1996
DOI: 10.1016/0014-2999(96)00105-7
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Antianginal effects of FR144420, a novel slow nitric oxide-releasing agent

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Cited by 8 publications
(8 citation statements)
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“…The inhibitory efficacy of FK409 at the same dose was greater than that of FR144420 and a significant anti-anginal effect was observed at 5 min. On the other hand, when FR144420 and FK409 were administered intraduodenally at 1.0 mg/kg, they both induced hypotension after only 5 min [40]. Thus, the anti-anginal effect of FR144420 was separated from the hypotensive effect by an interval of 180 min in contrast to the simultaneous induction of the anti-anginal and hypotensive effects of FK409 after 5min.…”
Section: ) Fr144420 and Fr146801mentioning
confidence: 90%
“…The inhibitory efficacy of FK409 at the same dose was greater than that of FR144420 and a significant anti-anginal effect was observed at 5 min. On the other hand, when FR144420 and FK409 were administered intraduodenally at 1.0 mg/kg, they both induced hypotension after only 5 min [40]. Thus, the anti-anginal effect of FR144420 was separated from the hypotensive effect by an interval of 180 min in contrast to the simultaneous induction of the anti-anginal and hypotensive effects of FK409 after 5min.…”
Section: ) Fr144420 and Fr146801mentioning
confidence: 90%
“…5) FR144420 produced significant inhibition of ST depression for 185 minutes in the coronary vasoconstriction model. 8) No such study with the cerebral vasospasm model has been performed. However, we think that intrathecal or intracisternal administration of such long-acting NO donating agents might be suitable for the treatment and prevention of SAH-induced cerebral vasospasm.…”
Section: Discussionmentioning
confidence: 99%
“…16,17) NO is involved in the regulation of the cerebral circulation, and is accepted as the most effective relaxing agent for the cerebral arterial network, and participates in the maintenance of resting cerebrovascular tone. 7,8) Depletion of NO is thought to be important in the pathogenesis of cerebral vasospasm. 9) No donors have been used to restore long-term reduced NO levels, mainly intravenous sodium nitroprusside and nitroglycerin.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, Hirasawa et al reported that FR144420 had a longer duration of antianginal action in rat angina models than FK409 and ISDN (20). In the methacholine-induced coronary vasospasm model, FR144420 suppressed the elevation of the ST segment significantly at 1 .O mg/kg even at 185 rnin after intraduodenal administration.…”
Section: Antianginal Effectsmentioning
confidence: 99%