Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations

Ito, Hisatomi; Miyazaki, Toshitsugu; Ono, Mariko

doi:10.1016/s0968-0896(98)00063-7

Cited by 79 publications

(53 citation statements)

References 21 publications

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“…PCA reaction. 21) ER and its constituents evodiamine and rutaecarpine inhibited mouse PCA reaction induced by IgEantigen complex. Evodiamine and rutaecarpine showed potent antiscratching behavioral effect, although ER weakly inhibited scratching behaviors induced by compound 48/80.…”

Section: Resultsmentioning

confidence: 94%

In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents

Shin

Bae

Cai

et al. 2007

Biological & Pharmaceutical Bulletin

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Allergic diseases, such as allergic rhinitis, atopic dermatitis, asthma and food allergy, are now rapidly increasing chronic health problem in most countries.1) Mast cells and basophils are well-known as a critical participant in various biologic processes of allergic diseases.2-4) These cells express on their surface membrane receptors with high affinity and specificity for IgE. The interaction of multivalent antigens with surface-bound IgE releases histamine, prostaglandins, leukotrienes and cytokines. 5,6) These cytokines activate chemotaxis and phagocytosis of neutrophils and macrophages. Finally cytokine-induced reaction causes tissue inflammation. Therefore, antiallergic agents, such as anti-histamines, steroids and immunosuppressants, have been using against allergic diseases. 7-9) However, improving these diseases is too difficult. Therefore, herbal medicines have been advanced for allergic diseases, and its effectiveness has received increasing attention. 10,11) The unripe fruit of Evodia rutaecarpa (JUSS) BENTH (ER, Family Rutaceae) have been used in Korea, Japan and China as a traditional herbal medicine. ER, which contains quninzoline alkaloids, such as ruatecarpine and evodiamine, as main components, is reported to have many biological properties including stimulation of vasodilation, positive cardiotonic effects, inhibition of pain, and inhibition of prostaglandin production.12-15) Nevertheless, its pharmacological studies mainly have been focused on anti-inflammatory activity.Therefore, to evaluate its antiallergic activity, we isolated main components from the fruit of Evodia rutaecarpa and in vivo evaluated their inhibitory activities against scratching behaviors and anaphylaxis. The unripe fructus of Evodia rutaecarpa was extracted with 80% ethanol and rutaecarpine (purity >95%) and evodiamine (purity >95%) (Fig. 1) were isolated from the fruits of E. rutaecarpa and structurally identified according to the previous reports. 11,12,16) Animals The male ICR mice (20-25 g) and male Sprague-Dawley rats were supplied from Orient Experimental Animal Breeding Center (Seoul, Korea). All animals were housed in wire cages at 20-22°C and 50Ϯ10% humidity, fed standard laboratory chow (Orient Experimental Animal Breeding Center, Seoul, Korea) and allowed water ad libitum. All procedures relating to animals and their care conformed to the international guidelines 'Principles of Laboratory Animals Care' (NIH publication no. 85-23, revised 1985). MATERIALS AND METHODS MaterialsMeasurement of Passive Cutaneous Anaphylaxis (PCA) Reaction An IgE-dependent cutaneous reaction was measured according to the previous method of Choo et al.17) The male ICR mice were injected intradermally with 10 mg of anti-DNP IgE into each of two dorsal skin sites that had been shaved 48 h earlier. The sites were outlined with a water-insoluble red marker. Forty-eight hours later each mouse received an injection of 200 ml of 3% Evans blue PBS containing 200 mg of DNP-HSA via the tail vein. The test agents The unripe fruit of Evodia ru...

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Section: Resultsmentioning

confidence: 94%

In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents

Shin

Bae

Cai

et al. 2007

Biological & Pharmaceutical Bulletin

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“…These results support the reports that antioxidants are useful for treating allergic diseases. 30) Daidzein also had the most potent inhibitory activity against the PCA reaction. These results suggest that, when puerarin and daidzin are administered orally, it is easily metabolized to daidzein in intestine, and daidzein is absorbed into blood and is responsible for the inhibitory activity against PCA reaction.…”

Section: Discussionmentioning

confidence: 94%

Antithrombotic and Antiallergic Activities of Daidzein, a Metabolite of Puerarin and Daidzin Produced by Human Intestinal Microflora.

