Antiamnesic activity of Syzygium cumini against scopolamine induced spatial memory impairments in rats

Alikatte, Kanaka Latha; Akondi, Butchi Raju; Yerragunta, Venu Gopal; Veerareddy, Prabhakar Reddy; Palle, Suresh

doi:10.1016/j.braindev.2012.02.008

Cited by 46 publications

(24 citation statements)

References 26 publications

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“…It can be defined as the capability of a person to record pieces of information, and retain and recall them whenever needed, and moreover use this information to adapt responses to the environment, therefore it is essential for survival (1). Learning is the process of acquisition of information and skills, while subsequent retention of that information is called memory.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Red Lentil Hydroalcoholic Extract on Retention and Retrieval of Memory in Young and Aged Mice

Nooshabadi

Arzi

Houshmand

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Since ancient times, people have believed that certain foods or plants can affect learning and memory potency in humans. The consumption of food and beverages rich in flavonoid compounds has been proposed as a way to restrict the neurodegeneration associated with many neurological complications and to reverse or prevent deterioration in cognitive performance. Objectives: In the present study, we have attempted to show the effect of red lentil extract (RLE), an edible legume with a high quantity of flavonoid, on retrieval and retention of memory in young and aged animals with the use of a passive avoidance apparatus. Materials and Methods:For the experiments, after coding, the animals (128 total) were weighted and classified into different groups as follows: Group 1 as a control received only electric shock, while group 2 as a blank received electric shock plus normal saline (1 mL/100 g). The test groups (groups 3 and 4) received electric shock plus 400 and 800 mg/kg ip. RLE, respectively. The delay in leaving the platform of avoidance apparatus was measured for both retrieval and retention tests of memory in all groups, whereas experiments were conducted on two age levels -young and aged mice. In the test of retention after getting electric shock, RLE immediately, whereas in the test of retrieval 23.5 hours after the shock was administered. Results: Our findings demonstrated where applying both 400 mg/kg and 800 mg/kg of RLE significantly increased (the latency time increased about 2-and 3-fold respectively in comparison with the control group) retention and retrieval (at least 7-fold compared to the control group) of the memory of young (P < 0.05) and aged (P < 0.01) mice. Conclusions: It can be concluded that the devisable memory-enhancing effects of red lentil (lens culinaris) are due to the antioxidant activity of its flavonoid, tannins, and terpenoids.

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Section: Introductionmentioning

confidence: 99%

The Effect of Red Lentil Hydroalcoholic Extract on Retention and Retrieval of Memory in Young and Aged Mice

Nooshabadi

Arzi

Houshmand

et al. 2016

Jundishapur J Nat Pharm Prod

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show abstract

“…Each arm (50 x 12 cm) of the eight-arm radial maze extends from an octagonal shaped central hub of 30 cm diameter. The platform is elevated 40 cm above the floor, small black metal cups (3 cm in diameter & 1 cm deep) are mounted at the end of each arm that serve as receptacles for reinforces food [3]. The rats of all groups were tested for working memory errors on the 8 th day of treatment with respective drugs [13].…”

Section: Evaluation Of Nate Effect Using Radial Arm Maze Testmentioning

confidence: 99%

“…It was divided in to two equal chambers (27×29×25 cm) by Plexiglas partition, with a gate providing access to the adjacent compartment through a 14×17 cm space. Numbers of avoidances were observed on the last day of the treatment with the standard and test drugs [3].…”

Section: Evaluation Of Nate Effect Using Active Avoidance Testmentioning

confidence: 99%

“…A circular platform was placed at a place approximately 1 cm below the water surface. All the animals were trained before the experiment with normal water and then the platform was hidden by mixing with milk [3].…”

Section: Evaluation Of Nate Effect Using Morris Water Maze Testmentioning

confidence: 99%

“…Cognitive impairment is achieved by inducing an acetylcholine muscarinic receptor antagonist i.e. scopolamine [3].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nyctanthes arbor tristis leaf extract against scopolamine-induced cognitive impairment in rats

Phanindhra¹,

Raju

Vikas³

et al. 2015

Herba Polonica

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S u m m a r yNyctanthes arbor tristis (NATE) ethanol extract (150 mg/kg, orally) was evaluated for its protective effect against scopolamine-induced (1 mg/kg i.p.) cognitive impairments in rats using behavioral models like radial arm maze test, Morris water maze test and active avoidance test. NATE effect was evaluated and compared with the standard piracetam (200mg/kg i.p.). NATE (p<0.005) significantly reversed the impairment produced by the scopolamine in radial arm maze test. In addition, NATE also decreased the time period taken to find the hidden platform in Morris water maze test and increased number of avoidances in active avoidance paradigm. Acetylcholinesterase activity and thiobarbituric acid levels were significantly (p<0.005) decreased along with the rise in activities of superoxide dismutase and catalase. This might suggest that the NATE has protective effect against scopolamine-induced cognitive impairment in rats through acetylcholine muscarinic receptor pathway and also antioxidant activity. No significant changes were found in histopathological studies of brain.

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Chemical Characterization, Biological Activities, and Some Medicinal Uses of Different Sweet Basil (Ocimum basilicum L.) Genotypes

Yaldız

Çamlıca

Pradhan

et al. 2022

Springer Protocols Handbooks

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Antiamnesic activity of Syzygium cumini against scopolamine induced spatial memory impairments in rats

Cited by 46 publications

References 26 publications

The Effect of Red Lentil Hydroalcoholic Extract on Retention and Retrieval of Memory in Young and Aged Mice

The Effect of Red Lentil Hydroalcoholic Extract on Retention and Retrieval of Memory in Young and Aged Mice

Effect of Nyctanthes arbor tristis leaf extract against scopolamine-induced cognitive impairment in rats

Chemical Characterization, Biological Activities, and Some Medicinal Uses of Different Sweet Basil (Ocimum basilicum L.) Genotypes

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