Antiaging effect of Cordyceps sinensis extract

Abstract

This experiment studied the effect of Cordyceps sinensis extract (CSE) on mice aged by D-galactose and castrated rats to analyse its antiaging effect. Water maze and step-down type avoidance tests were used to examine the effect of CSE on learning and memory. CSE shortened escape latency, prolonged step-down latency and decreased the number of errors in mice aged by D-galactose. The effect of CSE on the sexual function of castrated rats was evaluated by measuring the penis erection latency, mount latency and ejaculation latency. CSE appeared to shorten penis erection latency and mount latency in castrated rats. The study also measured the effect of CSE on the activity of age-related enzymes. The results showed that CSE improved the activity of superoxide dismutase, glutathione peroxidase and catalase and lowered the level of lipid peroxidation and monoamine oxidase activity in the aged mice. The study demonstrated that CSE can improve the brain function and antioxidative enzyme activity in mice with D-galactose-induced senescence and promote sexual function in castrated rats. All of these findings suggest that CSE has an antiaging effect.

Medicinal Value of Cordyceps sinensis

“…The result suggested that stimulation of the M1mAchR by CCh was the key factor leading to ERK phosphorylation enhanced by extract of CS. Pretreatment with DCM and PIR exhibited drastic inhibition of CCh induced ERK phosphorylation [12].…”

“…The toxicity of STZ was being suppressed by CS. Moreover, findings suggested that CS reduced the complication related to Diabetes Mellitus like improvement in electrolyte balance and decrease in deposition of collagen fibril in histopathological examination of renal cortical over the control model which is a typical feature of Diabetic nephropathy [12].…”

“…2 degeneration in mice treated with CSE compared to control group mice, suggesting the enhancement of brain function by CSE [12,13]. [14][15][16].…”

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

“…[7,8,12,14,15,24,39,48,52,66,67,83,92,98,107,121,136,140,161,162,167,173,177,178,180,188,194,200,207,208,[210][211][212]. [164].…”

Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201

“…Moreover, tyrosinase-inhibitory activities from Cordyceps extracts exhibit a suppressing effect of melanin production (18). Additionally, anti-depressant, anti-oxidation, hepatoprotective, anti-diabetic, and anti-aging activities from various extracts of Cordyceps exhibited a wide range of bioactivity in vitro, as well as in vivo (19)(20)(21)(22)(23)(24).…”