Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L.) leaf tea in diet-induced obese mice

Lee, Hae-In; Kim, Mi-Su; Lee, Kyung-Mi; Park, Seok-Kyu; Seo, Kwon‐Il; Kim, Hye-Jin; Kim, Myung‐Joo; Choi, Myung‐Sook

doi:10.1016/j.fct.2011.06.049

Cited by 46 publications

(37 citation statements)

References 48 publications

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“…A potential chemopreventive effect of sea buckthorn berries in mice was observed by Suryakumar and Gupta (2011). In high-fat diet-induced obese mice sea buckthorn leaf tea proved their antioxidant effect and effect of visceral obesity reduction (Lee et al 2011).…”

Section: Antioxidant Effects and Immunomodulating Propertiesmentioning

confidence: 97%

Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - a review

et al. 2015

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Sea buckthorn (Hippophae rhamnoides L.) is in the focus of interest mainly for its positive effects on health of both human and animal organisms. The whole plant of sea buckthorn and especially its berries are a source of a large number of different bioactive compounds. The greatest attention has been drawn to its high content of vitamins, minerals, natural antioxidants, n-3 and n-6 fatty acids, and proteins. Sea buckthorn is valued for its antioxidant, cardioprotective, antiatherogenic, antidiabetic, hepatoprotective, anti-carcinogenic, immunomodulatory, antiviral, antibacterial, anti-inflammatory and vasorelaxant effects. Due to these and other positive effects, the plant is included in both human and animal nutrition, in the latter case to increase the biological value of animal products. This review summarises the botanical characteristics of sea buckthorn, lists the bio-active substances contained in individual parts of the plant, their effects in the prevention of a number of different diseases and their possible utilisation in human and animal nutrition.

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Section: Antioxidant Effects and Immunomodulating Propertiesmentioning

confidence: 97%

Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - a review

et al. 2015

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“…3) The leaf has been reported to have anti-inflammatory, 7) antioxidant, 4) anti-obesity, 8,9) and α-glucosidase inhibitory activities.…”

mentioning

confidence: 99%

“…3 ) The leaf has been reported to have anti-inflammatory, 7) antioxidant, 4) anti-obesity, 8,9) and α-glucosidase inhibitory activities. 4) In our previous study, we investigated anti-obesity and antiinflammatory compounds that not only inhibit triglyceride (TG) accumulation by 3T3-L1 adipocytes but also inhibit the secretion of nitric oxide (NO) from RAW264.7 cells.…”

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confidence: 99%

Inhibitory Effects of the Constituents of <i>Hippophae rhamnoides</i> on 3T3-L1 Cell Differentiation and Nitric Oxide Production in RAW264.7 Cells

Yang

Wen

et al. 2013

Chem. Pharm. Bull.

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Three new flavonol glycosides, hippophaeosides A-C (1-3), together with 27 known constituents, were isolated from Hippophae rhamnoides L. leaves. Their structures were determined by spectroscopic analyses. Their inhibitory activities on 3T3-L1 preadipocyte differentiation and triglyceride accumulation in maturing adipocytes, and nitric oxide production in RAW264.7 cells were examined.Key words Hippophae rhamnoides; flavonol glycoside; triterpenoid; adipocyte; macrophage Hippophae rhamnoides L. (Elaeagnaceae), known as "sea buckthorn," is a deciduous shrub distributed throughout Asia and Europe. The fruit has been used as a traditional medicine for the treatment of cough indigestion and blood stasis in China.1) Investigations of H. rhamnoides have yielded flavonols, 2-4) triterpenoids, 5,6) and tannins.3) The leaf has been reported to have anti-inflammatory, 7) antioxidant, 4) anti-obesity, 8,9) and α-glucosidase inhibitory activities. 4)In our previous study, we investigated anti-obesity and antiinflammatory compounds that not only inhibit triglyceride (TG) accumulation by 3T3-L1 adipocytes but also inhibit the secretion of nitric oxide (NO) from RAW264.7 cells. In that study, several crude drugs were examined. [10][11][12] In the present study, the 80% methanol extract of the leaves of H. rhamnoides L. and the chloroform-and ethyl acetatesoluble portions of the extract were observed to inhibit the TG accumulation in 3T3-L1 cells, and inhibit NO production in lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activated macrophages. Furthermore, an attempt to identify the bioactive compounds present in this plant led to the isolation of three new flavonol glycosides, Hippophaeosides A (1), B (2), and C (3), along with 27 known constituents. Results and DiscussionThe leaves of H. rhamnoides L. were extracted with 80% aqueous methanol, followed by evaporation of the solvent under reduced pressure from the combined extract to give the 80% methanol extract. The extract [TG and NO inhibitory activity: 35% and 63%, respectively (30 µg/mL) [42, 15% (30 µg/mL)]. We focused our efforts on investigating the chemical constituents of the chloroform-and ethyl acetate-soluble fractions. The ethyl acetate layer was separated by Sephadex LH-20 column chromatography to yield four fractions from which 22 compounds including three new compounds 1-3 were isolated. Eight compounds were isolated from the chloroform layer. Compounds 4-30 were identified by detailed comparisons of their

