treatment of gastric and duodenal ulcers [5,6].…”

The role of hydrogen sulfide in gastric mucosal damage

“…An acute gastric mucosa damage is frequently initiated by alcohol consumption, prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs) and stress-induced mucosal damage 34. Currently, the main clinic treatment for this disease is antisecretory drugs such as histamine type 2 receptor antagonists and irreversible proton pump inhibitors 56. Although effective, long-term use will bring more serious complications and aggravate the condition 7.…”