Antialgal compounds with antialgal activity against the common red tide microalgae from a green algae Ulva pertusa

Sun, Yingying; Zhou, Wenjing; Wang, Hui; Guo, Ganlin; Su, Zhenxia; Pu, Yong

doi:10.1016/j.ecoenv.2018.03.051

Cited by 26 publications

(22 citation statements)

References 24 publications

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“…Biological methods, which rely on allelochemicals from aquatic plants to constrain harmful algal blooms, have become a research hotspot for their high biodegradability, low toxicity, and low cost [7,8,9]. Seagrasses are submerged marine aquatic plants that play an important role in coastal ecosystems such as providing food and habitat for animals, taking up metals, and contributing to the primary production [10].…”

Section: Introductionmentioning

confidence: 99%

Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Zhu

Han

Chen

et al. 2019

IJERPH

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Enhalus acoroides (E. acoroides) is one of the most common species in seagrass meadows. Based on the application of allelochemicals from aquatic plants to inhibit harmful algal blooms (HABs), we used E. acoroides aqueous extract against harmful algae species Phaeocystis globosa (P. globosa). The results showed that E. acoroides aqueous extract could significantly inhibited the growth of P. globosa, decrease the chlorophyll-a content and photosynthetic efficiency (Fv/Fm) values of P. globosa, followed by vacuolization, plasmolysis, and the destruction of organelles. Twelve types of major chemical constituents were identified in E. acoroides aqueous extracts by ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS), including six flavonoids, two homocyclic peptides, two long-chain aliphatic amides, one tannin, and one nitrogen heterocyclic compound. Flavonoids were the characteristic chemical constituents of E. acoroides aqueous extract. Furthermore, the antialgal activity of luteolin-7-O-glucuronide (68.125 μg/mL in 8 g/L E. acoroides aqueous extract) was assessed. The EC50–96 h value was 34.29 μg/mL. In conclusion, the results revealed that luteolin 7-O-glucuronide was one of the antialgal compounds of E. acoroides aqueous extract, with potential application as novel algaecide.

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Section: Introductionmentioning

confidence: 99%

Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Zhu

Han

Chen

et al. 2019

IJERPH

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“…Recent studies indicated that the production of ROS in M. aeruginosa cells can induce various antioxidant responses such as increasing the activities of the antioxidant enzymes superoxide dismutase, peroxidase and catalase (Hua et al ., 2018; Sun et al ., 2018; Wang et al ., 2018b; Hou et al ., 2019; Gao et al ., 2020; Kang et al ., 2020; Li et al ., 2020). In general, SOD acts as the first defence line of cell’s antioxidant responses against ROS by converting superoxide O 2 ‐ to oxygen and H 2 O 2 , which is further eliminated by CAT (Hua et al ., 2018; Sun et al ., 2018; Wang et al ., 2018b; Hou et al ., 2019; Gao et al ., 2020; Kang et al ., 2020; Li et al ., 2020). However, CAT is an important enzyme promoting the conversion of H 2 O 2 to ground state oxygen and water (Hua et al ., 2018; Sun et al ., 2018; Wang et al ., 2018b; Hou et al ., 2019; Gao et al ., 2020; Kang et al ., 2020; Li et al ., 2020).…”

Section: Discussionmentioning

confidence: 99%

“…3). The observed increase in SOD and CAT activities suggests that enzymes are involved to eliminate oxidative stress (Hua et al ., 2018; Sun et al ., 2018; Wang et al ., 2018b; Hou et al ., 2019; Gao et al ., 2020; Kang et al ., 2020; Li et al ., 2020).…”

Section: Discussionmentioning

confidence: 99%

“…In general, SOD acts as the first defence line of cell's antioxidant responses against ROS by converting superoxide O 2 -to oxygen and H 2 O 2 , which is further eliminated by CAT (Hua et al, 2018;Sun et al, 2018;Wang et al, 2018b;Hou et al, 2019;Gao et al, 2020;Kang et al, 2020;Li et al, 2020). However, CAT is an important enzyme promoting the conversion of H 2 O 2 to ground state oxygen and water (Hua et al, 2018;Sun et al, 2018;Wang et al, 2018b;Hou et al, 2019;Gao et al, 2020;Kang et al, 2020;Li et al, 2020). In our study, the SOD and CAT activities of M. aeruginosa cells were significantly increased (P < 0.05) by the different concentrations of the three MEA extracts tested (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effect and mechanism of three macrophytes extract on Microcystis aeruginosa growth and physiology