Choo

Park

Yoon

et al. 2002

Biological & Pharmaceutical Bulletin

101

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The rhizome of Pueraria lobata (family Leguminosae) is frequently used for the liver diseases, strokes, and allergy as a crude substance taken orally in Asian countries as a traditional ingredient of polyprescriptions.1) Some isoflavones, puerarin, and daidzin, were isolated from the rhizome of Pueraria lobata as the main component.2,3) Among them, daidzin has acetaldehyde dehydrogenase and cAMP phosphoesterase inhibitory and antispasmatic activities, [4][5][6] and puerarin has hypoglycemic and coronary artery blood flow increasing activity. 7,8) Most herbal medicines are administered orally and their components are inevitably brought into contact with intestinal microflora in the alimentary tract. Most components are metabolized by the intestinal bacteria before absorption from the gastrointestinal tract.9) Related to the metabolism of puerarin and daidzin, Yasuda et al. reported that daidzein and its conjugates were found in the urine of rats orally administered puerarin and daidzin. 10,11) We also reported that puerarin and daidzin are transformed to daidzein and calycosin by human intestinal microflora. Based on these findings, we thought that these compounds could be metabolized to their aglycones by intestinal bacteria before absorption into the blood and expression of their pharmacological actions. However, the relationship between the pharmacological actions, such as antithrombotic and antiallergic effects, and the metabolism of these compounds by human intestinal microflora was not completely clarified.Therefore we investigated the antithrombotic and antiallergic activities of puerarin, daidzin, and daidzein, which is a metabolite of puerarin and daidzin produced by human intestinal microflora. MATERIALS AND METHODSMaterials Adenosine 5Ј-diphosphate (ADP), epinephrine, collagen, bovine serum albumin, prothrombin, thromboplastin, thrombin, hyaluronidase from bovine testis, p-nitrophenyl N-acetyl-b -D-glucosaminide, anti-dinitrophenol (DNP)-IgE, DNP-bovine serum albumin (BSA), Evans blue, hyaluronic acid potassium salts, azelastine, xanthine oxidase (XOD), 2,2-diphenyl-1-picrylhydrzyl (DPPH), and disodium cromoglycate (DSCG) were purchased from Sigma Chemical (U.S.A.). Puerarin and daidzin were isolated from the rhizome of P. lobata according to the method of Kakegawa et al.,[12][13][14] and daidzein was isolated according to our previous method.15) The other chemicals were of analytical reagent grade.Animals Sprague-Dawley rats (male, 180-220 g) and ICR mice (male, 20-24 g) were purchased from Sam Yook Animal Co. (Korea) and acclimatized for 1 week at a temperature of 22Ϯ1°C and humidity of 55Ϯ5% with free access to a commercial pellet diet (Samyang Co., Korea) and drinking water before the experiments. Animal experiments were carried out in accordance with international guidelines.Preparation of Platelets Blood from rats was collected by cardiac puncture into a plastic flask containing 2.2% sodium citrate (1 : 9 v/v). Platelet-rich plasma (PRP) was prepared by centrifugation of the blood at 120ϫg for 1...

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“…Rosmarinic acid (RA), a natural phenolic, is found in many Lamiaceae herbs, such as Perilla frutescens Linn., sage, basil, and mint. The medicinal value of RA has been well recognized, especially in regard to its antioxidant and antiinflammatory activities (Ito et al, 1998). RA has been reported to inhibit complement-dependent inflammatory processes (Zupko et al, 2001) and may have therapeutic potential (al-Sereiti et al, 1999).…”

Section: Herbs With Antiapoptotic Potential In Cardiovascular Disordersmentioning

confidence: 99%

Antiapoptotic potential of herbal drugs in cardiovascular disorders: An overview

Ahmad

Javed

Bhandari

2010

Pharmaceutical Biology

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Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations

Cited by 79 publications

References 21 publications

In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents

In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents

Antithrombotic and Antiallergic Activities of Daidzein, a Metabolite of Puerarin and Daidzin Produced by Human Intestinal Microflora.

Antiapoptotic potential of herbal drugs in cardiovascular disorders: An overview

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