Anti-Viral Surfaces in the Fight against the Spread of Coronaviruses

Kwiatkowska, A.; Granicka, Ludomira

doi:10.3390/membranes13050464

Cited by 4 publications

(2 citation statements)

References 183 publications

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“…After the initial two intramuscular doses of thirty micrograms of BNT162b2 mRNA, the antibody titers start to decline a few months after the final immunization; hence, a booster dose is required. Research has demonstrated that chitosan and its derivatives possess potential anti-SARS-CoV-2 action, operate as useful adjuvants in vaccines, and exhibit direct antiviral activity [ 111 ]. For instance, plasmid DNA encoding the nucleocapsid SARS-CoV-2 was delivered intranasally using chitosan nanoparticles as a stimulant.…”

Section: Nanovaccinesmentioning

confidence: 99%

Nanomedicine for the Treatment of Viral Diseases: Smaller Solution to Bigger Problems

Ghorai,

Shand,

Patra

et al. 2024

Pharmaceutics

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The continuous evolution of new viruses poses a danger to world health. Rampant outbreaks may advance to pandemic level, often straining financial and medical resources to breaking point. While vaccination remains the gold standard to prevent viral illnesses, these are mostly prophylactic and offer minimal assistance to those who have already developed viral illnesses. Moreover, the timeline to vaccine development and testing can be extensive, leading to a lapse in controlling the spread of viral infection during pandemics. Antiviral therapeutics can provide a temporary fix to tide over the time lag when vaccines are not available during the commencement of a disease outburst. At times, these medications can have negative side effects that outweigh the benefits, and they are not always effective against newly emerging virus strains. Several limitations with conventional antiviral therapies may be addressed by nanotechnology. By using nano delivery vehicles, for instance, the pharmacokinetic profile of antiviral medications can be significantly improved while decreasing systemic toxicity. The virucidal or virus-neutralizing qualities of other special nanomaterials can be exploited. This review focuses on the recent advancements in nanomedicine against RNA viruses, including nano-vaccines and nano-herbal therapeutics.

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Section: Nanovaccinesmentioning

confidence: 99%

Nanomedicine for the Treatment of Viral Diseases: Smaller Solution to Bigger Problems

Ghorai,

Shand,

Patra

et al. 2024

Pharmaceutics

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“…Designing new synthetic peptides can be used not only to enhance their antimicrobial effects but also for broader applications in various fields [ 21 ]. With the proper design and selection of amino acid sequences, synthetic peptides can be integrated into the surface matrix or the material of the product itself, thereby providing long-lasting protection against microbes [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Antimicrobial Peptide Design: Integration of Cell-Penetrating Peptides, Amyloidogenic Fragments, and Amino Acid Residue Modifications

Kravchenko,

Domnin,

Grishin

et al. 2024

IJMS

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The escalating threat of multidrug-resistant pathogens necessitates innovative approaches to combat infectious diseases. In this study, we examined peptides R23FS*, V31KS*, and R44KS*, which were engineered to include an amyloidogenic fragment sourced from the S1 protein of S. aureus, along with one or two cell-penetrating peptide (CPP) components. We assessed the antimicrobial efficacy of these peptides in a liquid medium against various strains of both Gram-positive bacteria, including S. aureus (209P and 129B strains), MRSA (SA 180 and ATCC 43300 strains), and B. cereus (strain IP 5832), and Gram-negative bacteria such as P. aeruginosa (ATCC 28753 and 2943 strains) and E. coli (MG1655 and K12 strains). Peptides R23FS*, V31KS*, and R44KS* exhibited antimicrobial activity comparable to gentamicin and meropenem against all tested bacteria at concentrations ranging from 24 to 48 μM. The peptides showed a stronger antimicrobial effect against B. cereus. Notably, peptide R44KS* displayed high efficacy compared to peptides R23FS* and V31KS*, particularly evident at lower concentrations, resulting in significant inhibition of bacterial growth. Furthermore, modified peptides V31KS* and R44KS* demonstrated enhanced inhibitory effects on bacterial growth across different strains compared to their unmodified counterparts V31KS and R44KS. These results highlight the potential of integrating cell-penetrating peptides, amyloidogenic fragments, and amino acid residue modifications to advance the innovation in the field of antimicrobial peptides, thereby increasing their effectiveness against a broad spectrum of pathogens.

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Bimodal Magneto‐Luminescent Response of Lanthanide Metallopolymers for Distinguishing of Phosphates in Aqueous Solutions

Dovzhenko,

Vasilyev,

Kornev

et al. 2024

Macro Chemistry & Physics

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Linear N‐substituted polyacrylamides bearing tricarboxylic moieties pendant to the backbone are synthesized, and coordinative binding approach is developed to convert them into Gd3+/Eu3+‐metallopolymers. Inner‐sphere coordination of the lanthanide ions with the pendant chelating moieties, together with their outer‐sphere stabilization by the randomly coiled backbone, are the reasons for peculiar water proton relaxation and luminescence properties of the metallopolymers obtained. Indeed, for Gd3+‐metallopolymer, the values of longitudinal and transverse relaxivity (r1 and r2) are 50 and 60 mm−1·s−1, respectively, while for the Eu3+‐counterpart, Eu3+‐centered luminescence is significantly raised compared to Eu3+ aquaions. Coil‐like conformation of the metallopolymer molecules undergoes a swelling at pH values above 5.0 as evidenced by transmission electron microscopy TEM and dynamic light scattering (DLS) data, which is followed by the changes in the Eu3+‐centered luminescence and r1(2)‐values of Gd3+/Eu3+‐metallopolymers. The phosphates additives (adenosine monophosphoric acid (AMP), adenosine diphosphoric acid (ADP), HPO42− and adenosine triphosphoric acid (ATP) induce well detectable changes in both water proton relaxation and luminescence of Gd3+/Eu3+‐metallopolymers. The luminescent changes distinguish AMP from the other phosphates, while the changes in water proton relaxation are greater for HPO42− and ATP compared to AMP and ADP. This study explains this by interplay of the effects associated with the formation of ternary phosphate‐lanthanide‐polymer complexes and stripping of lanthanide ions from the polymer molecules.

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Anti-Viral Surfaces in the Fight against the Spread of Coronaviruses

Cited by 4 publications

References 183 publications

Nanomedicine for the Treatment of Viral Diseases: Smaller Solution to Bigger Problems

Nanomedicine for the Treatment of Viral Diseases: Smaller Solution to Bigger Problems

Optimizing Antimicrobial Peptide Design: Integration of Cell-Penetrating Peptides, Amyloidogenic Fragments, and Amino Acid Residue Modifications

Bimodal Magneto‐Luminescent Response of Lanthanide Metallopolymers for Distinguishing of Phosphates in Aqueous Solutions

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