Antiadenoviral Activity of Titanium Dioxide Nanoparticles

Pankivska, Yu.B.; Biliavska, L.O.; Povnitsa, Olga; Zagornyi, M.M.; Ragulia, A.V.; Kharchuk, M.S.; Zagorodnya, Svіtlana

doi:10.15407/microbiolj81.05.073

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…In the past 10 years, TiO 2 nanopowder through photocatalytic activity, chemical resistance and non-toxic can be used as an effective agent for the treatment of organic and inorganic substances, pathogens of various types in the environment [7][8][9][10]. The unique properties of TiO 2 , especially nanoscale one, used to address important energy and environmental issues have caused the recent emergence of large scientific works on the synthesis and study of its antivirus properties and then search for ways of its practical application The antiviral activity of TiO 2 anatase nanoparticles against human adenovirus 5 serotypes was between 45% and 95% dependence on particles size [8].…”

Section: Methods Of Preparation and Properties Of Composites With Tio...mentioning

confidence: 99%

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Synthesis, Structure and Biomedical Application of Nanosize Composites Based on Oxide Semiconductor and Metal (Review)

2021

Nanosistemi, Nanomateriali, Nanotehnologii

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Today, nanocomposites based on magnetite (Fe 3 O 4 ), zinc oxide (ZnO), titanium oxide (TiO 2 ) doped with metal cations are widely used to create new kinds of biocompatible materials, which are characterized by unique complexes of physical-chemical properties. The semiconducting-nanoparticles' coating by metals leads to their stabilization in corrosive biological media and affects their electrical, magnetic, catalytic, and plasmonic properties too. The achievements during recent years in the field of producing composites based on nanosize particles of different nature are demonstrated in a given review article. The basic methods for materials' preparation, properties, and the possible fields of their application are summarized.Сьогодні нанокомпозити на основі магнетиту (Fe 3 O 4 ), оксиду Цинку (ZnO), оксиду Титану (TiO 2 ), леґованих катіонами металів, широко використовуються для створення нових видів біосумісних матеріялів, що характеризуються унікальними комплексами фізико-хемічних властивостей. Покриття напівпровідникових наночастинок металами приводить до стабілізації їх у корозійних біологічних середовищах і впливає також на їхні електричні, магнетні, каталітичні та плазмонні властивості. Досягнення останніх років у галузі виробництва композитів на основі нанорозмірних частинок різної природи продемонстровано в даній оглядовій статті. Підсумовано основні методи підготовки матеріялів, властивості та можливі сфери застосування їх.

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Section: Methods Of Preparation and Properties Of Composites With Tio...mentioning

confidence: 99%

“…The inclusion of noble metal cations in the crystal lattice of iron oxides enhances their optical properties [1-2]. In addition, effect of UV irradiation on metal oxide catalysts promotes to appearance their photobactericidal activity [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Biomedical Application of Nanosize Composites Based on Oxide Semiconductor and Metal (Review)

2021

Nanosistemi, Nanomateriali, Nanotehnologii

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“…Nowadays, different kinds of methods, including shape, size, and facet control, element doping have been developed to effectively enhance the photocatalytic performance through increasing the broad absorption of sunlight, prolonging the lifetime of photoinduced carriers, and enhancing the optical activity and photocatalytic stability of TiO 2 . For example, via shape control, doping with metal or non-metal elements, dye-sensitization, and construction of heterostructured photocatalyst systems by combining them with plasmonic metals (i.e., Ag, Au, Pd, Pt) or other semiconductors [4][5][6][7][8][9][10]. Noble metal nanoparticles (NPs) can show SPR (surface plasmonic resonance), which can be tailored by engineering the shape, size, and surroundings [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ag Content on the Structural, Optical, and Cytotoxicity Properties of TiO2 Nanopowders Grown from TiO(OH)2 Precursor by the Chemical Deposition Method

2021

Nanosistemi, Nanomateriali, Nanotehnologii

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А series of Ag/TiO 2 is prepared by the chemical deposition method using silver nitrate and suspension of TiO(OH) 2 following sonication and treatment up 600C. Silver nanoparticles are deposited on the surface and inside of TiO 2 nanoparticles depending on the Ag concentration. The Ag/TiO 2 composites are characterized by x-ray diffraction, transmission electron microscopy, scanning electron microscopy, Raman and photoluminescence spectroscopies. The optical activity of Ag/TiO 2 with significant attenuation of photoluminescence in the range of 480-600 nm, a shift of mode E g from 143 to 150 cm 1 and FWHM from 12 to 19 cm 1 are revealed due to decreasing of TiO 2 crystallites. The optical activity is increased after loading with Ag because metal particles offer electron traps to decrease the recombination of holes and electrons, especially, with Ag loading of 8 wt.%. The obtained results indicate lower toxicity of nanoparticles in the glycer-inewater suspension; regardless of the introduction of silver molecules in amount of 4 or 8 wt.%, their CC 50 values are of 50 g/mL and 3.9-58.5 g/mL for the MDBK and MDCK cells, respectively. Instead, TiO 2 nanoparticles in C 2 H 5 OH1.3-propanediol with the introduction of silver mole-