Tazart

Caldeira

Douma

et al. 2020

Water & Environment J

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Macrophytes are a promising source of bioactive compounds with potential applications in the biocontrol of harmful cyanobacteria blooms. In this study, we investigated the inhibitory effects of extracts from three macrophytes (Nasturtium officinale, Potamogeton natans and Ranunculus aquatilis) on Microcystis aeruginosa. We assessed physiological indicators of inhibition on M. aeruginosa, including lipid peroxidation, protein content, superoxide dismutase activity, catalase activity and growth. The chemical composition of the macrophyte extracts and their specific allelochemicals were analysed using high‐performance liquid chromatography (HPLC). Results showed that M. aeruginosa growth was significantly inhibited after 8 days of exposure, with inhibitory rate varying from 96.98% to 99.01%. The macrophyte extracts caused cyanobacterial cell membrane and antioxidant defence system damage. Thirteen different compounds were identified as allelochemical compounds that could be responsible for M. aeruginosa growth inhibition and oxidative stress. Our findings suggest that allelopathic compounds from macrophytes may be used to effectively control cyanobacteria blooms and promote the restoration of aquatic ecosystems.

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“…Additionally, some biological methods using living organisms, such as algae-fed aquatic birds or fish, algicidal bacteria, and viruses can be applied to control HABs; nevertheless, these methods lack technical stability and are likely to change or even destruct the current ecosystem [4,12]. Over the last decade, the application of antialgal compounds extracted from plants, such as Ulva pertusa , Cinnamomum camphora , Arundo donax , Ascophyllum nodosum , Sagittaria trifolia , Stratiotes aloides , and Eichhornia crassipes have been applied to control HABs; this approach has shown to be effective and has great potential to eliminate harmful algae, but to date, the antialgal mechanism is still not clear [13,14,15,16,17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

The Antialgal Mechanism of Luteolin-7-O-Glucuronide on Phaeocystis globosa by Metabolomics Analysis

Zhu

Yang

Duan

et al. 2019

IJERPH

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Antialgal compounds from plants have been identified as promising candidates for controlling harmful algal blooms (HABs). In our previous study, luteolin-7-O-glucuronide was used as a promising algistatic agent to control Phaeocystis globosa (P. globose) blooms; however, its antialgal mechanism on P. globosa have not yet been elaborated in detail. In this study, a liquid chromatography linked to tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomic approach was used to investigate changes in intracellular and extracellular metabolites of P. globosa after exposure to luteolin-7-O-glucuronide. Significant differences in intracellular metabolites profiles were observed between treated and untreated groups; nevertheless, metabolic statuses for extracellular metabolites were similar among these two groups. For intracellular metabolites, 20 identified metabolites showed significant difference. The contents of luteolin, gallic acid, betaine and three fatty acids were increased, while the contents of α-Ketoglutarate and acetyl-CoA involved in tricarboxylic acid cycle, glutamate, and 11 organic acids were decreased. Changes in those metabolites may be induced by the antialgal compound in response to stress. The results revealed that luteolin played a vital role in the antialgal mechanism of luteolin-7-O-glucuronide on P. globosa, because luteolin increased the most in the treatment groups and had strong antialgal activity on P. globosa. α-Ketoglutarate and acetyl-CoA were the most inhibited metabolites, indicating that the antialgal compound inhibited the growth through disturbed the tricarboxylic acid (TCA) cycle of algal cells. To summarize, our data provides insights into the antialgal mechanism of luteolin-7-O-glucuronide on P. globosa, which can be used to further control P. globosa blooms.

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Antialgal compounds with antialgal activity against the common red tide microalgae from a green algae Ulva pertusa

Cited by 26 publications

References 24 publications

Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Growth Inhibition of Phaeocystis Globosa Induced by Luteolin-7-O-glucuronide from Seagrass Enhalus acoroides

Inhibitory effect and mechanism of three macrophytes extract on Microcystis aeruginosa growth and physiology

The Antialgal Mechanism of Luteolin-7-O-Glucuronide on Phaeocystis globosa by Metabolomics Analysis

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