Antiamoebins, myrocin B and the basis of antifungal antibiosis in the coprophilous fungus Stilbella erythrocephala (syn. S. fimetaria)

Lehr, Nina-A.; Meffert, Anja; Antelo, Luís T.; Sterner, Olov; Anke, Heidrun; Weber, Roland W.S.

doi:10.1111/j.1574-6941.2005.00007.x

Cited by 38 publications

(34 citation statements)

References 29 publications

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“…Eupenicillium bovifimosum present in cow dung produces patulodine-like compounds viz. CK2108A and CK2801B that possess significant antigungal activity (Dorothy and Frisvad 2002;Lehr et al 2006). Lauková et al (1998) detected considerable numbers of enterococci in cow dung water with antilisterial effect.…”

Section: Human Health Managementmentioning

confidence: 99%

Current status of cow dung as a bioresource for sustainable development

Gupta

Aneja

Rana

2016

Bioresour. Bioprocess.

213

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Cow dung, an excreta of bovine animal, is a cheap and easily available bioresource on our planet. Many traditional uses of cow dung such as burning as fuel, mosquito repellent and as cleansing agent are already known in India. Cow dung harbours a diverse group of microorganisms that may be beneficial to humans due to their ability to produce a range of metabolites. Along with the production of novel chemicals, many cow dung microorganisms have shown natural ability to increase soil fertility through phosphate solubilisation. Nowadays, there is an increasing research interest in developing the applications of cow dung microorganisms for biofuel production and management of environmental pollutants. This review focuses on recent findings being made on cow dung that could be harnessed for usage in different areas such as medicine, agriculture and industry.

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Section: Human Health Managementmentioning

confidence: 99%

Current status of cow dung as a bioresource for sustainable development

Gupta

Aneja

Rana

2016

Bioresour. Bioprocess.

213

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“…S. erythrocephala) has also been proven when growing on rabbit dung in the field. Production of up to 624 mg peptide/g fresh weight was observed [17]. Species of Stilbella and Emericellopsis produce particularly large amounts of peptaibiotics [18].…”

mentioning

confidence: 99%

Aib and Iva in the Biosphere: Neither Rare nor Necessarily Extraterrestrial

Brückner

Becker

Gams³

et al. 2009

Chemistry & Biodiversity

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Fourty-nine species and strains of filamentous fungi of the genera Acremonium, Bionectria, Clonostachys, Emericellopsis, Hypocrea/Trichoderma, Lecythophora, Monocillium, Nectriopsis, Niesslia, Tolypocladium, and Wardomyces, deposited with the culture collection of the Centraalbureau voor Schimmelcultures (CBS) in Utrecht, The Netherlands, were grown on nutrient agar plates. Organic extracts of mycelia were analyzed after acidic total hydrolysis and derivatization by GC/SIM-MS on Chirasil-L-Val for the presence of Aib (=alpha-aminoisobutyric acid, 2-methylalanine) and DL-Iva (=isovaline, 2-ethylalanine). In 37 of the hydrolysates, Aib was detected, and in several of them D-Iva or mixtures of D- and L-Iva. Non-proteinogenic Aib, in particular, is a highly specific marker for a distinctive group of fungal polypeptides named peptaibols or, comprehensively, peptaibiotics, i.e., peptides containing Aib and displaying (anti)biotic activities. The biotic synthesis of these amino acids by filamentous fungi contradicts the still widespread belief that alpha,alpha-dialkyl-alpha-amino acids do not or rarely occur in the biosphere and, if detected, are of extraterrestrial origin. The abundant production of peptaibiotics by cosmopolitan species of microfungi has also to be considered in the discussion on the occurrence of Aib and Iva in ancient and recent sediments. The detection of trace amounts of Aib in ice samples of Antarctica that are devoid of meteorites might also be related to the presence of Aib-producing microorganisms, being either indigenous psychrophiles, or being transported and localized by mechanisms related to bioaerosols and cryoconites. The presence of microfungi being capable of producing alpha,alpha-dialkyl alpha-amino acids in terrestrial samples, and possible contamination of extraterrestrial materials are pointed out to be of relevance for the reliable interpretation of cosmogeochemical data.

