Anti‐wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation

Cho, Ho-Song; Lee, Minho; Lee, Jae Woong; No, Kyong-Ok; Park, Sang-Ki; Lee, Heon-Sik; Kang, Sung Soo; Cho, Wan-Goo; Park, Hye Ji; Oh, Ki Wan; Hong, Jin Tae

doi:10.1111/j.1600-0781.2007.00298.x

Cited by 98 publications

(67 citation statements)

References 30 publications

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“…* Pycnogenol, an extract of French maritime pine (Pinuspinaster Ait), prevents UV induced erythema as well as long-term effects, such as immune-suppression and tumour formation [17,18]. It also possesses regenerative skin properties, and prevents UVBinduced photo-aging [19,20]. * Fernblock, an extract obtained from the fern Polypodium leucotomos, inhibits UVB and PUVA therapy-induced erythema in vivo [21].…”

Section: Antioxidantsmentioning

confidence: 99%

Sunscreens and Antioxidants as Photo-protective Measures: An update

Hassan¹,

Dorjay²,

Sami³

et al. 2013

Our Dermatol Online

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There are many photo-protective measures adopted for protection from the solar radiation especially the UV radiation spectrum, sunscreens being the main agents. Besides the traditional approach of topical use of sunscreens, both chemical and physical, a new approach has emerged to use systemic agents in the form of vitamins and minerals. In this review, we are describing the major aspects related to sunscreens and anti-oxidants as photo-protective measures.

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Section: Antioxidantsmentioning

confidence: 99%

Sunscreens and Antioxidants as Photo-protective Measures: An update

Hassan¹,

Dorjay²,

Sami³

et al. 2013

Our Dermatol Online

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show abstract

“…Antioxidants are used in the cosmetic industry to prevent the formation of new wrinkles and reduce skin ageing caused by UV radiation. These antioxidants, such as vitamin C, vitamin E and pycnogenol, have been shown to have a synergistic effect when combined for UV protection [33]. Photostabilizers have also been shown to exhibit antioxidant properties.…”

Section: Antioxidantsmentioning

confidence: 99%

Review of sunscreen and the emergence of non-conventional absorbers and their applications in ultraviolet protection

Morabito

Shapley

Steeley

et al. 2011

International Journal of Cosmetic Science

168

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SynopsisProtection against ultraviolet (UV) radiation is the major function of sunscreen lotions and UV-protective coatings for vehicles, homes, equipment and clothing. Sunscreen formulations have been optimized to become protective over a broader spectrum of UV radiation and maintain greater photostability. They are comprised of organic and inorganic components that act as chemical and physical UV protectors, respectively. Some of the organic components are limited by their spectrum of protection and photostability. Studies using solid lipid nanoparticles, recently explored organic molecules, inorganic components and antioxidants attempt to further optimize UV protection. In this review, we examine traditional and emerging nanoparticle components and highlight novel ideas in UV protection which may provide pathways for future studies. Ré suméLa protection contre les rayons ultraviolets (UV) est la principale fonction des crèmes solaires et des revêtements de protection UV pour les véhicules, les logements, les équipements et les vêtements. Les formulations solaires ont été optimisées pour devenir des protections de large spectre UV et pour maintenir une plus grande photo stabilité. Ils sont composés de matières organiques et inorganiques qui agissent comme des produits de protection respectivement chimique et physique contre les UV. Certains des composants organiques sont limités par leur spectre de protection et leur photo stabilité. Les études récentes de nanoparticules lipidiques solides (SLN) des molécules organiques, inorganiques et antioxydants, ont exploré des voies d'optimisation de protection UV. Dans cette revue, nous examinons les composants traditionnels et les nanoparticules émergentes ainsi que les idées de protection UV pour proposer de futures études.

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“…For this purpose, skin samples from sham-irradiated or chronically UV-exposed hairless mice, which at the time of biopsy showed significant signs of photoaging including increased wrinkle formation, reduced numbers of collagen fibers and increased expression of matrix metalloproteinase-13, 39 were analyzed for LOX mRNA expression. In all animals, LOX mRNA expression was significantly increased as compared with sham-irradiated control animals ( Figure 8A).…”

Section: In Vivo Lox Expressionmentioning

confidence: 99%

Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts

Majora

Wittkampf

Schuermann

et al. 2009

The American Journal of Pathology

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Deletions within the mitochondrial DNA (mtDNA) are thought to contribute to extrinsic skin aging. To study the translation of mtDNA deletions into functional and structural changes in the skin , we seeded human skin fibroblasts into collagen gels to generate dermal equivalents. These cells were either derived from Kearns-Sayre syndrome (KSS) patients, who constitutively carry large amounts of the UV-inducible mitochondrial common deletion, or normal human volunteers. We found that KSS fibroblasts, in comparison with normal human fibroblasts, contracted the gels faster and more strongly, an effect that was dependent on reactive oxygen species. Gene expression and Western blot analysis revealed significant upregulation of lysyl oxidase (LOX) in KSS fibroblasts. Treatment with the specific LOX inhibitor ␤-aminopropionitrile decreased the contraction difference between KSS and normal human fibroblast equivalents. Also, addition of the antioxidant N-tert-butyl-␣-phenylnitrone reduced the contraction difference by inhibiting collagen gel contraction in KSS fibroblasts, and both ␤-aminopropionitrile and N-tert-butyl-␣-phenylnitrone diminished LOX activity. These data suggest a causal relationship between mtDNA deletions, reactive oxygen species production, and increased LOX activity that leads to increased contraction of collagen gels. Accordingly, increased LOX expression was also observed in vivo in photoaged human and mouse skin. Therefore, mtDNA deletions in human fibroblasts may lead to functional and structural alterations of the skin.

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Anti‐wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation

Abstract: Oral administration of the antioxidant mixture significantly inhibited wrinkle formation caused by chronic UVB irradiation through significant inhibition of UVB-induced MMP activity accompanied by enhancement of collagen synthesis.

Cited by 98 publications

References 30 publications

Sunscreens and Antioxidants as Photo-protective Measures: An update

Sunscreens and Antioxidants as Photo-protective Measures: An update

Review of sunscreen and the emergence of non-conventional absorbers and their applications in ultraviolet protection

Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts

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