Antiaging Effects of Musa sapientum L. (Banana) Leaf Extract

Abstract

To examine the possibility of using Musa sapientum L. (Banana) leaf extract as a cosmetic raw material, banana leaves grown in Jeju Island were extracted with 70% ethanol. Polysaccharides present in banana leaf extract were discarded by precipitation with cold ethanol. Polysaccharidediscarded banana leaf extract promoted procollagen and COL1A1 gene expression, but inhibited matrix metalloproteinase (MMP)-1 and MMP-2 gene expression in human skin fibroblasts when examined by real-time reverse-transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). The active compound in banana leaves was identified by fractionation with various solvents. The chloroform fraction showed the highest anti-wrinkle efficacy and the active compound of chloroform fraction was identified as corosolic acid by NMR, FT-IR, EA, and HPLC-MS. In addition, banana leaf extract showed anti-oxidative efficacy with an IC50 value of 67.91 ppm, as determined by DPPH free radical scavenging assay. Finally, the anti-wrinkle efficacy of banana leaf extract-containing cream was confirmed by clinical tests. Based on these results, banana leaves could have an application as a cosmetic raw material with anti-wrinkle efficacy.

Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq

“…MMPs degrade extracellular matrix (ECM) components, such as collagen, elastin, and gelatin. Of the known MMPs, MMP1 encodes interstitial collagenase, specifically degrading the collagen triple helix, while MMP2 encodes gelatinase A, degrading denatured collagen, gelatin, and elastin [ 29 ]. About 30% of the human body's proteins are collagen.…”

Musa sapientum L. (banana): potential for drug development

“…Different parts of M. sapientum used for antioxidant activity tests, such as fruit peel, pulp, seed and flower, showed antioxidant potential of the plant, especially the fruit in different concentrations and different solvents used in the extraction [20,22,23,58,59,56,60].…”

“…Aesthetics is an area that is growing in the market, thus necessitating the search for natural cosmetics that have the ability to combat the main complaints. Fibroblasts are responsible for the production of collagen and elastin that contribute to the fight against aging in the aesthetic context, Yoo et al ( 2016) [60] concluded that the ethanolic extract of M. sapientum leaves has the ability to promote the expression of procollagen and COL1A1 genes, demonstrating the ability to be a raw material of a cosmetic with efficacy in wrinkles.…”