Antiadhesive effect and safety of sodium hyaluronate-carboxymethyl cellulose membrane in thyroid surgery

Abstract

PurposeA number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the antiadhesive effect and safety of HA-CMC membrane in thyroidectomy for papillary thyroid cancer.MethodsOne hundred sixty-two patients who underwent thyroidectomy were prospectively randomized. In the study group of 80 patients, the 7.5 cm × 13 cm HA-CMC membrane was applied to the operative field after thyroidectomy. The subjects were asked about complications including adhesive symptoms using an 8-item questionnaire at 2 weeks, 3 months, and 6 months after surgery. In addition, items on the appearance of neck wrinkles and scars were evaluated by a physician who had no information about the patient's allocation.ResultsThere were no significant differences in complications such as swallowing difficulty, and wrinkles between study and control groups. Both groups presented significantly decreased scores over time in swallowing difficulty, and wrinkles. There were no complications regarding the HA-CMC membrane.ConclusionThe antiadhesive effect of HA-CMC membrane in thyroid surgery is still uncertain, although it is biologically safe. Further investigation is needed to confirm the antiadhesive effect of HA-CMC membrane in thyroid surgery.

Network meta-analysis of topical haemostatic agents in thyroid surgery

“…Overall, thirteen RCTs were included in the meta‐analysis. Eight potentially relevant full texts were excluded ( Fig . ).…”

Robotic thyroidectomy and cervical neck dissection for thyroid cancer

“…Excellent cosmetic outcomes and reductions in pain and dysphagia have also been reported with this technique (17)(18)(19)(20)(21). Robotic thyroid surgery is particularly prevalent in Korea, where more than 8,000 cases of robotic thyroidectomy were performed from 2007 to 2011 (2,000 procedures in 2011 alone) (22).…”

Evaluation of the effects of hyaluronic acid-carboxymethyl cellulose barrier on ovarian tumor progression

“…On the contrary, HA-CMC barrier has not been showed to be associated with increased complications in thyroid surgery despite an uncertain anti-adhesive effect [24]. …”