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“…Some meteorites, such as the Murchison, contain Aib as well as non-racemic mixtures of chiral C a -dialkylamino acids, indeed [210]. However, based on the abundance of data presented here, a microbial origin of Aib and Iva in sediments cannot be excluded [12] [104] [165]. Notably, recently peptaibiotics were partially sequenced in fresh and frozen marine sediments collected in France [200].…”

Section: Peptaibiomics and Intact Cell Maldi-tof-ms -Two State-of-thementioning

confidence: 90%

“…Clonostachys rosea f. catenulata) CBS 511.66, Emericellopsis synnematicola CBS 176.60, and E. salmosyn-nemata CBS 382.62 [164]. Notably, Lehr et al were -six years later -first to unequivocally prove that antiamoebins were responsible for antibiosis in colonized herbivore dung [165]. Four strains of Stilbella fimetaria (syn.…”

Section: Electrospray Ionization Ms (Esi-ms) Revolutionizes the Reseamentioning

confidence: 97%

“…The diterpene antibiotic myrocin B, not previously described from S. fimetaria, was also produced, but only at low, nonfungicidal levels (5.3 mg/g). As no other antifungal substances could be detected, a decisive role of the broad-spectrum antimycotic AAM during colonization of dung was proposed [165]. The 15-residue heptaibin was also isolated from Emericellopsis sp.…”

Section: Electrospray Ionization Ms (Esi-ms) Revolutionizes the Reseamentioning

confidence: 98%

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Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing C^α‐Dialkylamino Acids?

Degenkolb

Brückner

2008

Chemistry & Biodiversity

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Fungi are generally regarded as a literally infinite resource of bioactive secondary metabolites displaying remarkable structural diversity. Research on a particular group of linear and cyclic peptide antibiotics comprehensively named peptaibiotics--as result of the abundance of the non-proteinogenic C(alpha)-dialkylated alpha-amino acids alpha-aminoisobutyric acid (Aib) and isovaline (Iva)--has been started 50 years ago. These peptides have gained constantly increasing interest because of their unique bioactivities and conformations. This review, reflecting the history of peptaibiotic research from 1958 to 2008, is focussed on introducing both the structural diversity and natural microheterogeneity of the peptaibiotics, as well as the biodiversity of their fungal producers. Recently introduced state-of-the-art methods for rapid screening and sequencing of peptaibiotics, such as peptaibiomics and intact-cell MALDI-TOF mass spectrometry, are discussed. Finally, future prospects in peptaibiotic research are presented. Owing to the ubiquity and biodiversity of the fungal producers in the biosphere, the discovery of a myriad of peptaibiotics within the next decade is predicted.

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Antiamoebins, myrocin B and the basis of antifungal antibiosis in the coprophilous fungus Stilbella erythrocephala (syn. S. fimetaria)

Cited by 38 publications

References 29 publications

Current status of cow dung as a bioresource for sustainable development

Current status of cow dung as a bioresource for sustainable development

Aib and Iva in the Biosphere: Neither Rare nor Necessarily Extraterrestrial

Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing C^α‐Dialkylamino Acids?

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Antiamoebins, myrocin B and the basis of antifungal antibiosis in the coprophilous fungus Stilbella erythrocephala (syn. S. fimetaria)

Cited by 38 publications

References 29 publications

Current status of cow dung as a bioresource for sustainable development

Current status of cow dung as a bioresource for sustainable development

Aib and Iva in the Biosphere: Neither Rare nor Necessarily Extraterrestrial

Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing Cα‐Dialkylamino Acids?

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Resources

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Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing C^α‐Dialkylamino Acids?