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“…Decreased G6PD and ME activities may suggest that there is an adaptive reaction to excess dietary fat. Fatty acid synthesis and storage have important roles in metabolic homeostasis [3,20]. In this study, the activities of G6PD and ME responsible for fatty acid synthesis in mice treated with YH tended to be lower than those in mice not treated with YH.…”

Section: Discussionmentioning

confidence: 79%

“…The free fatty acids are then broken down for energy production via β-oxidation. Lipid homeostasis is maintained by the fine-tuning of lipogenesis and lipolysis, which are regulated by the cooperative action of various enzymes in metabolic organs such as the liver [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Yeast Hydrolysate on Hepatic Lipid Metabolism in High-Fat-Diet-Induced Obese Mice: Yeast Hydrolysate Suppresses Body Fat Accumulation by Attenuating Fatty Acid Synthesis

et al. 2012

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Aims: We observed whether the anti-obesity activity of yeast hydrolysate (YH) was due to the alteration of lipid-regulating enzyme activities. Methods: Male ICR mice were divided into four groups: a normal diet group (ND; 4.2% fat), a high-fat diet group (HF; 27.7% fat), an HF group treated orally with 0.5% or 1% YH in the drinking water (HF+YH0.5; 27.7% fat and HF+YH1; 27.7% fat). Results: After 5 weeks, the YH groups (HF+YH0.5 = 3.92 ± 0.17 g/100 g BW and HF+YH1 = 3.76 ± 0.13 g/100 g BW) had significantly lower levels of epididymal fats compared to the HF group (4.91 ± 0.29 g/100 g BW; p < 0.05). YH supplementation produced a decrease in serum triglycerides and low-density lipoprotein cholesterol concentrations and body weight gain, and produced a dose-dependent significant increase in serum ghrelin compared with the HF group (p < 0.05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH exhibited a significant decrease in hepatic malic enzyme (ME) activity compared to obese mice treated with the vehicle (HF = 10.44 ± 2.74 nmol/min/mg protein vs. HF+YH1 = 6.68 ± 2.23 nmol/min/mg protein; p < 0.05). Conclusions: YH supplementation suppressed body fat accumulation by attenuating fatty acid synthesis through the downregulation of hepatic G6PD and ME activities.

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Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L.) leaf tea in diet-induced obese mice

Cited by 46 publications

References 48 publications

Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - a review

Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - a review

Inhibitory Effects of the Constituents of <i>Hippophae rhamnoides</i> on 3T3-L1 Cell Differentiation and Nitric Oxide Production in RAW264.7 Cells

Effects of Yeast Hydrolysate on Hepatic Lipid Metabolism in High-Fat-Diet-Induced Obese Mice: Yeast Hydrolysate Suppresses Body Fat Accumulation by Attenuating Fatty Acid Synthesis

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