Antiamnesic Effect of Broccoli (Brassica oleracea var. italica) Leaves on Amyloid Beta (Aβ)1–42-Induced Learning and Memory Impairment

Park, Seon Kyeong; Ha, Jeong Su; Kim, Jong Min; Kang, Jin Yong; Lee, Du Sang; Guo, Tian; Lee, Uk; Kim, Dae‐Ok; Heo, Ho Jin

doi:10.1021/acs.jafc.6b00559

Cited by 36 publications

(26 citation statements)

References 35 publications

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“…; Park et al . ). These activities are attributed to the presence of bioactive compounds such as vitamin C, carotenoids, polyphenols, glucosinolates, sulforaphane and enzymes (e.g.…”

Section: Introductionmentioning

confidence: 97%

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Antimicrobial activity of broccoli (Brassica oleracea var. italica ) cultivar Avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast

et al. 2017

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“…; Park et al . ). These activities are attributed to the presence of bioactive compounds such as vitamin C, carotenoids, polyphenols, glucosinolates, sulforaphane and enzymes (e.g.…”

Section: Introductionmentioning

confidence: 97%

“…We suggest for first time that the inhibitory effect is probably due to AMPs. 2011;Mahn and Reyes 2012;Owis 2015;Vinha et al 2015;Park et al 2016). These activities are attributed to the presence of bioactive compounds such as vitamin C, carotenoids, polyphenols, glucosinolates, sulforaphane and enzymes (e.g.…”

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confidence: 99%

Antimicrobial activity of broccoli (Brassica oleracea var. italica ) cultivar Avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast

et al. 2017

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“…Furthermore, the development of senile plaques composed of extracellular accumulated β-amyloid (Aβ) peptides [2] is one of the most distinct neuropathological features of AD. It is hypothesized that Aβ peptides are toxic and contribute to memory loss, behavioral impairments, and further neurodegenerative pathology in AD [3,4]. In addition to Aβ aggregation, neuroinflammation also plays a pivotal role in the pathophysiology of AD [5].…”

Section: Introductionmentioning

confidence: 99%

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

Zhao

et al. 2020

J Neuroinflammation

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Background: Alzheimer's disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical ginger sesquiterpene, in transgenic APP/PS1 mice, rodent models of AD which exhibit cerebral amyloidosis and neuroinflammation. Methods: The N9 microglial cell line and primary microglial cells were cultured to investigate the effects of zerumbone on microglia. APP/PS1 mice were treated with zerumbone, and non-cognitive and cognitive behavioral impairments were assessed and compared between the treatment and control groups. The animals were then sacrificed, and tissues were collected for further analysis. The potential therapeutic mechanism of zerumbone and the signaling pathways involved were also investigated by RT-PCR, western blot, nitric oxide detection, enzyme-linked immunosorbent assay, immunohistochemistry, immunofluorescence, and flow cytometry analysis. Results: Zerumbone suppressed the expression of pro-inflammatory cytokines and induced a switch in microglial phenotype from the classic inflammatory phenotype to the alternative anti-inflammatory phenotype by inhibiting the mitogen-activated protein kinase (MAPK)/nuclear factor-kappa B signaling pathway in vitro. After a treatment period of 20 days, zerumbone significantly ameliorated deficits in both non-cognitive and cognitive behaviors in transgenic APP/PS1 mice. Zerumbone significantly reduced β-amyloid deposition and attenuated pro-inflammatory microglial activation in the cortex and hippocampus. Interestingly, zerumbone significantly increased the proportion of anti-inflammatory microglia among all activated microglia, potentially contributing to reduced β-amyloid deposition by enhancing phagocytosis. Meanwhile, zerumbone also reduced the expression of key molecules of the MAPK pathway, such as p38 and extracellular signal-regulated kinase. Conclusions: Overall, zerumbone effectively ameliorated behavioral impairments, attenuated neuroinflammation, and reduced β-amyloid deposition in transgenic APP/PS1 mice. Zerumbone exhibited substantial anti-inflammatory activity in microglial cells and induced a phenotypic switch in microglia from the pro-inflammatory phenotype to the antiinflammatory phenotype by inhibiting the MAPK signaling pathway, which may play an important role in its neuroprotective effects. Our results suggest that zerumbone is a potential therapeutic agent for human neuroinflammatory and neurodegenerative diseases, in particular AD.

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“…italic. In previous study, chloroform fraction of broccoli leaf extract has been reported to ameliorate Aβ 1-42 induced learning and memory impairment, to enhance cognitive function evaluated by Y-maze, passive avoidance, and MWM tests.and inhibition against AChE [43]. It may be speculated that consumption of the broccoli may have potential for the management of dementia clinically.…”

Section: Resultsmentioning

confidence: 92%

Antidementic Activity of Brassica oleracea L. var. Italica (Brassicaceae) Flower on Memory Deficit in Young Male Rats

Ashwlayan¹

2017

PPIJ

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Memory deficit is major health problem in normal life and in numerous psychiatric and neurodegenerative states during which patients forget recent happenings and become profoundly disabled, mute, immobile over 5-10 years. Brassica oleracea L. var. italica (Broccoli) was investigated for its anti-dementic activity on memory deficit induced by scopolamine (0.3 mg/kg, i.p.) in young male rats using behavioural models [elevated plus maze (EPM) & Morris water maze (MWM)]. Brain malondialdehyde (MDA), nitrite and reduced glutathione (GSH) biomarkers were also estimated to assess oxidative potential of broccoli. Its flower extract was prepared with hydro-alcohol (1:1) solvent using Soxhlet apparatus. Two doses (40 and 80 mg/kg, p. o.) of Hydro-alcoholic flower extract of Brassica oleracea L. var. italica (HFEBOI) were administered for four consecutive days to separate groups of rats. Chronic pretreatment with HFEBOI (40 and 80 mg/kg, p. o.) significantly and dose dependently improved learning and memory of rats, as indicated by increase in inflation ratio using EPM, and decrease in ELT during acquisition and increase in time spent in target quadrant (TSTQ) during retrieval using MWM. The drugs did not show any significant effect on loco-motor activity of the rat. Oxidative stress biomarkers (elevated brain MDA, nitrite and lower GSH levels) in scopolamine induced memory deficit in rats were significantly reversed by the flower extract. HFEBOI significantly reversed scopolamine induced memory deficit in rats. HFEBOI also significantly reduced brain acetylcholinesterase (AChE) activity of rats. The results indicated potential of HFEBOI in relieving memory deficit and oxidative stress induced by scopolamine. Anti-dementic mechanism of Brassica oleracea L. var. italica may be mediated through the inhibition of brain AChE activity by diindolylmethane, an anti-ChE and oxidative stress leading to rejuvenation of central nervous system that relieves dementia.

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Antiamnesic Effect of Broccoli (Brassica oleracea var. italica) Leaves on Amyloid Beta (Aβ)_1–42-Induced Learning and Memory Impairment

Cited by 36 publications

References 35 publications

Antimicrobial activity of broccoli (Brassica oleracea var. italica ) cultivar Avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast

Antimicrobial activity of broccoli (Brassica oleracea var. italica ) cultivar Avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

Antidementic Activity of Brassica oleracea L. var. Italica (Brassicaceae) Flower on Memory Deficit in Young Male Rats

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