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“…Фотокаталітичну активність наночастинок TiO 2 значно підвищує додавання до нанодіоксиду титану певної кількості срібла (нано-TiO 2 -Ag) [1]. Виражена фотокаталітична активність зумовлює високу біологічну дію наночастинок TiO 2 -віруцидну, бактерицидну, фунгіцидну [2,3].…”

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Toxicological and morphological aspects of nano-TiO2 and nano-TiO2-Ag acute action on the liver of mice

Yavorovskyi,

Savosko,

Riabovol

et al. 2023

Patologìâ

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Aim. To study the toxic effect of TiO2 and TiO2-Ag nanopowders on the morphology and elemental composition of the laboratory mice liver. Materials and methods. The study used a model of acute intoxication on laboratory animals. Mice were injected intraperitoneally with TiO2 and TiO2-Ag nanopowders at 4000 mg/kg, 7000 mg/kg, or 10000 mg/kg doses. During two weeks, the animals were observed, lethality was assessed, the accumulation of nanopowder in the organ and the morphology of liver tissues were investigated. The content of titanium and silver in liver samples was determined by optical emission spectroscopy with inductively coupled plasma. Liver tissue micropreparations were examined using an Olympus BX51 light microscope. Also, the micropreparations of the liver were examined by scanning electron microscopy (SEM) using the Tescan Mira 3 device, and the elemental composition was determined using an energy dispersive spectrometer Oxford instrument, X-max 80 mm2. Results. The dependence of the mice lethality on the nanopowders dose was revealed; mortality was higher when exposed to nano-TiO2-Ag compared to nano-TiO2. Average lethal doses were calculated using probit analysis. For nano-TiO2, the LD50 is 4783.30 mg/kg; for nano-TiO2-Ag – 724.44 mg/kg. The accumulation of titanium, titanium, and silver in the liver after exposure to nano-TiO2 and nano-TiO2-Ag was established. In general, there was a tendency to increase the content of titanium in the skin tissue with an increase in the administered dose of nanopowders. Morphological changes in the liver were studied by histological methods. The most characteristic morphological signs of the toxic effect of nano-TiO2 on tissue were dystrophic changes at the level of 67.7 % (cytoplasmic vacuolization in hepatocytes), and when exposed to nano-TiO2-Ag – initial necrotic changes at the level of 70 % (hepatocytes with nuclear pyknosis). It is worth noting that the toxic effect of nano-TiO2 and nano-TiO2-Ag is much less often manifested by focal necrosis and inflammatory reactions (focal infiltration), in some cases, there were adaptive changes that provoked an increase in the number of binuclear hepatocytes. In case of detection agglomerates of a foreign object (crystalline inclusions) were obtained, which were examined spectrally and showed a high content of titanium (Ti). SEM morphometry showed that the size of nanoparticles and their agglomerates ranged from 80 nm to 20 μm. Conclusions. The lethality of mice was higher when the composition of nano-TiO2-Ag was introduced compared to nano-TiO2. Based on the calculated average lethal doses, both nanopowders were assigned to the 3rd class (moderately dangerous) of the danger of chemical substances according to the classification of GOST 12.1.007-76. It was established that with an increase in the injected dose in the tissue of the products of laboratory mice, the accumulation of titanium (under the action of nano-TiO2) and titanium and silver (under the action of nano-TiO2-Ag) increases. Characteristic microscopic signs of the toxic effect of TiO2 and TiO2-Ag nanopowders after intraperitoneal injection in laboratory bags are dystrophic changes in hepatocytes, necrosis of parenchymal disease, while inflammatory reactions occur less often. SEM and the method of elemental mapping of titanium confirmed the presence of TiO2 nanoparticles and their agglomerates in skin tissue when TiO2 nanopowder was administered.

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Antiadenoviral Activity of Titanium Dioxide Nanoparticles

Cited by 6 publications

References 17 publications

Synthesis, Structure and Biomedical Application of Nanosize Composites Based on Oxide Semiconductor and Metal (Review)

Synthesis, Structure and Biomedical Application of Nanosize Composites Based on Oxide Semiconductor and Metal (Review)

The Effect of Ag Content on the Structural, Optical, and Cytotoxicity Properties of TiO2 Nanopowders Grown from TiO(OH)2 Precursor by the Chemical Deposition Method

Toxicological and morphological aspects of nano-TiO2 and nano-TiO2-Ag acute action on the liver of mice

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