Antiangiogenesis for Rheumatoid Arthritis

Roccaro, Aldo M.; Russo, Francesca; Cirulli, Teresa; Pietro, Guilia Di; Vacca, Angelo; Dammacco, Franco

doi:10.2174/1568010053622911

Cited by 38 publications

(30 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is characterized by infiltration of inflammatory cells and formation of new blood vessels. Angiogenesis occurs since the early stage of the disease, and supports progression of the arthritis (Roccaro et al, 2005). The results in this paper demonstrated that inflammation inhibitors may have the potential to be the angiogenesis inhibitors because the anti-inflammatory traditional botanical Tripterygium wilfordii and its terpenoids, triptolide and celastrol, also showed potent antiangiogenic activity in zebrafish embryos.…”

Section: Discussionmentioning

confidence: 67%

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

Liu

et al. 2009

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 67%

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

Liu

et al. 2009

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Elevated levels of VEGF were found in rheumatoid arthritis patients, and administration of soluble VEGFR-1 attenuated the disease process in an animal model of rheumatoid arthritis (49). Increased VEGF levels have also been reported in polycystic ovary syndrome, one of the leading causes of female infertility (50).…”

Section: Vegf Signaling and Disease-therapeutic Approachesmentioning

confidence: 95%

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

Kowanetz¹,

Ferrara²

2008

AACR Education book

177

224

View full text Add to dashboard Cite

Th e establishment of a vascular supply is one of the earliest and most important events occurring during embryonic development. Growth and maturation of a functional vascular network are complex and still incompletely understood processes involving orchestrated activation of vascular progenitors in the early stages of embryonic development followed by vasculogenesis and angiogenesis. Th ese processes require a tightly regulated activation of several growth factors and their receptors. Th e role of vascular endothelial growth factors (VEGF) and their receptors has been studied extensively due to their prominent role during blood vessel formation. Mice defi cient in various VEGF ligands or receptors show serious defects in vascular formation and maturation. Moreover, members of the VEGF family are involved in other signifi cant biological processes, including lymphangiogenesis, vascular permeability, and hematopoiesis. Importantly, VEGF is released by tumor cells and induces tumor neovascularization. It is now well established that the VEGF axis represents an important target for antitumor therapy. Aberrant VEGF signaling is also a feature of several other pathologic conditions, such as age-related macular degeneration and rheumatoid arthritis.

show abstract

Section: Vegf Signaling and Diseaseötherapeutic Approachesmentioning

confidence: 98%

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

Kowanetz¹,

Ferrara²

2006

Clinical Cancer Research

482

197

View full text Add to dashboard Cite

The establishment of a vascular supply is one of the earliest and most important events occurring during embryonic development. Growth and maturation of a functional vascular network are complex and still incompletely understood processes involving orchestrated activation of vascular progenitors in the early stages of embryonic development followed by vasculogenesis and angiogenesis. These processes require a tightly regulated activation of several growth factors and their receptors. The role of vascular endothelial growth factors (VEGF) and their receptors has been studied extensively due to their prominent role during blood vessel formation. Mice deficient in various VEGF ligands or receptors show serious defects in vascular formation and maturation. Moreover, members of the VEGF family are involved in other significant biological processes, including lymphangiogenesis, vascular permeability, and hematopoiesis. Importantly, VEGF is released by tumor cells and induces tumor neovascularization. It is now well established that the VEGF axis represents an important target for antitumor therapy. Aberrant VEGF signaling is also a feature of several other pathologic conditions, such as age-related macular degeneration and rheumatoid arthritis.

show abstract

Antiangiogenesis for Rheumatoid Arthritis

Cited by 38 publications

References 37 publications

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

Contact Info

Product

Resources

About