Antiadhesive Properties of Glycoclusters against <i>Pseudomonas aeruginosa</i> Lung Infection

Boukerb, Amine M.; Rousset, Audric; Galanos, Nicolas; Méar, Jean-Baptiste; Thépaut, Marion; Grandjean, Teddy; Gillon, Émilie; Cecioni, Samy; Abderrahmen, Claire; Faure, Karine; Redelberger, David; Kipnis, Éric; Dessein, Rodrigue; Havet, Stéphane; Darblade, B.; Matthews, Susan E.; Bentzmann, Sophie de; Guéry, B.; Cournoyer, Benoît; Imberty, Anne; Vidal, Sébastien

doi:10.1021/jm500038p

Cited by 123 publications

(130 citation statements)

References 51 publications

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“…[78] To treat these infections is becoming difficult day by day due to emergence of antimicrobial multiresistance against most of the available drugs. Recently, keeping in view the beneficial effect of monosaccharides against such bacterial lung infections, [79] Vidal and co-worker [80] have synthesized several multivalent calix [4]arene-based glycoclusters of type 12 (Scheme 7) through azide-alkyne 1,3-dipolar cycloaddition and characterized their antiadhesive properties against Pseudomonas aeruginosa through several in vitro bioassays. Interestingly, the designed glycoclusters have provided an almost complete protection against Pseudomonas aeruginosa in mouse model (in vivo) of lung infection.…”

Section: S C H E M E 2 Synthesis Of Calixcephem 5 S C H E M E 3 Synthmentioning

confidence: 99%

Functionalized calix[4]arenes as potential therapeutic agents

2017

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Calixarenes, composed of phenolic units linked by methylene bridges at the 2,6-positions, represent a versatile class of macrocyclic compounds in supramolecular chemistry that can host small molecules or ions in their well-defined hydrophobic cavities. In recent years, it has been recognized that this class of compounds has the potential to serve as platform for the design of biological active compounds. Therefore, the calixarenes functionalized with different pharmacophoric groups have been synthesized as target structure by many researchers and were further evaluated for their biological activities. Owing to their promising biological activities such as antiviral, antibacterial, antifungal, and anticancer, the functionalized calixarenes are recently receiving increased attention from pharmaceutical/medicinal chemistry community. In this review, we summarize and discuss the synthetic approaches and the biological potential of functionalized calixarenes, mainly focusing on the selected recent studies for a comprehensive and target-oriented information, which could help in the design and synthesis of new therapeutic agents leading to the development of clinically viable drugs based on these macrocyles. K E Y W O R D Sbiological activity, calixarenes, cone conformation, functionalization, upper/lower rim/annulus

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Section: S C H E M E 2 Synthesis Of Calixcephem 5 S C H E M E 3 Synthmentioning

confidence: 99%

Functionalized calix[4]arenes as potential therapeutic agents

2017

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“…Almost ten years have passed since the seminal review [2] notably for the control of P. aeruginosa adhesion and biofilm formation [78,79]. Although FimHmediated adhesion seems to be effectively controlled also by monomannosides of extended aromatic aglycones, most of the current antiadhesive technologies employ high-valency glycoclusters.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Sattin

Bernardi

2016

Trends in Biotechnology

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Microbial adhesion is an essential step of infections and is mediated primarily by proteincarbohydrate interactions. Antagonists of such interactions have become a promising target for antiadhesive therapy in a number of infective diseases. Monovalent protein-sugar interactions are often weak, and most successful antiadhesive materials consist of multivalent glycoconjugates.Although often very effective in hampering microbial adhesion, natural epitopes often show limited resistance to enzymatic degradation. The use of carbohydrate mimics (glycomimetics) as a replacement for natural sugars potentially allows to achieve higher metabolic stability and also higher selectivity towards the desired protein target. In this review we will describe the state of the art on the design and synthesis of glycoconjugates and glycomimetics employed for the construction of antiadhesive biomaterials.

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“…In addition, these monosaccharides displayed synergistic effect when used in combination with antibiotics such as b-lactams and fluoroquinolone [88]. In a recent study, multivalent glycosylated macromolecules functionalized with galactosides or fucoside for lectin targeting were designed to combat P. aeruginosa infection [89]. The authors demonstrated that these multivalent glycocluster inhibited bacterial adhesion while simultaneously protected host against lung injury in mouse pulmonary lung infection model [89].…”

Section: Secretion Of Conditioning Layers Irreversible Attachment Andmentioning

confidence: 99%

Implications and emerging control strategies for ventilator-associated infections

Loo

Lee

Young

et al. 2015

Expert Review of Anti-infective Therapy

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Ventilator-associated pneumonia (VAP) remains a major burden to the healthcare system and intubated patients in intensive care units. In fact, VAP is responsible for at least 50% of prescribed antibiotics to patients who need mechanical ventilation. One of the factors contributing to VAP pathogenesis is believed to be rapid colonization of biofilm-forming pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus on the surface of inserted endotracheal tubes. These biofilms serve as a protective environment for bacterial colonies and provide enhanced resistance towards many antibiotics. This review presents and discusses an overview of current strategies to inhibit the colonization and formation of biofilm on endotracheal tubes, including antibiotic treatment, surface modification and antimicrobial agent incorporation onto endotracheal tube materials.

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Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

Cited by 123 publications

References 51 publications

Functionalized calix[4]arenes as potential therapeutic agents

Functionalized calix[4]arenes as potential therapeutic agents

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Implications and emerging control strategies for ventilator-associated infections

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