Antiandrogen Flutamide-Induced Restoration of miR-449 Expression Mitigates Functional Biomarkers Associated with Ovarian Cancer Risk
Xia Wang,
Ho-Hyung Woo,
Michele Wei
et al.
Abstract:BackgroundThe involvement of the androgen and androgen receptor (AR) pathway in the development of epithelial ovarian cancer is increasingly recognized. However, the specific mechanisms by which anti-androgen agents, such as flutamide, may prevent ovarian cancer and their efficacy remain unknown. We examined the effects of flutamide on the miRNA expression profile found in women at high risk (HR) for ovarian cancer.MethodsOvarian and tubal tissues, free from ovarian, tubal, peritoneal cancers, and serous tubal… Show more
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